The Journal of Practical Medicine >

2025 , Vol. 41 >Issue 5: 699 - 703

DOI: https://doi.org/10.3969/j.issn.1006-5725.2025.05.012

Clinical Research

Effect of intra⁃aortic balloon counterpulsation combined with rhBNP on ventricular remodeling in elderly patients with acute anterior myocardial infarction before emergency PCI

  • Shengbo LI ,
  • Ling FENG ,
  • Beibei CHEN ,
  • Fang YAO ,
  • Yongsheng XING ,
  • Yanbin. LIU
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  • *.Cardiovascular Intensive Care Unit of Xinxiang Central Hospital，Xinxiang 453000，Henan，China

Received date: 2024-10-30

  Online published: 2025-03-20

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Abstract

Objective The effect of intra?aortic balloon counterpulsation combined with recombinant human brain natriuretic peptide （rhBNP） treatment on ventricular remodeling after percutaneous coronary intervention （PCI） in elderly patients with acute anterior wall myocardial infarction. Methods A retrospective analysis was conducted on 66 elderly patients with acute anterior myocardial infarction who underwent emergency PCI in our hospital from January 2018 to June 2023. They were divided into a control group （n = 32） who underwent PCI + rhBNP， and a study group （n = 32） who underwent PCI+rhBNP+intra?aortic balloon counterpulsation. Blood pressure， lactic acid level， mechanical complications， ventricular remodeling， inflammatory factors， myocardial enzymology， ox?LDL level were detected and compared between the two groups. Results Before treatment， Lactic acid， diastolic blood pressure， systolic blood pressure， left ventricular end?systolic diameter （LVESD）， left ventricular end?diastolic diameter （LVEDD）， left ventricular posterior wall thickness （LVPWT）， left ventricular remodeling index （LVRI）， left ventricular ejection fraction （LVEF）， homocysteine （Hcy）， interleukin?6 （IL?6） and myocardial troponin were compared between the two groups. Myocardial troponin T （cTnT）， lactate dehydrogenase （LDH）， creatine kinase isoenzyme （CK?MB）， oxidized low density lipoprotein （ox?LDL） levels （P > 0.05）； At 3 months follow?up after discharge， the levels of lactic acid， LVESD， LVEDD， LVPWT， LVRI， Hcy， IL?6， cTnT， LDH， CK?MB and ox?LDL were decreased， and the levels were lower in the study group， and the levels of diastolic blood pressure， systolic blood pressure and LVEF were increased， and the levels were higher in the study group （P < 0.05）. The proportion of mechanical complications between the two groups before and after treatment were compared （P > 0.05）. Conclusion In elderly patients with acute anterior myocardial infarction after emergency PCI， intra?aortic balloon counterpulsation combined with rhBNP could alleviate ventricular remodeling， myocardial injury， reduce inflammatory injury， improve oxidative stress response， and regulate tissue perfusion.

Key words： intra?aortic balloon counterpulsation; recombinant human brain natriuretic peptide; acute anterior myocardial infarction; percutaneous coronary intervention; ventricular remodeling

Cite this article

Shengbo LI , Ling FENG , Beibei CHEN , Fang YAO , Yongsheng XING , Yanbin. LIU . Effect of intra⁃aortic balloon counterpulsation combined with rhBNP on ventricular remodeling in elderly patients with acute anterior myocardial infarction before emergency PCI[J]. The Journal of Practical Medicine, 2025 , 41(5) : 699 -703 . DOI: 10.3969/j.issn.1006-5725.2025.05.012

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