The Journal of Practical Medicine >
Progress in endoscopic treatment of benign esophageal stenosis
Received date: 2024-11-21
Online published: 2025-02-28
Esophageal stenosis primarily refers to the narrowing of the esophageal lumen caused by intrinsic esophageal diseases or their complications， categorized into benign and malignant types. Benign esophageal stenosis can arise from congenital factors or secondary conditions such as postoperative changes following esophageal cancer surgery， esophagitis， and other inflammatory processes. This condition is characterized by dysphagia， significantly impacting patients′ quality of life and imposing substantial economic and medical burdens on society. Effective prevention and management of benign esophageal stenosis have emerged as an urgent medical challenge. With advancements in endoscopic techniques， various interventions including endoscopic dilation， endoscopic mucosal resection， endoscopic stenting， and regenerative medicine have been applied to treat benign esophageal stenosis， achieving promising therapeutic outcomes. In recent years， regenerative medicine has gained prominence， promoting early re?epithelialization through the structural and functional reconstruction of normal tissues， offering potential applications in the prevention and treatment of benign esophageal stenosis. However， selecting an appropriate treatment method for benign esophageal stenosis requires a comprehensive evaluation of the patient′s condition， therapeutic efficacy， potential complications， recurrence rates， and other relevant factors. This review aims to summarize the current progress in endoscopic treatments for benign esophageal stenosis， providing valuable insights for clinical practice.
Tiantian HUANG , Chong. WANG . Progress in endoscopic treatment of benign esophageal stenosis[J]. The Journal of Practical Medicine, 2025 , 41(4) : 465 -470 . DOI: 10.3969/j.issn.1006-5725.2025.04.002
| 1 | MIZUSAWA T， KOBAYASHI M， TERAI S，et al. Radial incision and cutting for refractory benign esophageal stricture［J］. Dig Endosc，2019，31：e46-e47. doi:10.1111/den.13329 |
| 2 | 张海静，胡海清. 食管吻合口良性狭窄治疗方法的临床进展［J］. 中华胃肠内镜电子杂志，2019，6（1）：27-31. |
| 3 | SAMI S S， HABOUBI H N，ANG Y，et al. UK guidelines on oesophageal dilatation in clinical practice［J］. Gut，2018，67（6）：1000-1023. doi:10.1136/gutjnl-2017-315414 |
| 4 | 李红科，陈根峰，李建杰，等. 可取出食管支架植入术和内镜下探条扩张术治疗难治性食管狭窄的临床效果［J］. 临床医学研究与实践，2019，4（7）：53-55. doi:10.19347/j.cnki.2096-1413.201907022 |
| 5 | 仇振伍，赵峰，沙正布. 内镜下食管扩张术对不同病因所致食管狭窄的临床疗效［J］. 徐州医科大学学报，2023，43（3）：205-208. |
| 6 | KOCHHAR R， MALIK S， REDDY Y R，et al. Outcomes of Endoscopic Dilation in Patients with Esophageal Anastomotic Strictures： Comparison Between Different Etiologies［J］. Dysphagia，2020，35（1）：73-83. doi:10.1007/s00455-019-10004-1 |
| 7 | VAN HALSEMA E E， NOORDZIJ I C， VAN BERGE HENEGOUWEN M I，et al. Endoscopic dilation of benign esophageal anastomotic strictures over 16 mm has a longer lasting effect［J］. Surg Endosc，2017，31（4）：1871-1881. doi:10.1007/s00464-016-5187-0 |
| 8 | VERMEULEN B D， DE ZWART M， SIJBEN J，et al. Risk factors and clinical outcomes of endoscopic dilation in benign esophageal strictures： A long-term follow-up study［J］. Gastrointest Endosc，2020，91（5）：1058-1066. doi:10.1016/j.gie.2019.12.040 |
| 9 | 蔡华波，王朝霞. 儿童食管狭窄球囊扩张术［J］. 中国实用儿科杂志，2023，38（12）：893-895. |
| 10 | 李果，杨凤娟，郭杏杏，等. 数字减影血管造影引导梯度压力法分阶段球囊扩张治疗食管癌吻合口狭窄的效果及对营养指标的影响观察［J］. 实用医学杂志，2023，39（13）：1657-1662. doi:10.3969/j.issn.1006-5725.2023.13.011 |
| 11 | 彭海玲，谭玉勇，刘德良. 难治性食管良性狭窄的内镜下治疗进展［J］. 中华消化内镜杂志，2022，39（2）：159-163. doi:10.3760/cma.j.cn321463-20201114-00895 |
| 12 | 王璐，陈磊，朱振，等. 内镜下放射状切开治疗食管ESD术后狭窄的临床研究［J］. 临床消化病杂志，2023，35（3）：181-185. doi:10.3870/lcxh.j.issn.1005-541X.2023.03.004 |
| 13 | 郭斌，樊宇芳，李二峰，等. 内镜下放射状切开治疗难治性食管胃吻合口良性狭窄效果观察［J］. 肿瘤研究与临床，2022，34（9）：698-699. |
| 14 | 龙思泽，曹磊，白一景，等. 内镜下放射状切开术与球囊扩张术治疗食管吻合口良性狭窄的对比研究［J］. 国际消化病杂志，2019，39（5）：363-365. |
| 15 | PIH G Y， KIM D H， NA H K，et al. Comparison of the Efficacy and Safety of Endoscopic Incisional Therapy and Balloon Dilatation for Esophageal Anastomotic Stricture［J］. J Gastrointest Surg，2021，25（7）：1690-1695. doi:10.1007/s11605-020-04811-3 |
| 16 | ZHU Y， SHRESTHA S M， YU T， et al. Modified endoscopic radial incision and cutting method （M-RIC） for the treatment of refractory esophageal stricture［J］. Surg Endosc，2022，36（2）：1385-1393. doi:10.1007/s00464-021-08423-z |
| 17 | HUANG Z， WEI W， CHENG F. Endoscopic radial incision method for two strictures of the esophagus after endoscopic submucosal dissection：A case report［J］. World J Surg Oncol，2020，18（1）：38. doi:10.1186/s12957-020-01812-z |
| 18 | MA X， ZHANG X， LI B， et al. Endoscopic Stricturotomy in the Treatment of Refractory Esophageal Anastomotic Strictures［J］. Dysphagia，2023，38（2）：650-656. doi:10.1007/s00455-022-10495-5 |
| 19 | TAKADA J，UNO Y， KOJIMA K，et al. Radial incision and cutting for post-esophageal endoscopic submucosal dissection stricture with prior perforation during dilation［J］. Endoscopy，2023，55（S 1）：E1238-E1239. doi:10.1055/a-2208-5744 |
| 20 | 胡亦懿，杜国平，李国华，等. 内镜超声引导下反向切开术治疗食管良性难治性狭窄的初步应用［J］. 中华消化内镜杂志，2020，37（8）：558-561. |
| 21 | 刘佩璐，沈磊. 消化道良性狭窄的内镜下治疗进展［J］. 临床消化病杂志，2023，35（5）：417-422. |
| 22 | WALTER D， VAN DEN BERG M W， HIRDES M M，et al. Dilation or biodegradable stent placement for recurrent benign esophageal strictures： A randomized controlled trial［J］. Endoscopy，2018，50（12）：1146-1155. doi:10.1055/a-0602-4169 |
| 23 | SHI K D， JI F. Prophylactic stenting for esophageal stricture prevention after endoscopic submucosal dissection［J］. World J Gastroenterol， 2017，23（6）：931-934. doi:10.3748/wjg.v23.i6.931 |
| 24 | LIU L L， QIN J， ZENG C H，et al. Biodegradable PTX-PLGA-coated magnesium stent for benign esophageal stricture： An experimental study［J］. Acta Biomater，2022，146：495-505. doi:10.1016/j.actbio.2022.04.038 |
| 25 | YANO T， YODA Y， NONAKA S，et al. Pivotal trial of a biodegradable stent for patients with refractory benign esophageal stricture［J］. Esophagus，2022，19（3）：516-524. doi:10.1007/s10388-022-00909-6 |
| 26 | YANG Y， YANG Y， HOU Z，et al. Comprehensive review of materials， applications， and future innovations in biodegradable esophageal stents［J］. Front Bioeng Biotechnol，2023，11：1327517. doi:10.3389/fbioe.2023.1327517 |
| 27 | ZHANG Y， WANG Q， XU Y，et al. Mitomycin C Inhibits Esophageal Fibrosis by Regulating Cell Apoptosis and Autophagy via lncRNA-ATB and miR-200b［J］. Front Mol Biosci，2021，8：675757. doi:10.3389/fmolb.2021.675757 |
| 28 | ZHAN K， WANG P， LIU W H，et al. Submucosal steroid pre-injection strategy to prevent oesophageal stricture after circumferential endoscopic submucosal dissection［J］. Gut，2024，73（11）：1780-1784. doi:10.1136/gutjnl-2024-333098 |
| 29 | 陈龙平，郑林福，陈志平，等. 内镜下放射状切开联合局部注射曲安奈德治疗食管良性狭窄的疗效观察［J］. 中国内镜杂志，2023，29（8）：72-77. |
| 30 | CARPENTIER D， ENGLEBERT G， OTERO SANCHEZ L，et al. Local triamcinolone injection and selective add-on oral steroids to prevent esophageal post-endoscopic submucosal dissection stricture： A retrospective analysis in a Western center［J］. Endoscopy，2024，56（11）：811-819. doi:10.1055/a-2328-6282 |
| 31 | ZHOU S， CHEN X， FENG M，et al. Efficacy of different steroid therapies in preventing esophageal stricture after endoscopic submucosal dissection： A comparative meta-analysis［J］. Gastrointest Endosc，2024，100（6）：1020-1033.e3. doi:10.1016/j.gie.2024.08.017 |
| 32 | KADOTA T， YODA Y， HORI K，et al. Prophylactic steroid administration against strictures is not enough for mucosal defects involving the entire circumference of the esophageal lumen after esophageal endoscopic submucosal dissection （ESD）［J］. Esophagus， 2020，17（4）：440-447. doi:10.1007/s10388-020-00730-z |
| 33 | QIU Y， SHI R. Roles of Steroids in Preventing Esophageal Stricture after Endoscopic Resection［J］. Can J Gastroenterol Hepatol，2019，2019：5380815. doi:10.1155/2019/5380815 |
| 34 | SAWIRES H， AESKANDER A， EL-SAYED M，et al. Early topical mitomycin-C prevents stricture formation in children with caustic ingestion［J］. J Paediatr Child Health，2024，60（9）：402-408. doi:10.1111/jpc.16595 |
| 35 | 李纯纯，陈炳芳，张银. 丝裂霉素治疗食管良性狭窄的临床应用进展［J］. 实用医学杂志，2021，37（11）：1377-1381. |
| 36 | MARTíNEK J， JUHAS S， DOLEZEL R，et al. Prevention of esophageal strictures after circumferential endoscopic submucosal dissection［J］. Minerva Chir，2018，73（4）：394-409. doi:10.23736/s0026-4733.18.07751-9 |
| 37 | REN K， WANG J， LI Y，et al. Paclitaxel-coated balloon catheter for benign esophageal stenosis in a rabbit model［J］. Sci Rep，2024，14（1）：2551. doi:10.1038/s41598-024-53078-0 |
| 38 | 俞姝含，李文杰. 组织工程和再生医学在预防内镜黏膜下剥离术后食管狭窄的研究进展［J］. 现代消化及介入诊疗，2021，26（10）：1211-1215. |
| 39 | WANG J， ZHAO Y， LI P，et al. Advances in The Application of Regenerative Medicine in Prevention of Post-endoscopic Submucosal Dissection for Esophageal Stenosis［J］. J Transl Int Med，2022，10（1）：28-35. doi:10.2478/jtim-2022-0011 |
| 40 | WANG H， SHUAI Q， TANG J，et al. Local Thymosin β4 Gel Injection Prevents Esophageal Stricture after Circumferential Endoscopic Submucosal Dissection in a Porcine Model［J］.Dig Dis，2019，37（2）：87-92. doi:10.1159/000492216 |
| 41 | COFFIN E， GRANGIER A， PERROD G，et al. Extracellular vesicles from adipose stromal cells combined with a thermoresponsive hydrogel prevent esophageal stricture after extensive endoscopic submucosal dissection in a porcine model［J］. Nanoscale，2021，13（35）：14866-14878. doi:10.1039/d1nr01240a |
| 42 | CHUNG H， AN S， HAN S Y，et al. Endoscopically injectable and self-crosslinkable hydrogel-mediated stem cell transplantation for alleviating esophageal stricture after endoscopic submucosal dissection［J］. Bioeng Transl Med，2023，8（3）：e10521. doi:10.1002/btm2.10521 |
| 43 | LIU Y， DOU L， SONG T，et al. Successful prevention of post-endoscopic submucosal dissection esophageal stenosis by using autologous buccal mucosa with polyglycolic acid and self-help inflatable balloon［J］. Gastrointest Endosc，2024，99（5）：841-842. doi:10.1016/j.gie.2023.11.024 |
| 44 | FU X Y， JIANG Z Y， ZHANG C Y，et al. New hope for esophageal stricture prevention： A prospective single-center trial on acellular dermal matrix［J］. World J Gastrointest Endosc，2023，15（12）：725-734. doi:10.4253/wjge.v15.i12.725 |
| 45 | 王文玲，王佩，韩艳妙，等. 自体黏膜移植预防早期食管癌近环周内镜下黏膜剥离术后食管狭窄的疗效观察［J］. 中华医学杂志，2023，103（9）：684-688. |
| 46 | FUJINO A， FUCHIMOTO Y， MORI T，et al. Evaluation of safety and efficacy of autologous oral mucosa-derived epithelial cell sheet transplantation for prevention of anastomotic restenosis in congenital esophageal atresia and congenital esophageal stenosis［J］. Stem Cell Res Ther，2023，14（1）：86. doi:10.1186/s13287-023-03321-8 |
| 47 | KOBAYASHI S， KANAI N， YAMATO M，et al. Allogeneic transplantation of epidermal cell sheets followed by endoscopic submucosal dissection to prevent severe esophageal stricture in a porcine model［J］. Regen Ther，2022，21：157-165. doi:10.1016/j.reth.2022.06.008 |
| 48 | ZHANG Y， MAO X L， ZHU W，et al. Esophageal Mucosal Autograft for Preventing Stricture After Widespread Endoscopic Submucosal Dissection of Superficial Esophageal Lesions［J］. Turk J Gastroenterol，2022，33（4）：312-319. |
| 49 | LIAO Z， LIAO G， YANG X，et al. Transplantation of autologous esophageal mucosa to prevent stricture after circumferential endoscopic submucosal dissection of early esophageal cancer （with video）［J］. Gastrointest Endosc，2018，88（3）：543-546. doi:10.1016/j.gie.2018.04.2349 |
| 50 | HOCHBERGER J， KOEHLER P， WEDI E，et al. Transplantation of mucosa from stomach to esophagus to prevent stricture after circumferential endoscopic submucosal dissection of early squamous cell［J］. Gastroenterology，2014，146（4）：906-909. doi:10.1053/j.gastro.2014.01.063 |
| 51 | MARUYA Y， AKAZAWA Y， NORIMATSU K，et al. Long-term prognosis and DNA damage status after oral mucosal epithelial cell sheet transplantation following esophageal endoscopic submucosal dissection for squamous cell carcinoma： A case series［J］. Regen Ther，2024，26：557-563. doi:10.1016/j.reth.2024.08.007 |
| 52 | LIU Y， LI Z， DOU L，et al. Autologous esophageal mucosa with polyglycolic acid transplantation and temporary stent implantation can prevent stenosis after circumferential endoscopic submucosal dissection［J］. Ann Transl Med，2021，9：546. doi:10.21037/atm-20-6987 |
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