The Journal of Practical Medicine >

2026 , Vol. 42 >Issue 11: 1949 - 1958

DOI: https://doi.org/10.3969/j.issn.1006-5725.2026.11.008

Chronic Disease Control

Research advances in functionalized exosomes for orthopedic disease treatment

  • Yuele MA ,
  • Yan WANG ,
  • Hongwei CUI ,
  • Hui ZHANG ,
  • Yujing CHEN ,
  • Benchao DONG ,
  • Peichuan YANG ,
  • Jianxiong MA
Expand
  • 1.Tianjin Hospital Orthopedic Research Institute，Tianjin 300050，Tianjin，China
    2.Tianjin Medical University Orthopaedic Clinical College，Tianjin 300070，Tianjin，China

Received date: 2026-01-13

  Online published: 2026-06-15

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Abstract

With the continuous development of society and the progress of medical science， the treatments for orthopedic diseases are gradually evolving towards precision medicine. As natural nanovesicles， exosomes possess outstanding biocompatibility and targeting abilities. Through functional modifications including genetic engineering， drug loading， and surface modification， exosomes can precisely facilitate bone regeneration， regulate bone metabolism， and reshape the immune micro-environment. They show remarkable potential in the treatment of orthopedic disorders such as fractures， osteoarthritis， and osteoporosis. Nevertheless， there are still challenges in standardized preparation， efficacy evaluation， safety assessment， and clinical translation. This article systematically reviews the most recent advances in functionalized exosomes for the treatment of orthopedic diseases， encompassing their sources， preparation methods， functionalization strategies， and mechanisms of action. It summarizes the application progress of functionalized exosomes in orthopedic therapy， discusses the current technical challenges and future development directions， and is of great significance for the translation of functionalized exosomes from laboratory research to clinical application in orthopedics.

Key words： fracture; osteoarthritis; osteoporosis; exosomes; miRNA

Cite this article

Yuele MA , Yan WANG , Hongwei CUI , Hui ZHANG , Yujing CHEN , Benchao DONG , Peichuan YANG , Jianxiong MA . Research advances in functionalized exosomes for orthopedic disease treatment[J]. The Journal of Practical Medicine, 2026 , 42(11) : 1949 -1958 . DOI: 10.3969/j.issn.1006-5725.2026.11.008

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