Objective We tried to investigate the difference of respiratory symptoms， quality of life， blood routine examination and bone metabolism in patients with newly diagnosed chronic obstructive pulmonary disease with and without hypertension. Methods A total of 92 newly diagnosed patients with chronic obstructive pulmonary disease and hypertension treated in our hospital from January 2019 to April 2022 were selected as the observation group， and 92 newly diagnosed patients with COPD without hypertension were selected as the control group. The modified British Medical Research Council Respiratory Questionnaire （mMRC）， Chronic Obstructive Pulmonary Disease Self Assessment Test Questionnaire （CAT）， Global Initiative for Chronic Obstructive Pulmonary Disease （GOLD）， SF-36 scale scores， blood routine examination and bone metabolism indexes were different. Results The rate of mMRC grade ≥ 2 and CAT score of the observation group were significantly higher than those of the control group （P < 0.05）， while the SF-36 score was significantly lower than that of the control group （P < 0.05）. The GOLD grading of the observation group was significantly higher than that of the control group （P < 0.05）. The forced vital capacity （FVC） and the first second expiratory volume （FEV1） in the observation group were significantly lower than those in the control group （P < 0.05）. There was no significant difference between the observation group and the control group in white blood cell count （WBC）， neutrophil count （NEUT） and lymphocyte count （LYM） etc （P > 0.05）. The bone mineral density of the femoral neck and blood calcium in the observation group were significantly lower than those in the control group （P < 0.05）， while the parathyroid hormone （PTH） and osteocalcin （BGP） were significantly higher than those in the control group （P < 0.05）. The levels of C-reactive protein （CRP）， procalcitonin （PCT）， interleukin-6 （IL-6）， IL-4， and IL-10 in the observation group were significantly higher than those in the control group （P < 0.05）. The hypertension grade in the observation group was positively correlated with mMRC grade， CAT score and GOLD grade （r_s = 0.455， 0.302 and 0.501， P < 0.05）， but negatively correlated with FVC and FEV1 （r_s = -0.311 and -0.334， P < 0.05）. Conclusion The newly diagnosed patients with chronic obstructive pulmonary disease and hypertension have severe respiratory symptoms， poor quality of life， and an increased risk of osteoporosis， and the patient's blood pressure is related to the degree of respiratory symptoms.