The Journal of Practical Medicine >

2021 , Vol. 37 >Issue 5: 691 - 695

DOI: https://doi.org/10.3969/j.issn.1006⁃5725.2021.05.026

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Effect of heavy metals exposure on DNA methylation and its association with congenital heart disease：a literature review

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  • Guangdong General Hospital（Guangdong Academy of Medical Sciences），Guangzhou 510080，China；*Shantou University of Medical Collage，Shantou 515063， China

Online published: 2021-03-10

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Abstract

Congenital heart disease（CHD），the most common congenital malformation，results mainly from mutual reactions of hereditary and environmental factors. Exposure to heavy metals as an environmental factor has been proved to induce DNA methylation，which is one of the epigenetic mechanisms regulating gene expres⁃ sion. The alterations in epigenetic level may be critical for the development of CHD. By literature review，the corre⁃ lations of exposure to heavy metals such as lead（Pb），cadmium（Cd），arsenic（As），nickel（Ni），mercury （Hg）with DNA methylation as well as CHD are comprehensively investigated，for further researches.

Key words：

; epigenetic; heavy metals; congenital heart disease

Cite this article

QIU Yiling, CHEN Le, JIANG Yanping. .

Effect of heavy metals exposure on DNA methylation and its association with congenital heart disease：a literature review

[J]. The Journal of Practical Medicine, 2021 , 37(5) : 691 -695 . DOI: 10.3969/j.issn.1006⁃5725.2021.05.026

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