Feature Reports:colon cancer

A randomized controlled trial on the efficacy of compound polyethylene glycol electrolyte powder combined with linaclotide for bowel preparation in elderly constipated patients before colonoscopy

  • Jianjun ZHANG ,
  • Haipeng WANG ,
  • Guangfeng DONG ,
  • Ming CHEN ,
  • Jinqi LIU ,
  • Hao ZHANG ,
  • Mingjuan SUN ,
  • Meng LU ,
  • Huizhuan ZHAI ,
  • Xingguang HUANG ,
  • Zengjun LI ,
  • Dongyang. WANG
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  • *.Department of Oncology,Shandong First Medical University Affiliated Tumor Hospital,Jinan 250117,Shandong,China

Received date: 2025-06-14

  Online published: 2025-10-10

Abstract

Objective To evaluate the efficacy and safety of polyethylene glycol electrolyte powder (PEG) combined with linaclotide (Lin) for bowel preparation in elderly constipated patients before colonoscopy. Methods In this prospective, randomized controlled trial, 90 elderly patients with constipation undergoing colonoscopy were recruited at our hospital from June 2022 to December 2023. Participants were randomly assigned to three groups (n = 30 each): PEG-3L alone, PEG-3L + Lin, and PEG-2L + Lin. Primary outcome was Boston Bowel Preparation Scale (BBPS) score and secondary outcomes included adverse event rates, colonoscopy completion rate, withdrawal time, and polyp detection rate. Statistical analysis was performed using independent t-tests and chi-square tests. Results The PEG-3L + Lin group achieved significantly higher BBPS scores than both PEG-3L alone and PEG-2L + Lin groups did (both P < 0.001). The PEG-2L + Lin group also outperformed the PEG-3L alone group in cleansing efficacy (90.0% vs. 76.7%, P = 0.008). The PEG-2L + Lin group demonstrated the best tolerability and lowest adverse event rate, the PEG-3L group had the longest withdrawal time (P < 0.05), but the three groups showed no significant difference in polyp detection rates. Conclusion PEG combined with linaclotide significantly improves bowel cleansing in elderly constipated patients. PEG-2L + Lin regimen provides optimal balance between efficacy, safety, and tolerability, making it a preferable choice for this population.

Cite this article

Jianjun ZHANG , Haipeng WANG , Guangfeng DONG , Ming CHEN , Jinqi LIU , Hao ZHANG , Mingjuan SUN , Meng LU , Huizhuan ZHAI , Xingguang HUANG , Zengjun LI , Dongyang. WANG . A randomized controlled trial on the efficacy of compound polyethylene glycol electrolyte powder combined with linaclotide for bowel preparation in elderly constipated patients before colonoscopy[J]. The Journal of Practical Medicine, 2025 , 41(19) : 2967 -2971 . DOI: 10.3969/j.issn.1006-5725.2025.19.002

References

[1] 中国医师协会内镜医师分会消化内镜专业委员会,中国抗癌协会肿瘤内镜学专业委员会. 中国消化内镜诊疗相关肠道准备指南(2019,上海)[J].中华消化内镜杂志,2019,36(7):457-469.
[2] KIM S Y, KIM H S, PARK H J. Adverse events related to colonoscopy: Global trends and future challenges[J]. World J Gastroenterol, 2019,25(2):190-204. doi:10.3748/wjg.v25.i2.190
[3] 张文娟,王朝霞. 4种不同肠道准备方法对无痛结肠镜检查老年患者机体的影响 [J]. 中国老年学杂志,2016,36(13): 3265-3266.
[4] 白爱莲,侯丽英,张惠玲,等. 慢性便秘患者结肠镜检查前肠道准备不合格的影响因素及护理对策分析[J]. 中华现代护理杂志,2022,28(1):86-90.
[5] BERAN A, ABOURSHEID T, ALI A H, et al. Risk Factors for Inadequate Bowel Preparation in Colonoscopy: A Comprehensive Systematic Review and Meta-Analysis[J]. Am J Gastroenterol, 2024,119(12):2389-2397. doi:10.14309/ajg.0000000000003073
[6] 徐浩馨,朱鹤,徐红. 结肠镜检查前肠道准备中利那洛肽的应用现状[J]. 中华消化内镜杂志,2024,41(10):836-840.
[7] 李夏西,刘清华,蒲瑶,等. 利那洛肽联合复方聚乙二醇电解质散用于结肠镜肠道准备的临床研究[J]. 中华消化内镜杂志,2023,40(4):288-292.
[8] 杨少鹏,李志婷,徐力东,等. 影响肠道准备质量的患者相关因素 [J]. 中国老年学杂志,2018,38 (22): 5469-5471.
[9] SHAHINI E, SINAGRA E, VITELLO A, et al. Factors affecting the quality of bowel preparation for colonoscopy in hard-to-prepare patients: Evidence from the literature[J]. World J Gastroenterol, 2023,29(11):1685-1707. doi:10.3748/wjg.v29.i11.1685
[10] LAI E J, CALDERWOOD A H, DOROS G, et al. The Boston bowel preparation scale: A valid and reliable instrument for colonoscopy-oriented research[J]. Gastrointest Endosc, 2009,69(3 Pt 2):620-625. doi:10.1016/j.gie.2008.05.057
[11] 李鹏,王拥军,陈光勇,等. 中国早期结直肠癌及癌前病变筛查与诊治共识[J]. 中国实用内科杂志,2015,35(3):211-227.
[12] DOYKOV D, ANDONOV V. Risk factors and incidence of poor bowel preparation in elderly patients: Prospective study[J]. Folia Med (Plovdiv), 2019, 61(3): 370-376. doi:10.3897/folmed.61.e39409
[13] 中华医学会消化病学分会胃肠动力学组, 中华医学会消化病学分会功能性胃肠病协作组. 中国慢性便秘专家共识意见(2019,广州)[J]. 中华消化杂志,2019,39(9):577-598.
[14] 宋杰,曲桂玉,林云英,等. 老年人结肠镜检查肠道准备不良影响因素的Meta分析 [J]. 中国老年学杂志,2020,40(3): 548-552.
[15] WANG S, SUN H. Application and advantages of polyethylene glycol in bowel preparation[J]. Digestive Medicine,2020,36(5):230-235.
[16] KANG X, ZHAO L, ZHU Z, et al. Same-day single dose of 2 liter polyethylene glycol is not inferior to the standard bowel preparation regimen in low-risk patients: A randomized, controlled trial[J]. Am J Gastroenterol, 2018, 113(4):601-610. doi:10.1038/ajg.2018.25
[17] YANG Y, FANG J, GUO X, et al. Linaclotide in irritable bowel syndrome with constipation: A phase 3 randomized trial in China and other regions[J]. J Gastroenterol Hepatol, 2018,33(5):980-989. doi:10.1111/jgh.14086
[18] 王同昌,汪嵘,潘鹏,等. 利那洛肽联合复方聚乙二醇在结肠镜肠道准备中应用的初步研究[J]. 中华消化内镜杂志,2023,40(11):915-920.
[19] 谈涛,顿珊珊,熊利芬,等. 利那洛肽联合聚乙二醇方案对肠道准备效果的随机对照研究[J]. 中华消化杂志,2022,42(10):681-685.
[20] SUN P, WU X, ZHANG Q. Safety profile of polyethylene glycol and linaclotide for bowel cleansing in elderly patients with multiple comorbidities[J]. J Gastrointest Surg,2022, 26(5):1028-1035.
[21] ADLER A, WEGSCHEIDER K, LIEBERMAN D, et al. Factors determining the quality of screening colonoscopy: A prospective study on adenoma detection rates, from 12,134 examinations (Berlin colonoscopy project 3, BECOP-3)[J]. Gut, 2013,62(2):236-241. doi:10.1136/gutjnl-2011-300167
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