The Journal of Practical Medicine >

2024 , Vol. 40 >Issue 22: 3196 - 3201

DOI: https://doi.org/10.3969/j.issn.1006-5725.2024.22.013

Clinical Research

The clinical value of NLRP3 inflammasome level combined with ECP/MPO ratio in predicting the recurrence of chronic sinusitis after endoscopic sinus surgery

  • Juanjuan FENG ,
  • Zexing CHENG ,
  • Lu XIAO
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  • Department of Otolaryngology，Head and Neck Surgery，Affiliated Hospital of Yangzhou University，Yangzhou 225000，Jiangsu，China

Received date: 2024-03-28

  Online published: 2024-11-25

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Abstract

Objective To explore the clinical value of NOD-like receptor pyrin domain-containing protein 3 （NLRP3） inflammasome levels combined with eosinophil cationic protein （ECP）/myeloperoxidase （MPO） ratio in predicting the recurrence of chronic rhinosinusitis after endoscopic sinus surgery. Methods 205 patients with chronic sinusitis who received treatment from the hospital from February 2018 to December 2022 after endoscopic sinus surgery were selected for prospective analysis. The patients were divided into non-recurrence group and recurrence group according to whether they relapsed one year after surgery.The factors influencing the recurrence of patients with chronic sinusitis after endoscopic sinus surgery were screened， and the predictive efficacy was evaluated by receiver operating characteristic curve （ROC）. Results The NLRP3 inflammasome level， ECP/MPO ratio， sinus CT score， Lund-Kennedy score and immunoglobulin E in the relapsing group were higher than non-relapsing group （P < 0.05）. NLRP3 inflammasome level， ECP/MPO ratio， sinus CT score， Lund-Kennedy score and immunoglobulin E were the influencing factors of postoperative recurrence in patients with chronic sinusitis （P < 0.05）. The area under the curve （AUC） values of NLRP3 inflammasome level， ECP/MPO ratio and combined prediction of postoperative recurrence in patients with chronic sinusitis were 0.823， 0.815 and 0.899， respectively （P < 0.05）， and the AUC value of combined NLRP3 was higher （P < 0.05）. Conclusion NLRP3 inflammasome level combined with ECP/MPO ratio has a high value in predicting the risk of recurrence after nasal endoscopy.

Key words： sinusitis; NOD-like receptor heat protein domain associated protein 3; eosinophilic cationic protein; myeloperoxidase; nasal endoscopy; recurrence; predictive value

Cite this article

Juanjuan FENG , Zexing CHENG , Lu XIAO . The clinical value of NLRP3 inflammasome level combined with ECP/MPO ratio in predicting the recurrence of chronic sinusitis after endoscopic sinus surgery[J]. The Journal of Practical Medicine, 2024 , 40(22) : 3196 -3201 . DOI: 10.3969/j.issn.1006-5725.2024.22.013

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