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Research progress of bone morphogenetic protein signaling pathway in central nervous system
Received date: 2024-06-26
Online published: 2025-01-14
Bone morphogenetic proteins are a large subclass of the transforming growth factor β family， and Their signaling pathways are mainly classified into two kinds based on whether they depend on Smad protein to mediate or not. BMP signaling pathways are involved in regulating cell proliferation and differentiation， as well as the formation and development of multiple tissues and organs. Recent studies have shown that BMP signaling pathways mainly promote the differentiation and growth of neurons and astrocytes， and are closely related to the myelination of oligodendrocytes. In addition， BMP signaling pathways also play an important role in the occurrence of central nervous system diseases， such as spinal cord injuries， multiple sclerosis， neural tube defects， and Parkinson's disease. This article reviews the BMP signaling pathways' composition， transduction mechanism and their role in the central nervous system and related diseases， in order to provide more potential ideas for basic research and clinical treatment of central nervous system diseases.
Yingying GAN , Min HU , Shuya CUI , Zhi CHAI , Huijie FAN . Research progress of bone morphogenetic protein signaling pathway in central nervous system[J]. The Journal of Practical Medicine, 2025 , 41(1) : 141 -145 . DOI: 10.3969/j.issn.1006-5725.2025.01.023
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