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Value of serum TFPI-1 combined with NF-κB in prognostic analysis of severe traumatic brain injury
Received date: 2025-03-18
Online published: 2025-08-28
Objective To evaluate the prognostic value of serum tissue factor pathway inhibitor-1 （TFPI-1） combined with nuclear factor-κB （NF-κB） in severe traumatic brain injury （STBI）. Methods The medical records of 127 patients with STBI admitted to the hospital from July 2022 to August 2024 were retrospectively analyzed and followed up for 6 months. They were divided into poor prognosis group （n = 53） and good prognosis group （n = 74） according to the prognosis of STBI patients.The serum NF-κB level， clinical data and serum TFPI-1 level of the two groups were compared. The factors affecting the adverse prognosis of STBI patients was screened， and the value of serum NF-κB and serum TFPI-1 in predicting the adverse prognosis of STBI patients were analyzed. Results The serum NF-κB level in the poor prognosis group was higher than good prognosis group， and the serum TFPI-1 level was lower than good prognosis group（P < 0.05）. The proportion of patients aged > 60 years old was higher than good prognosis group （P < 0.05）. Serum TFPI-1 level （OR = 0.328， 95%CI： 0.156 ~ 0.689） was a protective factor for poor prognosis in STBI patients （P < 0.05）， serum NF-κB level （OR = 3.773， 95%CI： 1.797~7.924） and age > 60 years （OR = 3.543， 95%CI： 1.687 ~ 7.441） were independent risk factors for poor prognosis in STBI patients （P<0.05）. The area under the curve （AUC） of serum TFPI-1 and NF-κB levels and their combined prediction of poor prognosis in STBI patients were 0.784， 0.847 and 0.931， respectively （P < 0.05）， and the AUC value of the combined TFPI-1 and NF-κB levels was higher （P < 0.05）. Conclusion Serum NF-κB combined with serum TFPI-1 has higher prognostic value in STBI patients.
Biao LENG , Dequan HONG , Ming TAN , Ming TIAN , Shanliang XIE , Yaoran. TU . Value of serum TFPI-1 combined with NF-κB in prognostic analysis of severe traumatic brain injury[J]. The Journal of Practical Medicine, 2025 , 41(16) : 2455 -2460 . DOI: 10.3969/j.issn.1006-5725.2025.16.003
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