The Journal of Practical Medicine >

2025 , Vol. 41 >Issue 1: 95 - 99

DOI: https://doi.org/10.3969/j.issn.1006-5725.2025.01.016

Drugs and Clinic Practice

The effect of aspirin on frozen thawed embryo transfer in endometriosis with thin endometrium

  • Min ZHOU ,
  • Xiaoxiao ZHANG ,
  • Zhao WU
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  • Center for Reproductive Medicine，Department of Obstetrics and Gynecology，Sichuan Provincial People's Hospital，School of Medicine，University of Electronic Science and Technology of China，Chengdu 610072，Sichuan，China

Received date: 2024-05-06

  Online published: 2025-01-14

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Abstract

Objective To analyze the effect of aspirin addition on endometrial conditions and pregnancy outcomes in endometriosis-related patients with thin endometrium. Methods A retrospective analysis was conducted on endometriosis-related patients with thin endometrium （thickness < 7 mm） undergoing frozen-thawed embryo transfer at the Reproductive Medical Centre from January 2019 to May 2023 was conducted. Patients undergoing hormone replacement therapy with aspirin （Observation group， n = 162） were compared with those receiving increased estrogen alone （Control group， n = 152）. Endometrial parameters before embryo transfer and clinical outcomes were compared between the groups. Results Compared to the Control group， the Observation group showed significant improvements in pulsatility index （PI） ［（0.77 ± 0.20） vs. （0.84 ± 0.27），P < 0.05］， resistance index （RI） ［（0.49 ± 0.10） vs. （0.63 ± 0.10），P < 0.01］， and systolic/diastolic （S/D） ratio ［（1.94 ± 0.49） vs. （2.22 ± 0.47），P < 0.01］. Moreover， there was a significant increase in the embryo implantation rate （38.00% vs. 27.24%， P < 0.01）， clinical pregnancy rate （56.17% vs. 42.11%， P < 0.05） and live birth rate （84.62% vs. 68.75%， P < 0.05）. Conclusion In endometriosis-related patients with thin endometrium， the addition of aspirin significantly improved uterine and spiral artery blood flow， thereby enhancing pregnancy outcomes during frozen-thawed embryo transfer.

Key words： endometriosis; thin endometrium; aspirin; frozen embryo transfer

Cite this article

Min ZHOU , Xiaoxiao ZHANG , Zhao WU . The effect of aspirin on frozen thawed embryo transfer in endometriosis with thin endometrium[J]. The Journal of Practical Medicine, 2025 , 41(1) : 95 -99 . DOI: 10.3969/j.issn.1006-5725.2025.01.016

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