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Research progress on the engineering construction of biomimetic auricle reconstruction prosthesis
Received date: 2025-02-27
Online published: 2025-07-02
Biomaterials provide a reliable and safe treatment for the repair of ear defects， especially microtia. With the continuous promotion of interdisciplinary research， the types and properties of materials used in auricle reconstruction have been greatly expanded and improved. In this paper， the latest research progress of polymer materials and tissue engineering scaffolds in the field of auricle reconstruction was reviewed， and the physical and chemical properties and clinical application effects of these scaffolds in vitro and in vivo were discussed. However， despite significant progress in ear stent research， there are still some challenges and limitations in the application of current polymer materials， such as the hydrophobicity of high-density polyethylene and the uncontrolled differentiation of stem cells in tissue engineering. Therefore， this paper discusses the research and clinical application of new modified materials， especially emphasizing the importance of surface modification technology and innovative synthesis strategies， so that the properties of modified materials are infinitely close to the characteristics of human ear cartilage. In addition， this paper also summarizes the control methods of stem cell differentiation in ear cartilage tissue engineering. The application performance and biocompatibility of different ear scaffolds were reviewed in order to provide guidance for auricle reconstruction.
Key words： auricle reconstruction; ear support; tissue engineering; biomaterial
Yunyun WANG , Haijun ZHANG , Li ZHANG , Xiu WANG , Jin CHANG . Research progress on the engineering construction of biomimetic auricle reconstruction prosthesis[J]. The Journal of Practical Medicine, 2025 , 41(12) : 1767 -1774 . DOI: 10.3969/j.issn.1006-5725.2025.12.001
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