The Journal of Practical Medicine >

2024 , Vol. 40 >Issue 11: 1597 - 1601

DOI: https://doi.org/10.3969/j.issn.1006-5725.2024.11.022

Reviews

Research progress on the relationship between Wnt signaling pathway and neural tube defects

  • Min HU ,
  • Yi RU ,
  • Liangqi XIE ,
  • Zhi CHAI ,
  • Huijie. FAN
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  • Neurobiology Research Center，Shanxi University of Traditional Chinese Medicine，Key Laboratory of Multiple Sclerosis，Nourishing Qi and Activating Blood，National Administration of Traditional Chinese Medicine，Jinzhong 030619，China

Received date: 2023-10-13

  Online published: 2024-06-13

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Abstract

Neural tube defects are a common neurodevelopmental disease， which can be divided into open and closed types. The main symptoms are anencephaly， encephalocele and cranial spina bifida. The relationship between Wnt signaling and neurogenesis has been a popular area in recent years. The Wnt signaling pathway includes Wnt/β-catenin， planar polar cell pathway and Wnt/Ca2+ pathway， which plays an important role in neural tube development. This article reviews the current state of research on the Wnt signaling pathway and elucidates the role it plays in the process of neural tube closure， providing insights for the development of drugs related to the prevention and treatment of neural tube defects.

Key words： neural tube defects; Wnt/β-catenin pathway; planar cell polarity pathway; Wnt/Ca2+ pathway

Cite this article

Min HU , Yi RU , Liangqi XIE , Zhi CHAI , Huijie. FAN . Research progress on the relationship between Wnt signaling pathway and neural tube defects[J]. The Journal of Practical Medicine, 2024 , 40(11) : 1597 -1601 . DOI: 10.3969/j.issn.1006-5725.2024.11.022

References

1 SALAZAR-REVIAKINA A， SIERRA-BRETóN M， RUMBO J， et al. Characterization of Risk Factors for Neural Tube Defects： A Case-Control Study in Bogota and Cali， Colombia， 2001-2018 ［J］. J Child Neurol， 2021， 36（7）： 509-516. doi:10.1177/0883073820981514
2 KIM T W， PIAO J， KOO S Y， et al. Biphasic Activation of WNT Signaling Facilitates the Derivation of Midbrain Dopamine Neurons from hESCs for Translational Use ［J］. Cell Stem Cell， 2021， 28（2）： 343-355.e5. doi:10.1016/j.stem.2021.01.005
3 MARTIN M， VERMEIREN S， BOSTAILLE N， et al. Engineered Wnt ligands enable blood-brain barrier repair in neurological disorders ［J］. Science， 2022， 375（6582）： eabm4459. doi:10.1126/science.abm4459
4 CLEVERS H， NUSSE R. Wnt/β-catenin signaling and disease ［J］. Cell， 2012， 149（6）： 1192-205. doi:10.1016/j.cell.2012.05.012
5 YU F， YU C， LI F， et al. Wnt/β-catenin signaling in cancers and targeted therapies ［J］. Signal Transduct Target Ther， 2021， 6（1）： 307. doi:10.1038/s41392-021-00701-5
6 CHEN Y， CHEN Z， TANG Y， et al. The involvement of noncanonical Wnt signaling in cancers ［J］. Biomed Pharmacother， 2021， 133： 110946. doi:10.1016/j.biopha.2020.110946
7 LóPEZ-ESCOBAR B， CARO-VEGA J M， VIJAYRAGHAVAN D S， et al. The non-canonical Wnt-PCP pathway shapes the mouse caudal neural plate ［J］. Development， 2018， 145（9）：dev157487.
8 ZHEN H， DENG H， SONG Q， et al. The Wnt/Ca（2+） signaling pathway is essential for the regeneration of GABAergic neurons in planarian Dugesia japonica ［J］. FASEB J， 2020， 34（12）： 16567-16580. doi:10.1096/fj.201903040rr
9 GAO J， LIAO Y， QIU M， et al. Wnt/β-Catenin Signaling in Neural Stem Cell Homeostasis and Neurological Diseases ［J］. Neuroscientist， 2021， 27（1）： 58-72. doi:10.1177/1073858420914509
10 丁芮， 周鹏， 王翔，等. 基于Wnt5a/Ca~（2+）/NFAT信号通路研究小陷胸汤调控Ca~（2+）载量抑制MGC-803细胞侵袭迁移和上皮间质转化作用 ［J］. 中国实验方剂学杂志， 2022， 28（12）： 1-11.
11 WANG H， ZHANG R， WU X， et al. The Wnt Signaling Pathway in Diabetic Nephropathy ［J］. Front Cell Dev Biol， 2021， 9： 701547. doi:10.3389/fcell.2021.701547
12 SUTTON G， KELSH R N， SCHOLPP S. Review： The Role of Wnt/β-Catenin Signalling in Neural Crest Development in Zebrafish ［J］. Front Cell Dev Biol， 2021， 9： 782445. doi:10.3389/fcell.2021.782445
13 GANDHI S， HUTCHINS E J， MARUSZKO K， et al. Bimodal function of chromatin remodeler Hmga1 in neural crest induction and Wnt-dependent emigration ［J］. Elife， 2020， 9：e57779. doi:10.7554/elife.57779
14 李霞， 赵声波， 毕先云， 等. PAX3基因新突变致Ⅰ型Waardenburg综合征家系基因型与表型特征分析 ［J］. 临床耳鼻咽喉头颈外科杂志， 2021， 35（7）： 621-626.
15 赵拴平， 金海， 徐磊，等. 牛PAX3基因结构分析及蛋白功能预测 ［J］. 中国草食动物科学， 2021， 41（5）： 8-11. doi:10.3969/j.issn.2095-3887.2021.05.002
16 PALMER A J， SAVERY D， MASSA V， et al. Genetic interaction of Pax3 mutation and canonical Wnt signaling modulates neural tube defects and neural crest abnormalities ［J］. Genesis， 2021， 59（11）： e23445. doi:10.1002/dvg.23445
17 ZHAO T， MCMAHON M， REYNOLDS K， et al. The role of Lrp6-mediated Wnt/β-catenin signaling in the development and intervention of spinal neural tube defects in mice ［J］. Dis Model Mech， 2022， 15（6）：dmm049517. doi:10.1242/dmm.049517
18 XIANG Y， ZHAO Q， WANG N， et al. Association of Obesity with the Risk of Hyperhomocysteinemia among the Chinese Community Residents： A Prospective Cohort Study in Shanghai， China ［J］. Nutrients， 2021， 13（10）：3648. doi:10.3390/nu13103648
19 PIZZORUSSO T， TOGNINI P. Interplay between Metabolism， Nutrition and Epigenetics in Shaping Brain DNA Methylation， Neural Function and Behavior ［J］. Genes （Basel）， 2020， 11（7）：742. doi:10.3390/genes11070742
20 LIU Y S， GU H， HUANG T C， et al. miR-322 treatment rescues cell apoptosis and neural tube defect formation through silencing NADPH oxidase 4 ［J］. CNS Neurosci Ther， 2020， 26（9）： 902-912. doi:10.1111/cns.13383
21 LI X， ZHOU W， LI X， et al. SOX19b regulates the premature neuronal differentiation of neural stem cells through EZH2-mediated histone methylation in neural tube development of zebrafish ［J］. Stem Cell Res Ther， 2019， 10（1）： 389. doi:10.1186/s13287-019-1495-3
22 WENG S， HUEBNER R J， WALLINGFORD J B. Convergent extension requires adhesion-dependent biomechanical integration of cell crawling and junction contraction ［J］. Cell Rep， 2022， 39（4）： 110666. doi:10.1016/j.celrep.2022.110666
23 BUTLER M T， WALLINGFORD J B. Planar cell polarity in development and disease ［J］. Nat Rev Mol Cell Biol， 2017， 18（6）： 375-388. doi:10.1038/nrm.2017.11
24 SHINDO A. Models of convergent extension during morphogenesis ［J］. Wiley Interdiscip Rev Dev Biol， 2018， 7（1）：e293. doi:10.1002/wdev.293
25 BAILLY E， WALTON A， BORG J P. The planar cell polarity Vangl2 protein： From genetics to cellular and molecular functions ［J］. Semin Cell Dev Biol， 2018， 81： 62-70. doi:10.1016/j.semcdb.2017.10.030
26 GALEA G L， NYCHYK O， MOLE M A， et al. Vangl2 disruption alters the biomechanics of late spinal neurulation leading to spina bifida in mouse embryos ［J］. Dis Model Mech， 2018， 11（3）：dmm032219.
27 LIU Y， DONG L， ZHI X， et al. Single nucleotide polymorphisms of PCP pathway related genes participate in the occurrence and development of neural tube defect ［J］. Mol Genet Genomic Med， 2023， 11（1）： e2094. doi:10.1002/mgg3.2094
28 WANG Y， CHANG H， RATTNER A， et al. Frizzled Receptors in Development and Disease ［J］. Curr Top Dev Biol， 2016， 117： 113-139. doi:10.1016/bs.ctdb.2015.11.028
29 JAMUAR S S， WALSH C A. Somatic mutations in cerebral cortical malformations ［J］. N Engl J Med， 2014， 371（21）： 2038. doi:10.1056/nejmc1411784
30 田甜. 平面细胞极化信号通路基因拷贝数变异和体细胞突变与神经管缺陷 ［D］. 北京：北京大学医学部， 2021.
31 JOSHI B， GAUR H， HUI S P， et al. Celsr family genes are dynamically expressed in embryonic and juvenile zebrafish ［J］. Dev Neurobiol， 2022， 82（2）： 192-213. doi:10.1002/dneu.22868
32 CHEN Z， LEI Y， CAO X， et al. Genetic analysis of Wnt/PCP genes in neural tube defects ［J］. BMC Med Genomics， 2018， 11（1）： 38. doi:10.1186/s12920-018-0355-9
33 BUTLER M T， WALLINGFORD J B. Spatial and temporal analysis of PCP protein dynamics during neural tube closure ［J］. Elife， 2018， 7：e36456. doi:10.7554/elife.36456
34 LIU L， LIU W， SHI Y， et al. DVL mutations identified from human neural tube defects and Dandy-Walker malformation obstruct the Wnt signaling pathway ［J］. J Genet Genomics， 2020， 47（6）： 301-310. doi:10.1016/j.jgg.2020.06.003
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