The Journal of Practical Medicine >
Research progress on mitochondrial homeostasis in vascular cognitive impairment
Received date: 2025-01-06
Online published: 2025-07-02
Vascular cognitive impairment （VCI） is a type of cognitive dysfunction caused by cerebrovascular lesions， and its pathological mechanism includes mitochondrial damage. Therefore， maintaining mitochondrial homeostasis is crucial in the occurrence and progression of VCI. Mitochondrial homeostasis involves multiple levels， including biogenesis， autophagy， ion balance， protein quality control， membrane dynamics， and interactions with other organelles. This study outlines the regulatory mechanisms of mitochondrial homeostasis dysregulation at both the micro and macro levels， delves into the key role of mitochondrial homeostasis in VCI， analyzes potential therapeutic directions， and provides new scientific evidence and perspectives for the early diagnosis and treatment of VCI.
Linghui DAI , Weifeng LI . Research progress on mitochondrial homeostasis in vascular cognitive impairment[J]. The Journal of Practical Medicine, 2025 , 41(12) : 1936 -1944 . DOI: 10.3969/j.issn.1006-5725.2025.12.024
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