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Research progress of Rho GTPase activating protein for regulator of tumor cell migration
Received date: 2025-02-16
Online published: 2025-06-19
Rho GTPase-activating proteins （ARHGAP） constitute a family of multifunctional regulatory proteins that negatively regulate Rho family GTPases （e.g.， RhoA， Rac1， Cdc42） by accelerating the hydrolysis bound to these enzymes. Members of this family are extensively involved in crucial biological processes such as cellular signal transduction， adhesion， and dynamic reorganization of cytoskeleton， while also playing significant roles in tumor progression. ARHGAP expression and function vary across cancer types， with identical molecule exhibiting divergent expression levels and biological effects in various malignancies. The regulatory effects of ARHGAP family members on tumor cell migration are closely associated with their unique structural domain characteristics and are modulated by multiple signaling pathways. This paper comprehensively analyzes and summarizes existing research to explore the roles and mechanisms of ARHGAP family members in tumor cell migration， aiming to identify potential biomarkers and therapeutic targets in cancer management and prevention.
Key words： ARHGAP; Rho GTPase; tumor; migration; signaling pathway
Shihan CHEN , Yong JI , Wei ZHU . Research progress of Rho GTPase activating protein for regulator of tumor cell migration[J]. The Journal of Practical Medicine, 2025 , 41(11) : 1751 -1759 . DOI: 10.3969/j.issn.1006-5725.2025.11.021
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