Objective To investigate the current status of frailty in patients on maintenance hemodialysis （MHD）， and explore the correlation of frailty with anxiety and depression. Methods General information， clinical data and blood biochemical data of 101 cases who underwent MHD in Department of Nephrology， Shunde Hospital Affiliated to Jinan University from January 2023 to January 2024 were collected. FRAIL scale was applied to evaluate the frailty of the patients， and they were accordingly classified into frailty group and non?frailty group （including pre?frail and non?frail participants）. Anxiety and depression were evaluated by GAD?7 and PHQ?9 scale. Univariate analysis and logistic regression were used to explore the association of frailty with anxiety， depression and other possible influencing factors. Results Among the 101 cases， 29 cases （28.71%） were includedin frailty group and 72 cases （71.29%） in non?frailty group. There were 42 patients with depression （41.58%） and 25 with anxiety （24.75%）. In the frailty group， the prevalence of depression was 65.52% and that of anxiety 55.17%。 There were significant differences in age， grip strength， exercise， stroke and coronary heart disease， anxiety and depression， ferritin and CRP between the two groups （P < 0.01）. Multivariate regression analysis showed that depression， anxiety， no exercise， stroke and high ferritin concentration were independent risk factors for frailty in MHD patients （P < 0.05）. Conclusion In patients on MHD， frailty is closely associated with depression， anxiety， and lack of exercise， and stroke as well as high ferritin concentration are independent risk factors for frailty。