The Journal of Practical Medicine >
The research progress of macrophage glycolysis in sepsis
Received date: 2024-02-25
Online published: 2024-10-22
Sepsis is a heterogeneous syndrome. It is caused by infections， attributing to immune dysfunction pathologically. The disease is characterized by macrophage-mediated inflammation and immune response throughout its development. During septic development， macrophages metabolize crucially with glycolysis remarkably enhanced. The glycolystic enhancement facilitates septic development by promoting the inflammatory response of macrophages and altering their phenotype. Therefore， direct or indirect inhibition of macrophagic glycolysis can alleviate sepsis and neutralize damages to organs functionally， promoting the polarization of anti-inflammatory phenotype. In this review， we aim to investigate the relationship between macrophagic glycolysis and sepsis， focusing on researching into relevant molecular mechanisms by which glycolysis is regulated for treating sepsis. It is concluded that interfering with macrophagic glycolysis may serve as a novel therapeutic strategy for treating sepsis.
Key words： sepsis; macrophage; glycolysis
Xing CAI , Xinglong MA , Changjian ZHOU , Peng XIE , Songxuan SHEN , Yanmei MIAO , Jiamei SONG , Leiyu. XIE . The research progress of macrophage glycolysis in sepsis[J]. The Journal of Practical Medicine, 2024 , 40(19) : 2783 -2788 . DOI: 10.3969/j.issn.1006-5725.2024.19.020
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