The Journal of Practical Medicine >

2024 , Vol. 40 >Issue 19: 2708 - 2712

DOI: https://doi.org/10.3969/j.issn.1006-5725.2024.19.008

Clinical Research

Association between miRNA-146a gene polymorphisms and ischemic post-stroke depression

  • Jiawu FU ,
  • Hao WU ,
  • Zhimin LIAO ,
  • Jing CHEN ,
  • Junliang. LI
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  • Department of Neurology，Guangdong Medical University Hospital，Zhanjiang 524000，Guangdong，China

Received date: 2024-01-30

  Online published: 2024-10-22

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Abstract

Objective To analyze the relationship of miRNA-146a gene polymorphisms and ischemic post-stroke depression （PSD）. Methods The SNP rs2910164 in the miRNA-146a gene in 200 ischemic PSD patients （case group） and 200 ischemic non-PSD patients （control group） was analyzed using the SNaPshot technique. The relative expression levels of miRNA-146a in the peripheral blood of two groups were determined. Results The case group showed significantly different allele and genotype frequencies of the SNP rs2910164 as compared with the control group （G vs. C： P = 0.003； GG + CG vs. CC： P = 0.012）. Meanwhile， the case group presented a significantly lower level of miRNA-146a relative expression （P < 0.05）. Within the control group， additionally， the subgroup of GG + CG genotypes demonstrated a significantly lower level of miRNA-146a relative expression compared with the subgroup of CC genotypes （P < 0.05）. Conclusion SNP rs2910164 in the miRNA-146ais associated with the susceptibility to ischemic PSD， and G allele may play a role in the ischemic PSD.

Key words： miRNA-146a; ischemic post-stroke depression; gene polymorphisms; relative expression

Cite this article

Jiawu FU , Hao WU , Zhimin LIAO , Jing CHEN , Junliang. LI . Association between miRNA-146a gene polymorphisms and ischemic post-stroke depression[J]. The Journal of Practical Medicine, 2024 , 40(19) : 2708 -2712 . DOI: 10.3969/j.issn.1006-5725.2024.19.008

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