The Journal of Practical Medicine >

2024 , Vol. 40 >Issue 11: 1488 - 1493

DOI: https://doi.org/10.3969/j.issn.1006-5725.2024.11.004

Feature Reports：Parkinson's disease

Effects of transcranial direct current stimulation on sleep disorders in Parkinson′s disease： a randomized， single⁃blind controlled trial

  • Jianjun LU ,
  • Yu HAN ,
  • Qiumin YU ,
  • Jiawen LIU ,
  • Minghua ZHU ,
  • Jinzhi LIN ,
  • Yang ZHANG ,
  • Yong ZHANG ,
  • Jinjian. WANG
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  • *.Department of Neurosurgery，the Guangdong Second People's Hospital，Guangzhou 510317，China

Received date: 2023-12-05

  Online published: 2024-06-13

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Abstract

Objective To investigate the efficacy of transcranial direct current stimulation （tDCS） on sleep disorder in patients with Parkinson's disease （PD）. Methods From July 2021 to July 2023， patients with PD and sleep disorders in the Department of Neurosurgery of the Second People's Hospital of Guangdong Province were selected. The enrolled patients were divided into sham stimulation group （n = 28 ） and true stimulation group （tDCS） （n = 29） according to the inclusion and exclusion criteria. MDS-UPDRS， PDSS and other rating scales were used to evaluate the patients. Before and after tDCS treatment， MS-11 was used for intelligent sleep monitoring. The baseline and improvement of sleep disorders in the two groups before and after treatment were analyzed. Results Before tDCS treatment， there was no significant difference in general conditions and scale scores between the two groups （P > 0.05）. There was no significant difference in polysomnographic monitoring results between the two groups before treatment （P > 0.05）. Compared with pre-treatment， there was no significant difference in sleep monitoring results in the sham stimulation group （P > 0.05）， while the sleep duration and sleep efficiency significantly increased， the nighttime awakening duration， nighttime awakening frequency， MDS-UPDRS-III score， and LEDD dose significantly decreased in the true stimulation group， with statistical significance （P < 0.05）. Conclusion Pharmacological treatment combined with tDCS treatment is effective for sleep disorders and motor function in patients with PD， which could increase the sleep duration and sleep efficiency of PD patients with sleep disorders to a certain extent， reduce the nighttime awakening duration and frequency， thereby improving the fatigue symptoms during the daytime， and improving the efficacy of conventional pharmacological treatment for PD.

Key words： Parkinson's disease; sleep disorders; transcranial direct current stimulation; intelligent sleep monitoring

Cite this article

Jianjun LU , Yu HAN , Qiumin YU , Jiawen LIU , Minghua ZHU , Jinzhi LIN , Yang ZHANG , Yong ZHANG , Jinjian. WANG . Effects of transcranial direct current stimulation on sleep disorders in Parkinson′s disease： a randomized， single⁃blind controlled trial[J]. The Journal of Practical Medicine, 2024 , 40(11) : 1488 -1493 . DOI: 10.3969/j.issn.1006-5725.2024.11.004

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