The Journal of Practical Medicine >
Research progress of microplastics in the field of obesity
Received date: 2023-11-17
Online published: 2024-07-15
Overweight and obesity have emerged as a significant public health concern globally. While factors such as genetics， diet， and physical activity are insufficient to fully account for the rise in overweight and obesity， recent studies have indicated a link between environmental pollutants and the development of obesity. Microplastics， a novel type of environmental pollutant， are pervasive in various environmental media and daily life， entering organisms through multiple pathways including the digestive tract， respiratory tract， skin， among others. Evidence from studies has revealed the presence of microplastics in human tissues， organs， and biological samples， suggesting potential health risks to humans. This review outlines the pathways and distribution of microplastics within the human body while summarizing current research progress in relation to obesity. This article aims to raise awareness within society regarding the detrimental effects of microplastics and provide a theoretical foundation for medical professionals addressing public health issues.
Key words： microplastics; obesity; public health
Shulei ZHANG , Ruiji CUI , Lingjun YAN , Wei SUN , Yinglong. BAI . Research progress of microplastics in the field of obesity[J]. The Journal of Practical Medicine, 2024 , 40(14) : 1908 -1915 . DOI: 10.3969/j.issn.1006-5725.2024.14.002
| 1 | DESPRES J P， CARPENTIER A C， TCHERNOF A，et al. Management of obesity in cardiovascular practice： Jacc focus seminar［J］. J Am Coll Cardiol， 2021， 78（5）： 513-531. doi:10.1016/j.jacc.2021.05.035 |
| 2 | KHALIL W J， AKEBLERSANE M， KHAN A S，et al. Environmental pollution and the risk of developing metabolic disorders： Obesity and diabetes［J］. Int J Mol Sci， 2023， 24（10）： 8870. doi:10.3390/ijms24108870 |
| 3 | 国家卫生健康委员会. 中国卫生健康统计年鉴［M］. 北京：中国协和医科大学出版社， 2022. |
| 4 | 马敏东，赵洋尘，朱龙，等. 人体微塑料污染特征及健康风险研究进展［J］. 环境科学， 2024，45（1）：459-469. |
| 5 | PATEL M M， GOYAL B R， BHADADA S V，et al. Getting into the brain approaches to enhance brain drug delivery［J］. Cns Drugs， 2009， 23（1）： 35-58. doi:10.2165/0023210-200923010-00003 |
| 6 | EUROPE P. Plastics-the facts 2022［EB/OL］.［2023-11-17］. . |
| 7 | NATH J， PARVIN F， TAREQ S M. Bioaccumulation of microplastics in the edible tissues of fish collected from urban lakes of bangladesh： A potential exposure to public health［J］. Environ Sci Pollut Res Int， 2024，31（2）：2067-2078. doi:10.1007/s11356-023-31219-8 |
| 8 | AYDIN R B， YOZUKMAZ A， SENER I，et al. Occurrence of microplastics in most consumed fruits and vegetables from turkey and public risk assessment for consumers［J］. Life （Basel）， 2023， 13（8）： 1686. doi:10.3390/life13081686 |
| 9 | LIU Q， CHEN Z， CHEN Y，et al. Microplastics contamination in eggs： Detection， occurrence and status［J］. Food Chem， 2022， 397： 133771. doi:10.1016/j.foodchem.2022.133771 |
| 10 | LI H， ZHU L， MA M，et al. Occurrence of microplastics in commercially sold bottled water［J］. Sci Total Environ， 2023， 867： 161553. doi:10.1016/j.scitotenv.2023.161553 |
| 11 | PIRONTI C， RICCIARDI M， MOTTA O，et al. Microplastics in the environment： Intake through the food web， human exposure and toxicological effects［J］. Toxics， 2021， 9（9）： 224. doi:10.3390/toxics9090224 |
| 12 | ALI T， HABIB A， MUSKAN F，et al. Health risks posed by microplastics in tea bags： Microplastic pollution-a truly global problem［J］. Int J Surg， 2023， 109（3）： 515-516. doi:10.1097/js9.0000000000000055 |
| 13 | KADAC-CZAPSKA K， KNEZ E， GIERSZEWSKA M，et al. Microplastics derived from food packaging waste-their origin and health risks［J］. Materials （Basel）， 2023， 16（2）： 674. doi:10.3390/ma16020674 |
| 14 | SONG K， DING R， SUN C，et al. Microparticles and microplastics released from daily use of plastic feeding and water bottles and plastic injectors： Potential risks to infants and children in China［J］. Environ Sci Pollut Res Int， 2021， 28（42）： 59813-59820. doi:10.1007/s11356-021-14939-7 |
| 15 | VEIDIS E M， LABEAUD A D， PHILLIPS A A，et al. Tackling the ubiquity of plastic waste for human and planetary health［J］. Am J Trop Med Hyg， 2021， 106（1）： 12-14. doi:10.4269/ajtmh.21-0968 |
| 16 | COX K D， COVERNTON G A， DAVIES H L，et al. Human consumption of microplastics［J］. Environ Sci Technol， 2019， 53（12）： 7068-7074. doi:10.1021/acs.est.9b01517 |
| 17 | 耿阳，胡曼，张益宁，等. 中国居民经食物摄入和空气吸入微纳塑料暴露特征分析［J］. 中华疾病控制杂志， 2021，25（11）： 1245-1250，1308. doi:10.16462/j.cnki.zhjbkz.2021.11.002 |
| 18 | MOHAMED NOR N H， KOOI M， DIEPENS N J，et al. Lifetime accumulation of microplastic in children and adults［J］. Environ Sci Technol， 2021， 55（8）： 5084-5096. doi:10.1021/acs.est.0c07384 |
| 19 | DRIS R， GASPERI J， MIRANDE C，et al. A first overview of textile fibers， including microplastics， in indoor and outdoor environments［J］. Environ Pollut， 2017， 221： 453-458. doi:10.1016/j.envpol.2016.12.013 |
| 20 | FIELD D T， GREEN J L， BENNETT R，et al. Microplastics in the surgical environment［J］. Environ Int， 2022， 170： 107630. doi:10.1016/j.envint.2022.107630 |
| 21 | VIANELLO A， JENSEN R L， LIU L，et al. Simulating human exposure to indoor airborne microplastics using a breathing thermal manikin［J］. Sci Rep， 2019， 9（1）： 8670. doi:10.1038/s41598-019-45054-w |
| 22 | LEI K， QIAO F， LIU Q，et al. Microplastics releasing from personal care and cosmetic products in China［J］. Mar Pollut Bull， 2017， 123（1/2）： 122-126. doi:10.1016/j.marpolbul.2017.09.016 |
| 23 | GOUIN T， AVALOS J， BRUNNING l. Use of micro-plastic beads in cosmetic products in Europe and their estimated emissions to the North sea environment［J］. SOFW J， 2015， 141： 1-33. |
| 24 | BASHIR S M， KIMIKO S， MAK C W，et al. Personal care and cosmetic products as a potential source of environmental contamination by microplastics in a densely populated Asian city［J］. Front Mar Sci， 2021， 8：683482. doi:10.3389/fmars.2021.683482 |
| 25 | SHARMA S， CHATTERJEE S. Microplastic pollution， a threat to marine ecosystem and human health： A short review［J］. Environ Sci Pollut Res Int， 2017， 24（27）： 21530-21547. doi:10.1007/s11356-017-9910-8 |
| 26 | CELEBI SOZENER Z， OZBEY YUCEL U， ALTINER S，et al. The external exposome and allergies： From the perspective of the epithelial barrier hypothesis［J］. Front Allergy， 2022， 3： 887672. doi:10.3389/falgy.2022.887672 |
| 27 | ENGLAND N.NHS single-use plastics reduction campaign pledge［EB/OL］.［2023-11-17］.. |
| 28 | AZOUZ S， BOYLL P， SWANSON M，et al. Managing barriers to recycling in the operating room［J］. Am J Surg， 2019， 217（4）： 634-638. doi:10.1016/j.amjsurg.2018.06.020 |
| 29 | LEE B K， ELLENBECKER M J， MOURE-ERASO R. Analyses of the recycling potential of medical plastic wastes［J］. Waste Manag， 2002， 22（5）： 461-470. doi:10.1016/s0956-053x(02)00006-5 |
| 30 | WYSSUSEK K， KEYS M， LAYCOCK B，et al. The volume of recyclable polyethylene terephthalate plastic in operating rooms-a one-month prospective audit［J］. Am J Surg， 2020， 220（4）： 853-855. doi:10.1016/j.amjsurg.2020.05.011 |
| 31 | JIANG Y， HAN J C， NA J，et al. Exposure to microplastics in the upper respiratory tract of indoor and outdoor workers［J］. Chemosphere， 2022， 307（3）： 136067. doi:10.1016/j.chemosphere.2022.136067 |
| 32 | ABBASI S， TURNER A. Human exposure to microplastics： A study in Iran［J］. J Hazard Mater， 2021， 403： 123799. doi:10.1016/j.jhazmat.2020.123799 |
| 33 | JENNER L C， ROTCHELL J M， BENNETT R T，et al. Detection of microplastics in human lung tissue using muftir spectroscopy［J］. Sci Total Environ， 2022， 831： 154907. doi:10.1016/j.scitotenv.2022.154907 |
| 34 | HORVATITS T， TAMMINGA M， LIU B，et al. Microplastics detected in cirrhotic liver tissue［J］. EBio Medicine， 2022， 82： 104147. doi:10.1016/j.ebiom.2022.104147 |
| 35 | ZHAO Q， ZHU L， WENG J， et al. Detection and characterization of microplastics in the human testis and semen［J］. Sci Total Environ， 2023， 877：162713. doi:10.1016/j.scitotenv.2023.162713 |
| 36 | RAGUSA A， NOTARSTEFANO V， SVELATO A，et al. Raman microspectroscopy detection and characterisation of microplastics in human breastmilk［J］. Polymers （Basel）， 2022， 14（13）： 2700. doi:10.3390/polym14132700 |
| 37 | ROTCHELL J M， JENNER L C， CHAPMAN E，et al. Detection of microplastics in human saphenous vein tissue using muftir： A pilot study［J］. PLoS One， 2023， 18（2）： e0280594. doi:10.1371/journal.pone.0280594 |
| 38 | LESLIE H A， VAN VELZEN M J M， BRANDSMA S H，et al. Discovery and quantification of plastic particle pollution in human blood［J］. Environ Int， 2022， 163： 107199. doi:10.1016/j.envint.2022.107199 |
| 39 | WU D， FENG Y， WANG R，et al. Pigment microparticles and microplastics found in human thrombi based on raman spectral evidence［J］. J Adv Res， 2023， 49： 141-150. doi:10.1016/j.jare.2022.09.004 |
| 40 | LIU S J， LIU X Y， GUO J L，et al. The association between microplastics and microbiota in placentas and meconium： The first evidence in humans［J］. Environ Sci Technol. 2023， 57（46）：17774-17785. doi:10.1021/acs.est.2c04706 |
| 41 | ZHANG J J， WANG L， TRASANDE L，et al. Occurrence of polyethylene terephthalate and polycarbonate microplastics in infant and adult feces［J］. ES&T Letters， 2021， 8（11）： 989-994. doi:10.1021/acs.estlett.1c00559 |
| 42 | SCHWABL P， KOPPEL S， KONIGSHOFER P，et al. Detection of various microplastics in human stool a prospective case series［J］. Ann Inter Med， 2019， 171（7）： 453-457. doi:10.7326/m19-0618 |
| 43 | AMEREH F， AMJADI N， MOHSENI-BANDPEI A，et al. Placental plastics in young women from general population correlate with reduced foetal growth in IUGR pregnancies［J］. Environ Pollut， 2022， 314： 120174. doi:10.1016/j.envpol.2022.120174 |
| 44 | HRYCIW D H. Early life nutrition and the development of offspring metabolic health［J］. Int J Mol Sci， 2022， 23（15）： 8096. doi:10.3390/ijms23158096 |
| 45 | KANNAN K， VIMALKUMAR K. A review of human exposure to microplastics and insights into microplastics as obesogens［J］. Front Endocrinol （Lausanne）， 2021， 12： 724989. doi:10.3389/fendo.2021.724989 |
| 46 | ZHANG Y， NI F， HE J S，et al. Mechanistic insight into different adsorption of norfloxacin on microplastics in simulated natural water and real surface water［J］. Environ Pollut， 2021， 284： 117537. doi:10.1016/j.envpol.2021.117537 |
| 47 | LU L， WAN Z， LUO T，et al. Polystyrene microplastics induce gut microbiota dysbiosis and hepatic lipid metabolism disorder in mice［J］. Sci Total Environ， 2018， 631-632： 449-458. doi:10.1016/j.scitotenv.2018.03.051 |
| 48 | 谢琼，于慧慧，周长赫，等. 微纳米塑料在小鼠消化器官吸收分布及与脂肪亲和性［J］. 中国公共卫生， 2021，37（3）：446-450. doi:10.11847/zgggws1134472 |
| 49 | WANG Y， WEI Z， XU K，et al. The effect and a mechanistic evaluation of polystyrene nanoplastics on a mouse model of type 2 diabetes［J］. Food Chem Toxicol， 2023， 173： 113642. doi:10.1016/j.fct.2023.113642 |
| 50 | XIE L， CHEN T， LIU J，et al. Intestinal flora variation reflects the short-term damage of microplastic to the intestinal tract in mice［J］. Ecotoxicol Environ Saf， 2022， 246： 114194. doi:10.1016/j.ecoenv.2022.114194 |
| 51 | LI S， MA Y， YE S，et al. Polystyrene microplastics trigger hepatocyte apoptosis and abnormal glycolytic flux via ros-driven calcium overload［J］. J Hazard Mater， 2021， 417： 126025. doi:10.1016/j.jhazmat.2021.126025 |
| 52 | LUO T， WANG C， PAN Z，et al. Maternal polystyrene microplastic exposure during gestation and lactation altered metabolic homeostasis in the dams and their f1 and f2 offspring［J］. Environ Sci Technol， 2019， 53（18）： 10978-10992. doi:10.1021/acs.est.9b03191 |
| 53 | ZHAO J， GOMES D， JIN L，et al. Polystyrene bead ingestion promotes adiposity and cardiometabolic disease in mice［J］. Ecotoxicol Environ Saf， 2022， 232： 113239. doi:10.1016/j.ecoenv.2022.113239 |
| 54 | ZENG S L， LI S Z， XIAO P T，et al. Citrus polymethoxyflavones attenuate metabolic syndrome by regulating gut microbiome and amino acid metabolism［J］. Sci Adv， 2020， 6（1）： eaax6208. doi:10.1126/sciadv.aax6208 |
| 55 | FOURNIER E， LEVEQUE M， RUIZ P，et al. Microplastics： What happens in the human digestive tract？ First evidences in adults using in vitro gut models［J］. J Hazard Mater， 2023， 442： 130010. doi:10.1016/j.jhazmat.2022.130010 |
| 56 | ZHANG X， WEN K， DING D，et al. Size-dependent adverse effects of microplastics on intestinal microbiota and metabolic homeostasis in the marine medaka （oryzias melastigma）［J］. Environ Int， 2021， 151： 106452. doi:10.1016/j.envint.2021.106452 |
| 57 | HUANG H， WEI F， QIU S，et al. Polystyrene microplastics trigger adiposity in mice by remodeling gut microbiota and boosting fatty acid synthesis［J］. Sci Total Environ， 2023， 890： 164297. doi:10.1016/j.scitotenv.2023.164297 |
| 58 | ROMANO N， FISCHER H. Microplastics affected black soldier fly （hermetia illucens）pupation and short chain fatty acids［J］. J Appl Entomol， 2021， 145（7）： 731-736. doi:10.1111/jen.12887 |
| 59 | ARSYI M， BESRAL B， HERDAYATI M，et al. Antenatal care services and incidence of low birth weight： A comparison of demographic and health surveys in 4 ASEAN countries［J］. J Prev Med Public Health， 2022， 55（6）： 559-567. doi:10.3961/jpmph.22.316 |
| 60 | TINKOV A A， ASCHNER M， KE T，et al. Adipotropic effects of heavy metals and their potential role in obesity［J］. Fac Rev， 2021， 10： 32. doi:10.12703/r/10-32 |
| 61 | LI Y L， LV J， DU Z P，et al. The levels of phthalate exposure and associations with obesity in an elderly population in China［J］. Ecotoxicol Environ Saf， 2020， 201： 110749. doi:10.1016/j.ecoenv.2020.110749 |
| 62 | LIU B Y， LEHMLER H J， SUN Y B，et al. Association of bisphenol a and its substitutes， bisphenol f and bisphenol s， with obesity in united states children and adolescents［J］. Diabetes Metab J， 2019， 43（1）： 59-75. doi:10.4093/dmj.2018.0045 |
| 63 | CANO-SANCHO G， WAREMBOURG C， GUIL N，et al. Nutritional modulation of associations between prenatal exposure to persistent organic pollutants and childhood obesity： A prospective cohort study［J］. Environ Health Perspect， 2023， 131（3）： 37011. doi:10.1289/ehp11258 |
| 64 | DI CIAULA A， PORTINCASA P. Diet and contaminants： Driving the rise to obesity epidemics？［J］. Curr Med Chem， 2019， 26（19）： 3471-3482. doi:10.2174/0929867324666170518095736 |
| 65 | AMATO A A， WHEELER H B， BLUMBERG B. Obesity and endocrine-disrupting chemicals［J］. Endocr Connect， 2021， 10（2）： R87-R105. doi:10.1530/ec-20-0578 |
| 66 | WANG Y L， LEE Y H， HSU Y H，et al. The kidney-related effects of polystyrene microplastics on human kidney proximal tubular epithelial cells HK-2 and male C57BL/6 mice［J］. Environ Health Perspect， 2021， 129（5）： 57003. doi:10.1289/ehp7612 |
| 67 | RAWLE D J， DUMENIL T， TANG B，et al. Microplastic consumption induces inflammatory signatures in the colon and prolongs a viral arthritis［J］. Sci Total Environ， 2022， 809： 152212. doi:10.1016/j.scitotenv.2021.152212 |
| 68 | ZOU H， QU H Y， BIAN Y S，et al. Polystyrene microplastics induce oxidative stress in mouse hepatocytes in relation to their size［J］. Int J Mol Sci， 2023， 24（8）： 7382. doi:10.3390/ijms24087382 |
| 69 | HUANG T， ZHANG W J， LIN T T，et al. Maternal exposure to polystyrene nanoplastics during gestation and lactation induces hepatic and testicular toxicity in male mouse offspring［J］. Food Chem Toxicol， 2022， 160： 112803. doi:10.1016/j.fct.2021.112803 |
/
| 〈 |
|
〉 |