The Journal of Practical Medicine >

2026 , Vol. 42 >Issue 5: 785 - 791

DOI: https://doi.org/10.3969/j.issn.1006-5725.2026.05.008

Chronic Disease Control

Study on the relationship between serum Metrnl levels and pregnancy outcomes in patients with hypertriglyceridemia in late pregnancy

  • Yiming HOU ,
  • Huafang WEI ,
  • Jiayang TANG ,
  • Ziyang WANG ,
  • Ying CHEN ,
  • Ling YUE
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  • 1.Wuhan University of Science and Technology School of Medicine，Wuhan 430065，Hubei，China
    2.Department of Endocrinology，General Hospital of Central Theater Command，Wuhan 430070，Hubei，China
    3.Department of Obstetrics and Gynecology，General Hospital of Central Theater Command，Wuhan 430070，Hubei，China

Received date: 2025-11-14

  Online published: 2026-03-09

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Abstract

Objective To investigate the factors associated with adverse pregnancy outcomes （APO） and the changes in serum Meteorin-like protein （Metrnl） levels in pregnant women with hypertriglyceridemia （HTG） during late pregnancy. Methods From October 2023 to March 2025， 260 women in late pregnancy were recruited and then divided into an HTG group （n = 113） and a non-HTG group （n = 147）. General characteristics， serum Metrnl levels， clinical indicators， and the incidence of APO were compared between the two groups. Subsequently， risk factors for APO were further analyzed. Results The HTG group exhibited significantly higher incidences of APO， adverse maternal outcomes， and gestational diabetes mellitus （GDM） when compared to the non-HTG group （P < 0.05）. Serum Metrnl and HDL-C levels were notably lower in the HTG group （P < 0.05）， whereas TG， FPG， UA， TyG， TYG-BMI， and UA-S/D were significantly higher （P < 0.05）. TG was recognized as an independent risk factor for APO （OR = 1.426）； Low serum Metrnl levels were independent risk factors for APO， adverse maternal outcomes， and GDM among all pregnant women （OR = 0.997； 0.998； 0.997）， as well as specifically in the HTG group （OR = 0.994； 0.995； 0.993）. The area under the curve （AUC） for predicting APO in the HTG group using serum Metrnl levels was 0.632 （P < 0.05）； The AUC for predicting APO in the HTG group using the combination with pregnancy risk assessment was 0.758 （P < 0.05）. Conclusions Patients with HTG in late pregnancy are at a higher risk of experiencing APO， especially adverse maternal outcomes and GDM. Reduced serum Metrnl levels serve as an independent risk factor for APO， adverse maternal outcomes， and GDM in these pregnant women. The combination of serum Metrnl levels with pregnancy risk assessment demonstrates predictive value for APO in patients with HTG.

Key words： triglyceride; Metrnl; adverse pregnancy outcomes; gestational diabetes mellitus; logistic regression

Cite this article

Yiming HOU , Huafang WEI , Jiayang TANG , Ziyang WANG , Ying CHEN , Ling YUE . Study on the relationship between serum Metrnl levels and pregnancy outcomes in patients with hypertriglyceridemia in late pregnancy[J]. The Journal of Practical Medicine, 2026 , 42(5) : 785 -791 . DOI: 10.3969/j.issn.1006-5725.2026.05.008

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