Objective To explore the factors influencing the short?term adverse clinical outcome in patients hospitalized with grade 2/3 cirrhosis ascites. Methods 82 patients with grade 2/3 cirrhosis ascites in Kunming Third People's Hospital from December 2021 to February 2023 were used as research objects. Demographic data and first clinical data were collected. The clinical outcomes of the patients within 90 days after admission were followed up. Influencing factors of adverse clinical outcome were investigated by single factor screening and binary logistic regression analysis， including hospitalization over 28 days， unplanned readmission within 28 days， and death within 90 days （including death within 28 days）. Finally， the diagnostic efficacy of the influencing factors were judged by ROC curve. Results （1）MELD?Na score （OR = 1.087， 95%CI： 1.006 ~ 1.175） and GGT （OR = 1.004， 95%CI： 1.002 ~ 1.007） were independent risk factors for hospitalization longer then 28 days， unplanned readmission within 28 days of admission and death within 28 days， respectively， all P < 0.05. BUN was an independent risk factor for all three conditions， with an OR of 1.111 （95% CI： 1.005 ~ 1.227）， 1.115 （95%CI： 1.003 ~ 1.214） and 1.208 （95%CI： 1.057 ~ 1.382）， all P < 0.05. （2）low serum chloride （OR = 0.875， 95%CI： 0.802 ~ 0.954） and low total CO₂ （OR = 0.821， 95%CI： 0.690 ~ 0.976） were independent riak factors for death within 90 days， all P < 0.05. （3）The area under ROC curve of BUN combined with GGT predicted death within 28 days was 0.891； The area under curve of serum chloride combined with total CO₂ predicted death within 90 days was 0.821， P < 0.05. Conclusion BUN combined with GGT had better predictive value for death within 28 days， serum chloride combined with total CO₂ had better predictive value for death within 90 days.