The Journal of Practical Medicine >
MAPK improves intestional obstruction in pregnancy through inhibiting TLR4/Myd88/NF⁃κB pathway
Received date: 2023-04-24
Online published: 2024-04-19
Objective To investigate the effect of MAPK on intestinal obstruction during pregnancy. Methods A total of 105 SPF Wistar rats （female = 70 and male = 35） were selected. After placing all the rats in the same cage， 33 female rats were pregnant， and 8 rats were assigned to the control group and the other 25 rats were used to established bowel obstruction model. A total of 24 rats were successfully modelled， which were divided into model group（n = 8）， up-regulation group（n = 8）， and down-regulation group（n = 8）. Results Compared with the model group， MAPK expression， VIP， GAS， TNF-α， IL-6 levels， TLR4， Myd88， NF-κBmRNA were increased and MOT， IL-4， IL-10 levels were decreased in up-regulation group； MAPK expression， VIP， GAS， TNF-α， IL-6 levels， TLR4， Myd88， NF-κB mRNA were decreased and MOT， IL-4， IL-10 levels were increased in down-regulation group （P < 0.05）. Conclusion MAPK down-regulation reduced inflammatory response and improved bowel obstruction in pregnancy， and the mechanism may be related to the inhibition of TLR4/Myd88/NF-κB pathway.
Fei GAO , Jing LI , Hongjian. LI . MAPK improves intestional obstruction in pregnancy through inhibiting TLR4/Myd88/NF⁃κB pathway[J]. The Journal of Practical Medicine, 2024 , 40(8) : 1095 -1100 . DOI: 10.3969/j.issn.1006-5725.2024.08.013
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