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Relationship between serum CTRP12 level and in⁃stent restenosis in patients with acute myocardial infarction after percutaneous coronary intervention
Received date: 2023-10-15
Online published: 2024-06-14
Objective To investigate changes in serum complement C1 tumor necrosis factor-related protein family 12 （CTRP12） level before and after percutaneous coronary intervention （PCI） in patients with acute myocardial infarction （AMI） and the relationship of CTRP12 level with in-stent restenosis （ISR）. Methods A total of 104 patients who had been diagnosed with AMI and had undergone PCI at Danyang People's Hospital in Jiangsu Province from January 2021 to June 2023 were selected. The incidence of ISR within 12 months after PCI was counted， and they were divided into an ISR group and a non-ISR group according to the results of reviewed coronary angiography. Serum CTRP12 levels were compared between the two groups before PCI and on one day before discharge. Logistic regression was used to analyze the influencing factors of ISR in AMI patients after PCI. Receiver operating characteristic （ROC） curve was used to analyze the predictive value of CTRP12 for ISR in AMI patients after PCI. Results The incidence of ISR in 104 AMI patients at 12 months after PCI was 14.4% （15/104）. As compared with the non-ISR group， the ISR group had significant increases in preoperative TIMI flow of ≤ 1， white blood cell count， neutrophil count， TC， and LDL-C， and a significant decline in serum CTRP12 level on one day before discharge （P < 0.05）. In the non-ISR group， serum CTRP12 level was significantly higher on one day before discharge than its baseline （P < 0.05）. In the ISR group， serum CTRP12 level on one day before discharge was lower than its baseline， but the difference was not statistically significant （P > 0.05）. Logistic regression analysis showed that a lower CTRP12 level on one day before discharge was an independent risk factor for ISR in AMI patients after PCI （P < 0.05）. ROC curve analysis showed that the optimal cut-off point of serum CTRP12 on one day before discharge for predicting ISR in AMI patients after PCI was 3.89 ng/mL （sensitivity 93.3% and specificity 73.0%）， and the area under the ROC curve （AUC） was 0.849. Conclusions Serum CTRP12 level inone day before discharge has certain predictive value for ISR in AMI patients after PCI. CTRP12 may be a therapeutic target for ISR in AMI patients after PCI.
Youming ZHANG , Junhui GONG , Hongtao ZHU . Relationship between serum CTRP12 level and in⁃stent restenosis in patients with acute myocardial infarction after percutaneous coronary intervention[J]. The Journal of Practical Medicine, 2024 , 40(12) : 1671 -1676 . DOI: 10.3969/j.issn.1006-5725.2024.12.010
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