The Journal of Practical Medicine >
Clinical efficacy of simple surgery and surgery combined with glucocorticoids in the treatment of mass type granulomatous mastitis
Received date: 2023-12-09
Online published: 2024-05-15
Objective To compare and analyze the clinical efficacy， recurrence rate， and breast appearance evaluation of simple surgery and surgery combined with glucocorticoids in the treatment of mass type granulomatous mastitis. Methods This study retrospectively analyzed 106 patients with nodular granulomatous mastitis who visited the Department of Breast Surgery at Yichang Central People's Hospital from January 2017 to January 2022 as the study subjects. According to the different treatment methods during the visit， patients were divided into Group A with simple surgical treatment （n = 67） and Group B with surgery combined with glucocorticoid treatment （n = 39）. The general information and clinical indicators of the two groups of patients were observed and compared. Obtain patient clinical efficacy， time to clinical cure （TTCR）， recurrence rate within one year， and breast appearance evaluation through follow?up. Results The prognosis of the follow?up patients after treatment showed that Group B patients had better clinical cure rate and one?year recurrence rate than the simple surgery group （P < 0.05）. Moreover， the difference in breast appearance evaluation between the two groups was statistically significant， with Group B patients having a significantly higher rate of excellent appearance （88.06%） than Group A （92.31%）. According to statistics， only 5.13% of patients in Group B experienced gastrointestinal reactions within one year after taking hormone therapy. Conclusions The combination of surgery and glucocorticoids in the treatment of mass type GM can effectively improve the overall clinical treatment effect of patients， reduce the short?term recurrence rate， and have a significant effect on ensuring the integrity of breast appearance. At the same time， low?dose oral steroid drugs have fewer adverse reactions and high safety.
Tianyue CUI , Liquan OUYANG , Shengchu. ZHANG . Clinical efficacy of simple surgery and surgery combined with glucocorticoids in the treatment of mass type granulomatous mastitis[J]. The Journal of Practical Medicine, 2024 , 40(9) : 1268 -1274 . DOI: 10.3969/j.issn.1006-5725.2024.09.015
| 1 | YUAN Q Q， XIAO S Y， FAROUK O， et al. Management of granulomatous lobular mastitis： an international multidisciplinary consensus （2021 edition） ［J］. Mil Med Res， 2022，9（1）：20. |
| 2 | 张超杰，胡金辉，赵希. 肉芽肿性小叶性乳腺炎诊治湖南专家共识（2021版）［J］. 中国普通外科杂志，2021，30（11）：1257-1273. |
| 3 | 周飞，刘璐，余之刚. 非哺乳期乳腺炎诊治专家共识［J］. 中国实用外科杂志，2016，36（7）： 755-758. |
| 4 | 兰柳逸，冯秦玉，周瑞，等. 肉芽肿性小叶性乳腺炎研究进展［J］. 医学新知，2021，31（3）：186-196. doi:10.12173/j.issn.1004-5511.202105039 |
| 5 | YIN Y， LIU X， MENG Q， et al. Idiopathic Granulomatous Mastitis： Etiology， Clinical Manifestation， Diagnosis and Treatment［J］. J Invest Surg， 2022，35（3）：709-720. doi:10.1080/08941939.2021.1894516 |
| 6 | ZHOU R， LAN L， ZHENG L， et al. Diagnosis and treatment of patients with granulomatous lobular mastitis （in Chinese）［J］. Chin J General Surg， 2021，36（2）：118-121. |
| 7 | BELLAVIA M， DAMIANO G， PALUMBO V D， et al. Granulomatous mastitis during chronic antidepressant therapy： is it possible a conservative therapeutic approach？［J］. J Breast Cancer， 2012，15（3）：371-372. doi:10.4048/jbc.2012.15.3.371 |
| 8 | FAROUK O， ABDELKHALEK M， ABDALLAH A， et al. Rifampicin for idiopathic granulomatous lobular mastitis： a promising alternative for treatment［J］. World J Surg，2017，41（5）：1313-1321. doi:10.1007/s00268-016-3857-7 |
| 9 | YAGHAN R， HAMOURI S， AYOUB N M， et al. A proposal of a clinically based classification for idiopathic granulomatous mastitis［J］. Asian Pac J Cancer Prev， 2019，20（3）：929-934. doi:10.31557/apjcp.2019.20.3.929 |
| 10 | 邵牧民，毕嘉欣. 肉芽肿性小叶性乳腺炎病理诊断路径［J］. 临床与实验病理学杂志， 2023，39（9）：1042-1048. |
| 11 | 程涓，丁华野，杜玉堂，等. 肉芽肿性小叶性乳腺炎伴发乳腺导管扩张症及结节性红斑4例临床病理分析［J］. 诊断病理学杂志， 2014，21（8）：488-490，494. doi:10.3969/j.issn.1007-8096.2014.08.008 |
| 12 | 陈铃，刘桂连，张建兴，等. 彩超对不同分型肉芽肿性小叶性乳腺炎的诊断价值［J］. 中国超声医学杂志， 2017，33（3）：213-216. doi:10.3969/j.issn.1002-0101.2017.03.008 |
| 13 | 严松莉，唐旭平，沈纪松，等. 肉芽肿性乳腺炎的声像图特征及超声分型［J］. 临床超声医学杂志， 2007，9（6）：344-346. doi:10.3969/j.issn.1008-6978.2007.06.007 |
| 14 | 韩思佳，金晓明，刘臻，等. 类固醇激素治疗后手术切除与直接扩大切除治疗肉芽肿性小叶性乳腺炎的对比分析［J］. 中华乳腺病杂志（电子版）， 2018，12（6）：373-375. |
| 15 | 颜芬，李杰，丁伟山，等. 肉芽肿性小叶性乳腺炎超声表现及与临床病理对照分析［J］. 中国超声医学杂志， 2017，33（1）：79-81. doi:10.3969/j.issn.1002-0101.2017.01.028 |
| 16 | 中华预防医学会妇女保健分会乳腺保健与乳腺疾病防治学组. 非哺乳期乳腺炎诊治专家共识［J］. 中国实用外科杂志， 2016， 36（7）：755-758. |
| 17 | 张玉娟，袁惠玲，邓丁梅，等. 不同治疗方案对肉芽肿性乳腺炎患者炎症状态及生活质量的影响［J］. 基层医学论坛， 2023，27（22）：4-7. |
| 18 | 夏婷婷，邵成杰，史家欣. 低剂量短疗程糖皮质激素对社区获得性肺炎的影响［J］. 实用医学杂志，2021，37（19）：2563?2564，2568. |
| 19 | 邹素文，朱彩霞，张安秦. 肉芽肿性乳腺炎的激素治疗进展［J］.实用医学杂志， 2022，38（13）：1711-1714. doi:10.3969/j.issn.1006-5725.2022.13.028 |
| 20 | AKBULUT S， YILMAZ D， BAKIR S. Methotrexate in the management of idiopathic granulomatous mastitis：Review of 108 published cases and report of four cases［J］. Breast J，2011，17 （6）：661?668. doi:10.1111/j.1524-4741.2011.01162.x |
| 21 | AGHAJANZADEH M， HASSANZADEH R， ALIZADEH SEFAT S， et al. Granulomatous mastitis： Presentations， diagnosis， treatment and outcome in 206 patients from the north of Iran［J］. Breast， 2015，24（4）：456-460. doi:10.1016/j.breast.2015.04.003 |
| 22 | 白吉明，张勃，杨强，等. 肉芽肿性乳腺炎19例诊治分析［J］. 感染、炎症、修复， 2018，19（2）：110-111，129. |
| 23 | SHOJAEE L， RAHMANI N， MORADI S，et al. Idiopathic granulomatous mastitis：challenges of treatment in iranian women［J］.BMC Surg， 2021，21（1）：206. doi:10.1186/s12893-021-01210-6 |
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