The Journal of Practical Medicine >

2025 , Vol. 41 >Issue 16: 2561 - 2567

DOI: https://doi.org/10.3969/j.issn.1006-5725.2025.16.018

Clinical Research

Prognostic value of serum thrombospondin‑1 combined with alberta stroke program early CT score in patients with acute large‑vessel occlusive cerebral infarction

  • Hao JIANG ,
  • Kaili CHENG ,
  • Liu. CHEN
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  • Department of Neurology，Daqing People's Hospital （Harbin Medical University Affiliated Fifth Hospital），Daqing 163000，Heilongjiang，China

Received date: 2025-06-09

  Online published: 2025-08-28

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Abstract

Objective To investigate the prognostic value of serum thrombospondin-1 （THBS-1） combined with Alberta Stroke Program Early CT Score （ASPECTS） in patients with acute cerebral infarction with large vessel occlusion （ACI-LVO）. Methods A total of 198 ACI-LVO patients admitted to the hospital from January 2022 to October 2024 were prospectively enrolled （ACI-LVO group）. Patients were categorized into mild， moderate， and severe subgroups based on National Institutes of Health Stroke Scale （NIHSS） scores， and into good or poor prognosis groups based on 90-day outcomes. Serum THBS-1 levels were measured using ELISA， and ASPECTS scores were calculated. Spearman correlation analysis was used to assess the relationship between THBS-1， ASPECTS， and NIHSS scores. Prognostic factors and predictive values of THBS-1 and ASPECTS were also analyzed. Results Among the 198 patients， 58 had mild， 67 had moderate， and 73 had severe ACI-LVO. Serum THBS-1 levels increased， and ASPECTS scores decreased progressively with worsening disease severity （P < 0.05）. NIHSS scores were positively correlated with serum THBS-1 and negatively correlated with ASPECTS scores （P < 0.05）. The 90-day poor outcome rate was 37.37%（74/198）. Independent risk factors for poor prognosis included older age， modified thrombolysis in cerebral infarction score of 0 ~ 2a， higher NIHSS score， larger infarct volume， hemorrhagic transformation， and elevated THBS-1. A higher ASPECTS score was an independent protective factor （P < 0.05）. The area under the curve （AUC） for predicting prognosis was 0.794 for THBS-1， 0.831 for ASPECTS， and 0.903 for their combination， with the combined model showing superior predictive value （P < 0.05）. Conclusions Elevated serum THBS-1 and decreased ASPECTS scores are associated with increased disease severity and poorer prognosis in ACI-LVO patients. The combination of serum THBS-1 and ASPECTS score provides high predictive value for assessing prognosis in ACI-LVO patients.

Key words： acute cerebral infarction with large vessel occlusion; tThrombospondin-1; alberta stroke program early CT score; prognosis

Cite this article

Hao JIANG , Kaili CHENG , Liu. CHEN . Prognostic value of serum thrombospondin‑1 combined with alberta stroke program early CT score in patients with acute large‑vessel occlusive cerebral infarction[J]. The Journal of Practical Medicine, 2025 , 41(16) : 2561 -2567 . DOI: 10.3969/j.issn.1006-5725.2025.16.018

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