The Journal of Practical Medicine >

2026 , Vol. 42 >Issue 1: 152 - 156

DOI: https://doi.org/10.3969/j.issn.1006-5725.2026.01.020

Treatise: Mechanism and Practice

Predictive value of yolk sac size morphology and inner diameter changes in early pregnancy on early abortion

  • Jingrui WEI ,
  • Qiaofang LIU ,
  • Youyun LI ,
  • Shan WANG ,
  • Shuai XU
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  • 1.Department of Reproductive Medicine，Xinxiang Central Hospital，Xinxiang 453000，Henan，Chin
    a2Department of Obstetrics，Xinxiang Central Hospital，Xinxiang 453000，Henan，China

Received date: 2025-10-13

  Online published: 2026-01-14

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Abstract

Objective To analyze the predictive value of yolk sac size morphology and inner diameter changes in early pregnancy on early abortion. Methods A total of 120 pregnant women with early pregnancy admitted to the hospital from January 2023 to December 2024 were selected as research subjects （118 cases were finally included and 2 cases were lost to follow-up）. According to the pregnancy outcomes， they were divided into normal pregnancy group （n = 82） and early abortion group （n = 36）. Baseline data and yolk sac parameters were compared between the two groups. Multivariate Logistic regression analysis was used to analyze the risk factors affecting early abortion， and ROC curve was used to evaluate the predictive value of yolk sac size morphology and inner diameter changes in early pregnancy on early abortion. Results The proportion of age ≥ 35 years old in early abortion group was significantly higher than that in the normal pregnancy group （P < 0.05）. The yolk sac diameter of each gestational week in early abortion group was significantly larger than that in normal pregnancy group （P < 0.05）. The proportion of yolk sac deletion， proportion of abnormal yolk sac diameter and proportion of abnormal yolk sac morphology were significantly higher in early abortion group than those in normal pregnancy group （P < 0.05）. Multivariate Logistic regression analysis showed that age ≥ 35 years old （OR = 1.664， 95%CI： 1.272 ~ 2.176）， yolk sac deletion （OR = 23.927， 95% CI： 9.561 ~ 59.876）， abnormal yolk sac diameter （OR = 30.114， 95%CI： 13.092 ~ 69.269） and abnormal yolk sac morphology （OR = 16.844， 95% CI： 6.359 ~ 44.617） were risk factors for early abortion. ROC curve analysis showed that the abnormal yolk sac morphology had the highest value on predicting early abortion （AUC = 0.862）， followed by abnormal yolk sac diameter （AUC = 0.669） and yolk sac deletion （AUC = 0.611）. Conclusion The abnormal morphology of yolk sac in early pregnancy can be used as an important indicator to predict early abortion and provide scientific basis for early intervention.

Key words： early abortion; yolk sac; morphology; early pregnancy; predictive value

Cite this article

Jingrui WEI , Qiaofang LIU , Youyun LI , Shan WANG , Shuai XU . Predictive value of yolk sac size morphology and inner diameter changes in early pregnancy on early abortion[J]. The Journal of Practical Medicine, 2026 , 42(1) : 152 -156 . DOI: 10.3969/j.issn.1006-5725.2026.01.020

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