The Journal of Practical Medicine >

2024 , Vol. 40 >Issue 7: 924 - 929

DOI: https://doi.org/10.3969/j.issn.1006-5725.2024.07.008

Feature Reports：Reproductive medicine

Role of complement C3 in early predicting pregnancy outcomes of frozen⁃thawed embryo transfer

  • Zhixia TANG ,
  • Shuangying MA ,
  • Ying ZHAGN ,
  • Jiajia SHENG ,
  • Juan LI ,
  • Jingjing HE ,
  • Henghua XUAN ,
  • Mingyun. HONG
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  • Centre for Reproductive Medicine，Anhui Maternal and Child Health Hospital，Anhui Medical University，Hefei 230001，China

Received date: 2023-08-10

  Online published: 2024-04-08

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Abstract

Objective To investigate the role of complement C3 in early predicting pregnancy outcomes of frozen-thawed embryo transfer （F-ET）. Methods A total of 378 F-ET cycles were prospectively collected and divided into group A （complement C3 ≤ 1.05， 120 cycles） and group B （complement C3 > 1.05， 258 cycles） based on the best cutoff value of complement C3 for predicting F-ET pregnancy outcomes. The outcomes of the two groups were compared， and the best cutoff value of complement C3 for predicting F-ET spontaneous abortion was analyzed in group B. Results Age was a risk factor for successful F-ET pregnancy （P < 0.05）， and complement C3 and embryo type were protective factors for successful F-ET pregnancy （P < 0.05）. The area under the receiver-operating characteristic curve （ROC） of complement C3 for predicting F-ET pregnancy outcome was 0.702， and the best cutoff value was 1.05 g/L， with a clinical pregnancy sensitivity of 87.60% and a specificity of 52.00%. The clinical pregnancy rate and embryo implantation rate in group B were both significantly higher than those in group A （67.05% vs. 52.75%， P < 0.05）. The best cutoff value of complement C3 for predicting spontaneous abortion after F-ET was 1.32 g/L， with an area under the ROC curve of 0.760， a sensitivity of 69.00%， and a specificity of 81.20%. Conclusions Complement C3 is of significance in the early prediction of F-ET pregnancy outcome. When complement C3 exceeds the level of 1.32 g/L， it may lead to an increase in the rate of spontaneous abortion.

Key words： frozen embryo transfer; clinical pregnancy rate; complement C3

Cite this article

Zhixia TANG , Shuangying MA , Ying ZHAGN , Jiajia SHENG , Juan LI , Jingjing HE , Henghua XUAN , Mingyun. HONG . Role of complement C3 in early predicting pregnancy outcomes of frozen⁃thawed embryo transfer[J]. The Journal of Practical Medicine, 2024 , 40(7) : 924 -929 . DOI: 10.3969/j.issn.1006-5725.2024.07.008

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