The Journal of Practical Medicine >

2026 , Vol. 42 >Issue 9: 1586 - 1591

DOI: https://doi.org/10.3969/j.issn.1006-5725.2026.09.013

Chronic Disease Control

Research progress of palmitoylation promoting vascular aging-related cardiovascular diseases

  • Shiqin WU ,
  • Jian YANG ,
  • Cuiyuan HUANG ,
  • Li LIU ,
  • Wenqiang LI ,
  • Wei WANG ,
  • Jing ZHANG
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  • 1.Department of Cardiology，the First College of Clinical Medical Science，China Three Gorges University & Yichang Central People's Hospital，Yichang 443002，Hubei，Chin
    2Central Laboratory，the First College of Clinical Medical Science，China Three Gorges University & Yichang Central People's Hospital，Yichang 443002，Hubei，Chin
    3Hubei Key Laboratory of Ischemic Cardiovascular Disease，Yichang 443002，Hubei，Chin
    4Hubei Provincial Clinical Research Center for Ischemic Cardiovascular Disease，Yichang 443002，Hubei，China

Received date: 2025-08-21

  Online published: 2026-04-29

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Abstract

Vascular aging， characterized by increased arterial stiffness， vascular wall remodeling， and endothelial dysfunction， is a crucial factor in the occurrence and development of cardiovascular diseases， such as hypertension， atherosclerosis， and cardiac insufficiency. Palmitoylation， a post-translational modification of proteins that involves the addition of palmitic acid， plays a pivotal role in vascular aging. Protein palmitoylation exerts a regulatory effect on the process of vascular aging by modulating the membrane localization， stability， and signal transduction of key proteins in vascular cells， and by participating in oxidative stress， inflammation amplification， impaired endothelial barrier function， abnormal transformation of smooth muscle phenotype， autophagy， and protein homeostasis imbalance. These effects are interwoven and influence the occurrence and development of various cardiovascular-related disease events. Protein palmitoylation is of great significance in vascular aging and offers an important strategy for the prevention and treatment of related cardiovascular events.

Key words： cardiovascular disease; vascular aging; related cardiovascular diseases; palmitoylation modification; DHHC palmitoyltransferase; protein post-translational modification

Cite this article

Shiqin WU , Jian YANG , Cuiyuan HUANG , Li LIU , Wenqiang LI , Wei WANG , Jing ZHANG . Research progress of palmitoylation promoting vascular aging-related cardiovascular diseases[J]. The Journal of Practical Medicine, 2026 , 42(9) : 1586 -1591 . DOI: 10.3969/j.issn.1006-5725.2026.09.013

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