The Journal of Practical Medicine >

2026 , Vol. 42 >Issue 8: 1450 - 1455

DOI: https://doi.org/10.3969/j.issn.1006-5725.2026.08.020

Treatise: Clinical Practice

Predictive value of embryo dynamics parameters based on embryo time-lapse imaging technique on embryo implantation potential in patients with IVF-ET assisted pregnancy

  • Xiaoxin HU ,
  • Yanchen GUO ,
  • Xiaolin LIU ,
  • Ying WANG ,
  • Hong YAN
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  • 1.Department of Reproductive Medicine，Nanyang First People's Hospital，Nanyang 473000，Henan，China
    2.Department of Reproductive Medicine，Jiaozuo Maternal and Child Health Hospital，Jiaozuo 454100，Henan，China

Received date: 2025-11-11

  Online published: 2026-04-28

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Abstract

Objective To evaluate the predictive value of embryo dynamics parameters during embryo time-lapse imaging technique on embryo implantation potential in patients receiving in vitro fertilization-embryo transfer （IVF-ET） assisted pregnancy. Methods A total of 292 patients who underwent IVF-ET assisted pregnancy at Nanyang First People's Hospital between June 2022 and June 2024 were selected as study subjects. After 28 days of transplantation， the patients were divided into 103 cases in implantation group and 189 cases in non-implantation group based on the embryo implantation status detected by B-ultrasound. The basic data and embryo dynamics parameters of the patients in each group were compared. Multivariate logistic regression analysis was conducted to identify high-risk factors for embryo non-implantation in patients with IVF-ET assisted pregnancy. Subsequently， the predictive value of these high-risk factors on embryo implantation potential was evaluated by using receiver operating characteristic （ROC） curve. Results Compared with implantation group， the embryo dynamics parameters in non-implantation group were higher， including the time of pronuclear breakdown to 2-cell stage （t2）， time of pronuclear breakdown to 3-cell stage （t3）， time of pronuclear breakdown to 4-cell stage （t4）， time of 2-cell division to 3-cell stage （cc2）， time of 3-cell division to 4-cell stage （s2）， and time of 4-cell division to 5-cell stage （cc3） （P < 0.05）. t2 （OR = 4.293）， t3 （OR = 0.507）， t4 （OR = 5.534） and s2 （OR = 3.755） were independent risk factors for embryo non-implantation in patients with IVF-ET assisted pregnancy （P < 0.05）. t2， t3， t4 and s2 had high predictive efficiency on embryo implantation failure in patients with IVF-ET assisted pregnancy， and their areas under the curves （AUCs） were 0.767， 0.744， 0.720 and 0.878 respectively （P < 0.05）， and the efficiency of s2 in predicting embryo non-implantation in patients with IVF-ET assisted pregnancy was higher than that of t2， t3 or t4 （Z = 3.044， 3.563， 4.413， P < 0.05）. Conclusions The levels of embryo dynamics parameters t2， t3， t4 and s2 are closely related to the embryo implantation in patients with IVF-ET assisted pregnancy. The use of embryo time-lapse imaging technique can assist medical staff in predicting the embryo implantation potential in patients with IVF-ET assisted pregnancy.

Key words： embryo time-lapse imaging technique; embryo dynamics; in vitro fertilization-embryo transfer; embryo implantation

Cite this article

Xiaoxin HU , Yanchen GUO , Xiaolin LIU , Ying WANG , Hong YAN . Predictive value of embryo dynamics parameters based on embryo time-lapse imaging technique on embryo implantation potential in patients with IVF-ET assisted pregnancy[J]. The Journal of Practical Medicine, 2026 , 42(8) : 1450 -1455 . DOI: 10.3969/j.issn.1006-5725.2026.08.020

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