The Journal of Practical Medicine >
Relationship between changes of serum neurotransmitters and stress hormones and secondary brain injury during acute cerebral hemorrhage
Received date: 2024-03-19
Online published: 2024-12-16
Objective To investigate the relationship between the changes of serum neurotransmitters and stress hormones and secondary brain injury （SBI） in acute stage of cerebral hemorrhage. Methods The data of 149 patients with intracerebral hemorrhage admitted to the hospital from January 2020 to December 2023 were retrospectively analyzed. The patients with intracerebral hemorrhage who developed SBI 5 days after treatment were divided into the group with SBI and the group without SBI. Serum neurotransmitters and stress hormones were measured before treatment and 3 days after treatment. The levels of serum neurotransmitters and stress hormones in patients with and without SBI were compared， the factors affecting the occurrence of SBI were analyzed， and the value of serum neurotransmitters and stress hormones in predicting the occurrence of SBI in patients with cerebral hemorrhage was analyzed. Results Logistic regression analysis showed acute physiological and chronic health status score Ⅱ， cerebral hemorrhage volume， gamma-aminobutyric acid （GABA） level and adrenocorticotropin releasing hormone （CRH） were the factors affecting the complication of SBI in patients with cerebral hemorrhage （P < 0.05）. ROC curve analysis results showed that the sensitivity of GABA， CRH and their combined prediction of SBI in patients with cerebral hemorrhage were 68.29%， 70.73% and 85.37%， the specificity was 70.37%， 72.22% and 89.81%， and the AUC was 0.708 （95%CI： 0.604 ~ 0.813）， 0.711 （95%CI： 0.597 ~ 0.825）， 0.882 （95%CI： 0.812 ~ 0.951）. Conclusion Serum neurotransmitter GABA and stress hormone CRH are related to the complication of SBI in patients with cerebral hemorrhage， and the combination of GABA and CRH is effective in predicting the complication of SBI in patients with cerebral hemorrhage.
Han XU , Yue LU , Pu. YUAN . Relationship between changes of serum neurotransmitters and stress hormones and secondary brain injury during acute cerebral hemorrhage[J]. The Journal of Practical Medicine, 2024 , 40(23) : 3343 -3348 . DOI: 10.3969/j.issn.1006-5725.2024.23.010
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