Clinical Research

Predictive value of mini-fluid challenge test in elderly orthopedic patients with hypotension after subarachnoid block

  • Changning LIANG ,
  • Xiaoping CHEN ,
  • Jingjing WEI ,
  • Yali GE ,
  • Ju GAO
Expand
  • Department of Anesthesiology,Clinical Medical College of Yangzhou University Northern Jiangsu People′s Hospital,Yangzhou 225000,Jiangsu,China

Received date: 2024-10-16

  Online published: 2025-01-14

Abstract

Objective To investigate the predictive value of the mini?fluid challenge test in elderly orthopedic patients for post?spinal anesthesia hypotension. Methods Seventy?two elderly patients who underwent elective hip or knee replacement surgery were rigorously screened according to predefined inclusion and exclusion criteria. All patients were scheduled for subarachnoid block anesthesia. Subjects were grouped based on changes in blood pressure within 15 minutes of assuming a supine position following single?shot lumbar anesthesia. According to previously established definitions of hypotension, they were categorized into either the hypotension group (H group) or the normal blood pressure group (N group). Prior to spinal anesthesia, a mini?fluid challenge test was conducted using noninvasive cardiac output monitoring to measure the change in stroke volume index (ΔSVI), and baseline circulatory data were recorded. Multivariate logistic regression analysis was employed to identify factors influencing outcomes in elderly patients undergoing orthopedic joint replacement surgery. Receiver operating characteristic (ROC) curves for ΔSVI were constructed, and the area under the curve (AUC) was calculated to evaluate its predictive performance. Results After spinal anesthesia, 29 patients (40.27%) experienced hypotension. Compared with Group N, patients in Group H who experienced hypotension within 15 minutes while in a supine position were significantly older, had a higher proportion of ASA grade III, and a higher prevalence of hypertension (P < 0.05). The analysis results indicated that ΔSVI was an independent influencing factor for post?lumbar anesthesia hypotension in elderly patients. ΔSVI demonstrated a sensitivity of 82.8% and a specificity of 81.4% in predicting post?spinal anesthesia hypotension (PSAH) at a cut?off value of 0.805 or greater. There was a moderate positive linear correlation between the maximum decrease in systolic blood pressure (SBP) and ΔSVI (r = 0.562, P < 0.01). Conclusion The mini?fluid challenge test is an effective method for predicting hypotension in elderly orthopedic patients following spinal anesthesia.

Cite this article

Changning LIANG , Xiaoping CHEN , Jingjing WEI , Yali GE , Ju GAO . Predictive value of mini-fluid challenge test in elderly orthopedic patients with hypotension after subarachnoid block[J]. The Journal of Practical Medicine, 2025 , 41(1) : 60 -64 . DOI: 10.3969/j.issn.1006-5725.2025.01.010

References

1 IBRAHIM S S, PATIL B. A Comparative Study of Infusion of Ephedrine and Phenylephrine on Hemodynamic Stability After Spinal Anesthesia in Elderly Patients Undergoing Lower Limb Orthopedic Surgeries[J]. Cureus, 2024,16(9):e69977.
2 李泰佯,张磊,李莹,等. 不同剂量布比卡因蛛网膜下腔阻滞对老年患者髋部手术低血压的影响[J]. 临床麻醉学杂志,2023,39(3):260-265.
3 FENG S, GU J, YU C, et al. Exploring the predictive value of combined ultrasound parameters for spinal anesthesia-induced hypotension in cesarean section: A prospective observational study[J]. BMC Anesthesiol,2023,23(1):255. doi:10.1186/s12871-023-02160-7
4 DAI S, WANG C, TAO X,et al. Predicting fluid responsiveness in spontaneously breathing parturients undergoing caesarean section via carotid artery blood flow and velocity time integral measured by carotid ultrasound: A prospective cohort study[J]. BMC Pregnancy Childbirth,2024,24(1):60. doi:10.1186/s12884-024-06246-z
5 KIM H J, CHOI Y S, KIM S H,et al. Predictability of preoperative carotid artery-corrected flow time for hypotension after spinal anaesthesia in patients undergoing caesarean section: a prospective observational study[J]. Eur J Anaesthesiol, 2021,38(4):394-401. doi:10.1097/eja.0000000000001376
6 MARIK P E, BARAM M, VAHID B. Does central venous pressure predict fluid responsiveness: A systematic review of the literature and the tale of seven mares[J]. Chest,2008,134: 172-178. doi:10.1378/chest.07-2331
7 王倩,疏树华,许辉,等. 不同每搏变异度指导的液体治疗对老年全膝关节置换患者止血带相关低血压的影响[J]. 实用医学杂志,2022,38(22):2817-2821.
8 MESSINA A, LA VIA L, MILANI A,et al. Spinal anesthesia and hypotensive events in hip fracture surgical repair in elderly patients: A meta-analysis[J]. J Anesth Analg Crit Care,2022,2(1):19. doi:10.1186/s44158-022-00047-6
9 HOLLMANN C, FERNANDES N L, BICCARD B M. A systematic review of outcomes associated with withholding or continuing angiotensin-converting enzyme inhibitors and angiotensin receptor blockers before noncardiac surgery[J].Anesth Analg,2018,127:678-687. doi:10.1213/ane.0000000000002837
10 KIM H J, CHOI Y S, KIM S H, et al. Predictability of preoperative carotid artery-corrected flow time for hypotension after spinal anaesthesia in patients undergoing caesarean section: A prospective observational study[J]. Eur J Anaesthesiol,2021,38(4):394-401. doi:10.1097/eja.0000000000001376
11 JAKOBSSON J, KALMAN S H, LINDEBERG-LINDVET M, et al. Is postspinal hypotension a sign of impaired cardiac performance in the elderly? An observational mechanistic study[J]. Br J Anaesth,2017,119(6):1178-1185. doi:10.1093/bja/aex274
12 LI L, HE L X, YAO Y T. Evidence in Cardiovascular Anesthesia (EICA) Group. The efficacy and safety of pre-emptive methoxamine infusion in preventing hypotension by in elderly patients receiving spinal anesthesia: A PRISMA-compliant protocol for systematic review and meta-analysis[J]. Medicine (Baltimore),2022,101(49):e32262. doi:10.1097/md.0000000000032262
13 MOSCHOVAKI N, SARANTEAS T, SPILIOTAKI E, et al. Point of care transthoracic echocardiography for the prediction of post - spinal anesthesia hypotension in elderly patients with cardiac diseases and left ventricular dysfunction : Inferior vena cava and post-spinal anesthesia hypotension in elderly patients[J]. J Clin Monit Comput,2023,37(5):1207-1218. doi:10.1007/s10877-023-00981-y
14 陈柏蓉. 探讨无创心排出量监测在危重病患者中的应用价值[J]. 中外医疗,2021,40(23):188-190.
15 MINVILLE V, ASEHNOUNE K, SALAU S, et al. The effects of spinal anesthesia on cerebral blood flow in the very elderly[J]. Anesth Analg,2009,108: 1291-1294. doi:10.1213/ane.0b013e31819b073b
16 K?L?? Y, BAS S S, KAYHAN G E, et al. Internal Jugular Vein Ultrasonography in Prediction of Postspinal Hypotension[J]. J Coll Physicians Surg Pak,2020,30(12):1256-1261. doi:10.29271/jcpsp.2020.12.1256
17 HOLLMANN C, FERNANDES N L, BICCARD B M. A systematic review of outcomes associated with withholding or continuing angiotensin-converting enzyme inhibitors and angiotensin receptor blockers before noncardiac surgery[J].Anesth Analg,2018, 127:678-687. doi:10.1213/ane.0000000000002837
18 WU F, LIANG T, XIAO W, et al. Norepinephrine in Goal-Directed Fluid Therapy During General Anesthesia in Elderly Patients Undergoing Spinal Operation: Determining Effective Infusion Rate to Enhance Postoperative Functions[J]. Curr Genomics,2021,22(8):620-629. doi:10.2174/1389202922666211213104944
Outlines

/