The Journal of Practical Medicine >

2025 , Vol. 41 >Issue 10: 1533 - 1539

DOI: https://doi.org/10.3969/j.issn.1006-5725.2025.10.015

Clinical Research

Development and validation of a predictive model for delayed neurological sequelae in acute carbon monoxide poisoning

  • Shaolin LI ,
  • Xiaohong MA ,
  • Dehe ZHANG ,
  • Peng. SONG
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  • *.Department of Rehabilitation Medicine，Xinxiang Central Hospital（the Fourth Clinical College of Xinxiang Medical College），Xinxiang 453000，Henan，China

Received date: 2024-11-18

  Online published: 2025-05-21

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Abstract

Objective To construct a predictive model for delayed neurological sequelae （DNS） following acute carbon monoxide poisoning （ACMP） and to verify its efficacy. Methods A retrospective analysis of the general data of 183 patients with ACMP was conducted. The factors influencing the occurrence of DNS were analyzed using a multivariate Logistic regression model. A corresponding predictive model was then established and its efficacy was verified. Results The multivariate logistic regression model showed that age， smoking history， severe poisoning， blood lactate， time from poisoning to hyperbaric oxygen therapy， and pulmonary infection were independent risk factors for DNS following ACMP （P < 0.05）. The area under the curve （AUC） of the model for predicting DNS in the development set was 0.933， with a sensitivity of 94.12% and specificity of 89.77%. In the validation set， the AUC was 0.906， with a sensitivity of 90.00% and specificity of 92.68%. The Hosmer-Lemeshow test showed that the predicted probabilities of DNS in both the development and validation sets were not significantly different from the actual probabilities （P > 0.05）. The predictive model achieved clinical net benefit within the risk threshold ranges of 0.11 ~ 0.98 for the development set and 0.12 ~ 0.92 for the validation set. Conclusions Age， smoking history， severe poisoning， blood lactate， time from poisoning to hyperbaric oxygen therapy， and pulmonary infection are independent risk factors for DNS following ACMP. The corresponding predictive model has been verified to have good clinical efficacy.

Key words： acute carbon monoxide poisoning; delayed neurological sequelae; predictive model; nomogram

Cite this article

Shaolin LI , Xiaohong MA , Dehe ZHANG , Peng. SONG . Development and validation of a predictive model for delayed neurological sequelae in acute carbon monoxide poisoning[J]. The Journal of Practical Medicine, 2025 , 41(10) : 1533 -1539 . DOI: 10.3969/j.issn.1006-5725.2025.10.015

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