The Journal of Practical Medicine >

2025 , Vol. 41 >Issue 11: 1718 - 1723

DOI: https://doi.org/10.3969/j.issn.1006-5725.2025.11.016

Drugs and Clinic Practice

Influence of oxycodone-acetaminophen combined with local radiotherapy on serum cytokines in elderly patients with malignant tumor bone metastasis complicated with cancer pain

  • Minghong SHI ,
  • Zhanwei LIU ,
  • Yang ZHU ,
  • Lili XIA ,
  • Gang CHENG ,
  • Youguo LU
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  • *.Radiotherapy Department，Huainan Xinhua Medical Group Xinhua Hospital，Huainan 232000，Anhui，China

Received date: 2025-02-17

  Online published: 2025-06-19

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Abstract

Objective To investigate the influence of combination of oxycodone-acetaminophen and local radiotherapy on serum cytokines in elderly patients with malignant tumor bone metastasis and cancer pain. Methods Eighty elderly patients with malignant tumor bone metastasis and cancer pain admitted to Huainan Xinhua Medical Group Xinhua Hospital from January 2020 to April 2024 were divided into control group （40 cases） and observation group （40 cases） according to the order of admission. The control group received codeine combined with local radiotherapy， whereas the observation group was treated with oxycodone-acetaminophen combined with local radiotherapy. Pain relief （assessed using visual analogue scale （VAS））， daily fulminant pain occurrence frequency and occurrence of adverse reactions during treatment as well as serum cytokines ［substance P （SP）， prostaglandinE2 （PGE2）， interleukin-6 （IL-6）］， sleep quality （assessed using Pittsburgh sleep quality index （PSQI）） and quality of life ［assessed using functional assessment of cancer therapy-general （FACT-G）］ before and after treatment were compared between the two groups.. Results The pain relief effect in the observation group was better （P < 0.05）， and the daily occurrence frequency of fulminant pain was less than that in the control group （P < 0.05）. After treatment， serum levels of SP， PGE2 and IL-6 in the observation group were lower compared to those in the control group （P < 0.05）. The total incidence rate of bone-related events during treatment was not significantly different between the two groups （P > 0.05）， and the total incidence rate of adverse reactions was lower in the observation group compared to those in the control group （P < 0.05）. The PSQI score in the observation group after treatment was lower （P < 0.05） while the scores of physiology and emotion of FACT-G were higher compared to those in the control group （P < 0.05）. Conclusion Oxycodone-acetaminophen combined with local radiotherapy can down-regulate the levels of serum SP， PGE2 and IL-6， relieve the pain， and improve the sleep quality and quality of life in elderly patients with malignant tumor bone metastasis complicated with cancer pain.

Key words： malignant tumor; bone metastasis; cancer pain; elderly; oxycodone-acetaminophen; radiotherapy; prostaglandinE2; interleukin-6

Cite this article

Minghong SHI , Zhanwei LIU , Yang ZHU , Lili XIA , Gang CHENG , Youguo LU . Influence of oxycodone-acetaminophen combined with local radiotherapy on serum cytokines in elderly patients with malignant tumor bone metastasis complicated with cancer pain[J]. The Journal of Practical Medicine, 2025 , 41(11) : 1718 -1723 . DOI: 10.3969/j.issn.1006-5725.2025.11.016

References

1 DEO S V S， SHARMA J， KUMAR S. GLOBOCAN 2020 Report on Global Cancer Burden： Challenges and Opportunities for Surgical Oncologists［J］.Ann Surg Oncol， 2022， 29（11）：6497-6500. doi:10.1245/s10434-022-12151-6
2 阴毅然，谢雁鸣，赵晓晓，等. 真实世界中榄香烯乳状注射液治疗骨转移癌患者临床特征，联合用药规律分析［J］. 中成药， 2023， 45（3）：1031-1036.
3 中国医师协会肿瘤医师分会乳腺癌学组，中国抗癌协会国际医疗交流分会. 骨改良药物用于恶性肿瘤骨转移治疗的安全性共识（2024版）［J］. 中华肿瘤杂志， 2024， 46（7）：637-645.
4 赖桂花，王菲，聂多锐，等. 骨转移癌痛发病机制及中医药防治研究进展［J］. 中国实验方剂学杂志， 2023， 29（11）：231-239.
5 杨森，赵华新，王朝昕，等. 华蟾素胶囊和芬太尼透皮贴剂联合治疗肿瘤骨转移中重度癌痛的效果研究［J］. 中国全科医学， 2019， 22（32）：3993-3996，4001.
6 CHU X， ZHUANG H， LIU Y， et al. Blocking Cancer-Nerve Crosstalk for Treatment of Metastatic Bone Cancer Pain［J］. Adv mater （Deerfield Beach， Fla.）， 2022， 34（17）：e2108653. doi:10.1002/adma.202108653
7 郭环宇，陈卓，李众，等. 小半夏汤加味联合格拉司琼防治阿片类药物引起癌痛患者恶心，呕吐的临床观察［J］. 中国老年学杂志， 2022， 42（19）：4656-4659.
8 SCHATTNER A， GLICK Y. Opioid analgesics， faecal stones and rectosigmoid perforation［J］. Postgrad Med J， 2020， 97（1154）：760-761. doi:10.1136/postgradmedj-2020-138960
9 MARTIN L F， ALMUSLIM M， ISMAIL K A， et al. The conotoxin Contulakin-G reverses hypersensitivity observed in rodent models of cancer-induced bone pain without inducing tolerance or motor disturbance［J］. Pain， 2025， 166（2）：376-387. doi:10.1097/j.pain.0000000000003391
10 石磊，熊慧华，杨琳，等. 氨酚羟考酮片用于宫颈癌疼痛控制的疗效观察［J］. 中国新药杂志， 2008， 17（21）：1884-1885.
11 YANG X， YOU L， JIN D， et al. A community-based cross-sectional study of sleep quality among internal migrant workers in the service industry［J］.Compr Psychiatry， 2019， 97：152154. doi:10.1016/j.comppsych.2019.152154
12 HASTERT T A， KYKO J M， REED A R， et al. Financial Hardship and Quality of Life among African American and White Cancer Survivors： The Role of Limiting Care Due to Cost［J］.Cancer Epidemiol Biomarkers Prev， 2019， 28（7）：1202-1211. doi:10.1158/1055-9965.epi-18-1336
13 李永红. 前列腺癌骨转移诊疗专家共识解读.中华腔镜泌尿外科杂志（电子版），2024，18（5）： 530-530.
14 孙鸣，高斌，张建春. 姑息性放疗联合三阶梯止痛方案在老年骨转移疼痛患者中应用及预后随访［J］. 中国老年学杂志， 2023， 43（1）：41-44.
15 CRUSH J， LEVY N， KNAGGS R D， et al. Misappropriation of the 1986 WHO analgesic ladder： the pitfalls of labelling opioids as weak or strong［J］. Br J Anaesth， 2022， 129（2）：137-142. doi:10.1016/j.bja.2022.03.004
16 VOSS E A， ALI S R， SINGH A，et al. Hip Fracture Risk After Treatment with Tramadol or Codeine： An Observational Study［J］.Drug Saf， 2022， 45（7）：791-807. doi:10.1007/s40264-022-01198-9
17 ALLEY A， COWLES S， RANGAN P， et al. The Effect of an Automated Order on Postpartum Opioid Use After Uncomplicated Vaginal Deliveries［J］. J Women's Health （2002）， 2022， 31（6）：842-847.
18 BAMBERGER J N， GALLANTE B， KHUSID J A， et al. A prospective randomized study evaluating the necessity of narcotics following ureteroscopy for urinary stone disease［J］. World J Urol， 2022， 40（10）：2567-2573. doi:10.1007/s00345-022-04099-9
19 PALOCHAK C M A， REED D S， APSEY D A， et al. Pain Control Following Photorefractive Keratectomy： A Prospective Clinical Trial Comparing Codeine Versus Oxycodone for the Management of Postoperative Pain［J］. J Refract Surg， 2021， 37（9）：582-589. doi:10.3928/1081597x-20210701-01
20 TEOH L， MCCULLOUGH M， TAING M W. Efficacy of oxycodone for postoperative dental pain： A systematic review and meta-analysis［J］. J Dent， 2022， 125：104254. doi:10.1016/j.jdent.2022.104254
21 张萌，谭朝阳，陈沁怡，等. 普瑞巴林联合氨酚羟考酮治疗带状疱疹后遗神经痛的效果［J］. 广东医学， 2018， 39（6）：920-922.
22 万复甦，董爽，蔡茜，等. 低剂量氨酚羟考酮片与可待因治疗中度骨转移癌痛的随机对照研究［J］. 肿瘤防治研究， 2019， 46（7）：632-634.
23 王丽，方玉甫，徐俊涛，等. 基于Th1/Th2失衡和血清P物质探讨刺络拔罐联合中药湿敷治疗带状疱疹的作用机制［J］. 针刺研究， 2022， 47（9）：814-820.
24 汪华英，许莹，郭生红，等. 清胆利肝方治疗肝经郁热型带状疱疹临床疗效及对患者T淋巴细胞亚群，血清疼痛物质P，PGE2的影响［J］. 中国老年学杂志， 2024， 44（5）：1083-1087.
25 侯公瑾，柏正平，曾普华，等. 蟾龙镇痛膏对骨转移性癌痛模型大鼠疼痛阈值及血清PGE2，TNF-α，IL-6，β-EP的影响［J］. 中药新药与临床药理， 2019， 30（10）：1222-1227.
26 SWARM R A， PAICE J A， ANGHELESCU D L， et al. Adult Cancer Pain， Version 3.2019， NCCN Clinical Practice Guidelines in Oncology［J］. J Natl Compr Canc Netw， 2019， 17（8）：977-1007.
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