Objective To observe the effect of goal ⁃directed fluid therapy based on maximum stroke volume in replantation of severed fingers. Methods Forty ASAⅠ-Ⅱ patients，aged 18 to 60，were randomly divided into two groups according to different experimental methods ：normal control group（group C）and goal⁃ directed fluid therapy group（group G），20 for each group. Mean arterial pressure（MAP），stroke volume（SV） and cardiac output（CO）were recorded at the time points of entering the operating room（T0），before surgery（T1） and at the end of surgery（T2）. Radial artery blood was collected at T1 and T2 to detect blood lactic acid（Lac）， IL⁃1β and IL⁃10. Results The amount of colloid input in group G was significantly higher than that in group C （P < 0.05），but there was no significant difference in the amount of crystalloid fluid input（P > 0.05）；the values of MAP，SV，CO，Lac，IL⁃1β and IL⁃6 in radial artery blood between the two groups at T1 and T2 were statistically significant（P < 0.05）. Conclusions Application of goal⁃directed fluid therapy based on maximum stroke volume in replantation of severed fingers can maintain hemodynamic stability，dynamically optimize microcirculation perfu⁃ sion，reduce arterial blood lactic acid concentration，inhibit expressions of IL⁃1β and IL⁃6 inflammatory factors，