Diabetic glomerulosclerosis is a kind of glomerular disease dominated by vascular damage， mainly related to the inflammatory state of the body. Intestinal flora and its metabolites can influence kidney disease through a variety of metabolic pathways. Early identification of high⁃risk groups of diabetic glomerulosclerosis could delay the progression of diabetic nephropathy. This article focused on the relationship between the intestinal micro⁃ biota and diabetic glomerulosclerosis，aiming to clarify the interaction between the intestinal flora and its metabo⁃ lites and diabetic glomerulosclerosis. Also，we tried to explore the use of exogenous supplementary probiotics as a new method to treat diabetic glomerulosclerosis.