Objective To assess the clinical effectiveness of Poly（p-dioxanone）（PPDO） bidirectional sawtooth inverted V-shaped wiring and straight wiring in ameliorating nasolabial fold wrinkles within the context of facial rejuvenation. Methods Between March 2023 and January 2024， 60 patients presenting with nasolabial fold wrinkles who underwent PPDO subcutaneous implantation and lifting in the Department of Plastic Surgery at the First Affiliated Hospital of Bengbu Medical University were randomly allocated into an observation group and a control group. At 4 weeks， 12 weeks， and 24 weeks post-surgery， the clinical efficacy was statistically analyzed. The incidence of complications was documented to evaluate the safety of the procedure， and a satisfaction survey was carried out. Results In each time period， the Wrinkle Severity Rating Scale （WSRS） scores of both groups decreased significantly when compared to those prior to the operation （P < 0.05）. At each corresponding time point after surgery， there was a statistically significant difference in the WSRS scores between the two groups in the observation group （P < 0.05）. In both groups， the WSRS score was the lowest at 12 weeks post-surgery， and the score at 24 weeks post-surgery was significantly higher than that at 12 weeks post-surgery （P < 0.05）. The overall effective rate of facial improvement in the observation group was 93.33%， which was significantly higher than that in the control group （73.33%）. The difference was statistically significant （χ² = 4.320， P < 0.05）. No obvious complications occurred in either group. The satisfaction rate in the observation group was 4.067 ± 0.828， which was significantly higher than that in the control group （3.400 ± 0.932）. The difference was statistically significant （t = 2.929， P < 0.05）. Conclusions Both the PPDO two-way sawtooth line inverted V-shaped wiring method and the straight wiring method can effectively improve nasolabial fold wrinkles. Compared with the straight wiring method， the inverted V wiring method demonstrates a more pronounced improvement effect， higher subject satisfaction， and fewer consumables. The optimal results were achieved at 12 weeks after surgery for both wiring methods. Moreover， neither surgical procedure was associated with significant complications.