The Journal of Practical Medicine >

2026 , Vol. 42 >Issue 8: 1444 - 1449

DOI: https://doi.org/10.3969/j.issn.1006-5725.2026.08.019

Treatise: Clinical Practice

Prediction of pregnancy outcomes by PAPP-A combined with TPO-Ab in patients with subclinical hypothyroidism complicated with gestational hypertension

  • Xueqin ZHENG ,
  • Ying HU
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  • 1.Department of Obstetrics and Gynecology，Chaohu Hospital Affiliated to Anhui Medical University，Chaohu 238000，Anhui，Chin
    2Department of Obstetrics，Chaohu Hospital Affiliated to Anhui Medical University，Chaohu 238000，Anhui，China

Received date: 2025-11-25

  Online published: 2026-04-28

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Abstract

Objective To explore the predictive value of pregnancy-associated plasma protein A （PAPP-A） combined with thyroid peroxidase antibody （TPO-Ab） for pregnancy outcomes in patients with subclinical hypothyroidism complicated with gestational hypertension. Methods A total of 186 pregnant women with subclinical hypothyroidism admitted to the hospital from January 2020 to January 2025 were selected. They were divided into the subclinical hypothyroidism group （n = 87） and the subclinical hypothyroidism combined with gestational hypertension group （n = 99） based on the presence of gestational hypertension. Meanwhile， 102 normal pregnant women during the same period were enrolled as the control group. Basic data of all pregnant women were collected， and their serum levels of PAPP-A and TPO-Ab were detected. The occurrence of adverse pregnancy outcomes such as abortion， preterm birth， and postpartum hemorrhage in the subclinical hypothyroidism combined with gestational hypertension group was followed up and recorded. Logistic regression analysis was used to screen the risk factors for adverse pregnancy outcomes， and ROC curves were employed to evaluate the predictive value of serum PAPP-A and TPO-Ab levels for pregnancy outcomes. Results The serum PAPP-A level in the subclinical hypothyroidism combined with gestational hypertension group was lower than that in the subclinical hypothyroidism group and the control group， while the TPO-Ab level was higher， with statistically significant differences （P < 0.05）. Follow-up results showed that 46.46% （46/99） of the 99 pregnant women in the subclinical hypothyroidism combined with gestational hypertension group had adverse outcomes. Multivariate analysis indicated that elevated TPO-Ab and decreased PAPP-A were risk factors for adverse pregnancy outcomes （P < 0.05）. ROC curve analysis revealed that the combination of PAPP-A and TPO-Ab had high accuracy in evaluating the pregnancy outcomes of the patients. Conclusion Decreased PAPP-A and elevated TPO-Ab are risk factors for adverse pregnancy outcomes in patients with subclinical hypothyroidism complicated with gestational hypertension， and their combination has high predictive value for the pregnancy outcomes of such patients.

Key words： subclinical hypothyroidism in pregnancy; gestational hypertension; pregnancy-associated plasma protein A; thyroid peroxidase antibody; pregnancy outcome

Cite this article

Xueqin ZHENG , Ying HU . Prediction of pregnancy outcomes by PAPP-A combined with TPO-Ab in patients with subclinical hypothyroidism complicated with gestational hypertension[J]. The Journal of Practical Medicine, 2026 , 42(8) : 1444 -1449 . DOI: 10.3969/j.issn.1006-5725.2026.08.019

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