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Exploration and challenges of neoadjuvant therapy in the management of resectable hepatocellular carcinoma
Received date: 2025-09-28
Online published: 2025-12-18
Neoadjuvant therapy for hepatocellular carcinoma is the frontier and hot topic in the current field of liver cancer research. The fundamental purpose is to reduce the risk of postoperative recurrence through standardized preoperative treatment methods. From the attempts of Transcatheter Arterial Chemoembolization monotherapy for neoadjuvant therapy for hepatocellular carcinoma to systematic treatment represented by “targeted combined with immunotherapy”， the latter has become the most promising neoadjuvant strategy due to its high objective response rate and potential to induce pathological complete remission. However， the field still faces challenges such as lack of evidence of overall survival benefit in Phase Ⅲ randomized controlled trials， treatment-related adverse reactions that may lead to delay in surgery， optimal population screening， and timing of surgery. This article aims to briefly discuss the current research status of the application of neoadjuvant therapy in resectable hepatocellular carcinoma， explore relevant diagnosis and treatment concepts， and further understand neoadjuvant therapy.
Xin LIU , Yutao HE , Fangming TIAN , Haocheng TANG , Zhitian SHI , Lin. WANG . Exploration and challenges of neoadjuvant therapy in the management of resectable hepatocellular carcinoma[J]. The Journal of Practical Medicine, 2025 , 41(23) : 3780 -3785 . DOI: 10.3969/j.issn.1006-5725.2025.23.022
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