Reviews

Research progress of ultrasound microbubbles in diagnosis and treatment of thyroid cancer

  • Kui XU ,
  • Jun. ZHOU
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  • Department of Ultrasound,the Second People′s Hospital of China Three Gorges University,Yichang 443000,Hubei,China

Received date: 2024-08-26

  Online published: 2025-02-19

Abstract

Ultrasonic microbubbles are vesicles withgas core stabilized by a shell comprised of lipids, proteins, and polymer materials. It can be used not only as a contrast agent to diagnose the disease and monitor the pathological process at the molecular level, but also as a carrier of non-invasive treatment, carrying drugs or genes to the region of interest through blood circulation, thereby exerting therapeutic effects. Compared with traditional diagnosis and treatment methods, ultrasound microbubbles show great potential. Targeted imaging and treatment can identify specific types of tumors in the early stage, and improve the prognosis by reducing the systemic toxicity of chemotherapy drugs while enhancing the anti-tumor efficacy. This provides a new idea and strategy for future diagnosis and treatment of thyroid cancer. This article reviews the application of ultrasound microbubbles in the diagnosis and treatment of thyroid cancer.

Cite this article

Kui XU , Jun. ZHOU . Research progress of ultrasound microbubbles in diagnosis and treatment of thyroid cancer[J]. The Journal of Practical Medicine, 2025 , 41(3) : 454 -458 . DOI: 10.3969/j.issn.1006-5725.2025.03.023

References

1 HU S, WU X, JIANG H. Trends and projections of the global burden of thyroid cancer from 1990 to 2030[J]. J Glob Health, 2024, 14: 4084. doi:10.7189/jogh.14.04084
2 ZHOU X, GUO L, SHI D, et al. Biocompatible Chitosan Nanobubbles for Ultrasound-Mediated Targeted Delivery of Doxorubicin[J]. Nanoscale Res Lett, 2019, 14(1): 24. doi:10.1186/s11671-019-2853-x
3 JANGJOU A, MEISAMI A H, JAMALI K, et al. The promising shadow of microbubble over medical sciences: from fighting wide scope of prevalence disease to cancer eradication[J]. J Biomed Sci, 2021, 28(1): 49. doi:10.1186/s12929-021-00744-4
4 LIANG X, CHEN W, WANG C, et al. A mesoporous theranostic platform for ultrasound and photoacoustic dual imaging-guided photothermal and enhanced starvation therapy for cancer[J]. Acta Biomater, 2024, 183: 264-277. doi:10.1016/j.actbio.2024.05.040
5 PISCAGLIA F, BOLONDI L. The safety of Sonovue in abdominal applications: retrospective analysis of 23188 investigations[J]. Ultrasound Med Biol, 2006, 32(9): 1369-1375. doi:10.1016/j.ultrasmedbio.2006.05.031
6 BALOCH Z W, ASA S L, BARLETTA J A, et al. Overview of the 2022 WHO Classification of Thyroid Neoplasms[J]. Endocr Pathol, 2022, 33(1): 27-63. doi:10.1007/s12022-022-09707-3
7 LEONG D, GILL A J, TURCHIINI J, et al. The Prognostic Impact of Extent of Vascular Invasion in Follicular Thyroid Carcinoma[J]. World J Surg, 2023, 47(2): 412-420. doi:10.1007/s00268-022-06696-6
8 PELIZZO M R, MAZZA E I, MIAN C, et al. Medullary thyroid carcinoma[J]. Expert Rev Anticancer Ther, 2023, 23(9): 943-957. doi:10.1080/14737140.2023.2247566
9 MANIAKAS A, ZAFEREO M, CABANILLAS M E. Anaplastic Thyroid Cancer: New Horizons and Challenges[J]. Endocrinol Metab Clin North Am, 2022, 51(2): 391-401. doi:10.1016/j.ecl.2021.11.020
10 HVILSOM G B, LONDERO S C, HAHN C H, et al. Anaplastic thyroid carcinoma in Denmark 1996-2012: A national prospective study of 219 patients[J]. Cancer Epidemiol, 2018, 53: 65-71. doi:10.1016/j.canep.2018.01.011
11 BAUD G, JANNIN A, MARCINIAK C, et al. Impact of Lymph Node Dissection on Postoperative Complications of Total Thyroidectomy in Patients with Thyroid Carcinoma[J]. Cancers (Basel), 2022, 14(21):5462. doi:10.3390/cancers14215462
12 FACKELMAYER O J, INABNET W R. Lobectomy or Total Thyroidectomy-Where Is the Pendulum now for Differentiated Thyroid Cancer?[J]. Surg Oncol Clin N Am, 2023, 32(2): 373-381. doi:10.1016/j.soc.2022.10.011
13 ZHOU L, LI S, WU Y, et al. Significant dysregulation of lipid metabolism in patients with papillary thyroid carcinoma after thyroidectomy[J]. Front Endocrinol (Lausanne), 2023, 14: 1223527. doi:10.3389/fendo.2023.1223527
14 AHN S H, LEE Y J, HONG S, et al. Risk of Fractures in Thyroid Cancer Patients With Postoperative Hypoparathyroidism:A Nationwide Cohort Study in Korea[J]. J Bone Miner Res, 2023, 38(9): 1268-1277. doi:10.1002/jbmr.4871
15 MULITA F, VERRAS G I, DAFNOMILI V D, et al. Thyroidectomy for the Management of Differentiated Thyroid Carcinoma and their Outcome on Early Postoperative Complications: A 6-year Single-Centre Retrospective Study[J].Chirurgia (Bucur), 2022, 117(5): 556-562. doi:10.21614/chirurgia.2736
16 TEMPERLEY T S, TEMPERLEY H C, O'SULLIVAN N J, et al. Tracheoesophageal fistula development following radiotherapy and tyrosine kinase inhibitors in a patient with advanced follicular thyroid carcinoma: a case-based review[J]. Ir J Med Sci, 2024, 193(3): 1143-1147. doi:10.1007/s11845-023-03559-4
17 TUTTLE R M, AHUJA S, AVRAM A M, et al. Controversies,Consensus,and Collaboration in the Use of(131)ITherapy in Differentiated Thyroid Cancer: A Joint Statement from the American Thyroid Association, the European Association of Nuclear Medicine, the Society of Nuclear Medicine and Molecular Imaging, and the European Thyroid Association[J]. Thyroid, 2019, 29(4): 461-470. doi:10.1089/thy.2018.0597
18 SHANGGUAN L, ZHANG P, FANG S, et al. Preliminary Study on the Relationship of BRAF Mutations with the Outcome of theFirst(131)IRadiotherapy and Malignant Biological Characteristics in Papillary Thyroid Carcinoma[J]. Int J Gen Med, 2021, 14: 8981-8989. doi:10.2147/ijgm.s337311
19 CHEN M, ZHANG K Q, XU Y F, et al. Shear wave elastography and contrast-enhanced ultrasonography in the diagnosis of thyroid malignant nodules[J]. Mol Clin Oncol, 2016, 5(6): 724-730. doi:10.3892/mco.2016.1053
20 AVERKIOU M A, BRUCE M F, Powers J E, et al. Imaging Methods for Ultrasound Contrast Agents[J]. Ultrasound Med Biol, 2020, 46(3): 498-517. doi:10.1016/j.ultrasmedbio.2019.11.004
21 MINE Y, TAKADA E, SUGIMOTO K, et al. Principle of contrast-enhanced ultrasonography[J]. J Med Ultrason (2001), 2024,51(4):691. doi:10.1007/s10396-024-01500-5
22 ZHOU X, ZHOU P, HU Z, et al. Diagnostic Efficiency of Quantitative Contrast-Enhanced Ultrasound Indicators for Discriminating BenignFromMalignant Solid Thyroid Nodules[J]. J Ultrasound Med, 2018, 37(2): 425-437. doi:10.1002/jum.14347
23 PETRASOVA H, SLAISOVA R, ROHAN T, et al. Contrast-Enhanced Ultrasonography for Differential Diagnosis of Benign and Malignant Thyroid Lesions: Single-Institutional Prospective Study of Qualitative and Quantitative CEUS Characteristics[J]. Contrast Media Mol Imaging, 2022, 2022: 8229445. doi:10.1155/2022/8229445
24 ZHAO H, LIU X, LEI B, et al. Diagnostic performance of thyroid imaging reporting and data system (TI-RADS) alone and in combination with contrast-enhanced ultrasonography for the characterization of thyroid nodules[J]. Clin Hemorheol Microcirc, 2019, 72(1): 95-106. doi:10.3233/ch-180457
25 杨霞, 付敏, 王洋.甲状腺肿瘤微血管密度与超声表现的相关性[J]. 实用癌症杂志, 2019, 34(7): 1147-1149.
26 TRIMBOLI P, CASTELLANA M, VIRILI C, et al. Performance of contrast-enhanced ultrasound (CEUS) in assessing thyroid nodules: A systematic review and meta-analysis using histological standard of reference[J].RadiolMed, 2020, 125(4): 406-415. doi:10.1007/s11547-019-01129-2
27 LIN Y, WU Y. Trends in incidence and overdiagnosis of thyroid cancer in China, Japan, and South Korea[J]. Cancer Sci, 2023, 114(10): 4052-4062. doi:10.1111/cas.15909
28 WANG D, XING C, LIANG Y, et al. Ultrasound Imaging of Tumor Vascular CD93 with MMRN2 Modified Microbubbles for Immune Microenvironment Prediction[J]. Adv Mater, 2024, 36(18): e2310421. doi:10.1002/adma.202470134
29 DIAKOVAG B, WANG M, UNNIKRISHNAN S, et al. Preparation and Characterization of Targeted Microbubbles[J]. J Vis Exp, 2021(175). doi:10.3791/62370
30 MA J, WANG Y, XI X, et al. Contrast-enhanced ultrasound combined targeted microbubbles for diagnosis of highly aggressive papillary thyroid carcinoma[J]. Front Endocrinol (Lausanne), 2023, 14: 1052862. doi:10.3389/fendo.2023.1052862
31 XIE F, YAN L, LI Y M, et al. Targeting Diagnosis of High-Risk Papillary Thyroid Carcinoma Using Ultrasound Contrast Agent With the BRAF(V600E) Mutation: An Experimental Study[J]. J Ultrasound Med, 2022, 41(11): 2789-2802. doi:10.1002/jum.15967
32 HE J, LIU Z, ZHU X, et al. Ultrasonic Microbubble Cavitation Enhanced Tissue Permeability and Drug Diffusion in Solid Tumor Therapy[J]. Pharmaceutics, 2022, 14(8):1642. doi:10.3390/pharmaceutics14081642
33 LIN Y C, CHEN H C, CHEN H K, et al. Ultrastructural Changes AssociatedWiththe Enhanced Permeability of the Round Window Membrane Mediated by Ultrasound Microbubbles[J]. Front Pharmacol, 2019, 10: 1580. doi:10.3389/fphar.2019.01580
34 TZU-YIN W, WILSON K E, MACHTALER S, et al. Ultrasound and microbubble guided drug delivery: Mechanistic understanding and clinical implications[J]. Curr Pharm Biotechnol, 2013, 14(8): 743-752. doi:10.2174/1389201014666131226114611
35 YANG Y U, BAI W, CHEN Y, et al. Optimization of low-frequency low-intensity ultrasound-mediated microvessel disruption on prostate cancer xenografts in nude mice using an orthogonal experimental design[J]. Oncol Lett, 2015, 10(5): 2999-3007. doi:10.3892/ol.2015.3716
36 LEI W, CHANG S, TIAN F, et al. Numerical simulation study on opening blood-brain barrier by ultrasonic cavitation[J]. Ultrason Sonochem, 2024, 109: 107005. doi:10.1016/j.ultsonch.2024.107005
37 刘婷婷, 罗德钦, 邓铖, 等. 受体酪氨酸激酶样孤儿素受体2在甲状腺乳头状癌中的表达及临床意义[J]. 实用医学杂志, 2023, 39(8): 985-990. doi:10.3969/j.issn.1006-5725.2023.08.012
38 MARANO F, FRAIRIA R, RINELLA L, et al.Combining doxorubicin-nanobubbles and shockwaves for anaplastic thyroid cancer treatment: Preclinical study in a xenograft mouse model[J]. Endocr Relat Cancer, 2017, 24(6): 275-286. doi:10.1530/erc-17-0045
39 彭云, 温美玲, 吕云霞, 等. LncRNA DSCAM-AS1调节miR-150-5p/BRAF轴对甲状腺癌细胞恶性生物学行为的影响[J]. 实用医学杂志, 2023, 39(23): 3043-3050. doi:10.3969/j.issn.1006-5725.2023.23.004
40 ZHU Y, ARKIN G, ZENG W, et al. Ultrasound image-guided cancer gene therapy using iRGD dual-targeted magnetic cationic microbubbles[J]. Biomed Pharmacother, 2024, 172: 116221. doi:10.1016/j.biopha.2024.116221
41 CHEN X, ZHANG X, QIAN Y, et al. Ultrasound-targeted microbubble destruction-mediated miR-144-5p overexpression enhances the anti-tumor effect of paclitaxel on thyroid carcinoma by targeting STON2[J]. Cell Cycle, 2022, 21(10): 1058-1076. doi:10.1080/15384101.2022.2040778
42 ZHANG Y, QIU N, ZHANG Y, et al. Oxygen-carrying nanoparticle-based chemo-sonodynamic therapy for tumor suppression and autoimmunity activation[J]. Biomater Sci, 2021, 9(11): 3989-4004. doi:10.1039/d1bm00198a
43 XIANG Y, BERNARDS N, HOANG B, et al. Perfluorocarbon nanodroplets can reoxygenate hypoxic tumors in vivo without carbogen breathing[J]. Nanotheranostics, 2019, 3(2): 135-144. doi:10.7150/ntno.29908
44 WANG Q, SUI G, WU X, et al. A sequential targeting nanoplatform for anaplastic thyroid carcinoma theranostics[J]. Acta Biomater, 2020, 102: 367-383. doi:10.1016/j.actbio.2019.11.043
45 GUAN S, TENG D, WANG H, et al. Multifunctional Phase-Transition Nanoparticles for Effective Targeted Sonodynamic-Gene Therapy Against Thyroid Papillary Carcinoma[J]. Int J Nanomedicine, 2023, 18: 2275-2293. doi:10.2147/ijn.s394504
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