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Research progress of the endoplasmic reticulum⁃mitochondrial interactions in post⁃stroke cognitive impairment
Received date: 2023-10-22
Online published: 2024-04-08
Post-stroke cognitive impairment （PSCI），refers to a range of clinical syndromes of cognitive impairment caused by stroke. Although its specific pathogenesis is still unclear，many studies have confirmed that endoplasmic reticulum-mitochondria interaction has become a key hub for intracellular signal transduction and substance metabolism， and its regulation of various biological processes，such as Ca2+ balance，lipid metabolism，mitochondrial dynamics，autophagy， and neuroinflammation，is closely related to the development of PSCI. Therefore，in this paper，we will review the various functions of endoplasmic reticulum-mitochondrial interactions and explore their specific roles in PSCI，in order to discover new therapeutic targets and provide new theoretical basis and references for the development of PSCI-targeted drugs in the future.
Lulu CHEN , Meng LUO , Kaiqi SU , Jing GAO , Xiaodong. FENG . Research progress of the endoplasmic reticulum⁃mitochondrial interactions in post⁃stroke cognitive impairment[J]. The Journal of Practical Medicine, 2024 , 40(7) : 1023 -1028 . DOI: 10.3969/j.issn.1006-5725.2024.07.025
| 1 | 汪凯，董强. 卒中后认知障碍管理专家共识［J］. 中国卒中杂志， 2021，16（4）：376-389. |
| 2 | ROST N S， BRODTMANN A， PASE M P， et al. Post-Stroke Cognitive Impairment and Dementia［J］. Circ Res， 2022，130（8）：1252-1271. doi:10.1161/circresaha.122.319951 |
| 3 | MIJAJLOVI? M D， PAVLOVI? A， BRAININ M， et al. Post-stroke dementia - a comprehensive review［J］. BMC Med， 2017，15（1）：11. doi:10.1186/s12916-017-0779-7 |
| 4 | NUNNARI J， SUOMALAINEN A. Mitochondria： in sickness and in health［J］. Cell， 2012，148（6）：1145-1159. doi:10.1016/j.cell.2012.02.035 |
| 5 | ZHANG P， KONJA D， ZHANG Y， et al. Communications between Mitochondria and Endoplasmic Reticulum in the Regulation of Metabolic Homeostasis［J］. Cells， 2021，10（9）：2195. doi:10.3390/cells10092195 |
| 6 | ROWLAND A A， VOELTZ G K. Endoplasmic reticulum-mitochondria contacts： function of the junction［J］. Nat Rev Mol Cell Biol， 2012，13（10）：607-625. doi:10.1038/nrm3440 |
| 7 | ERPAPAZOGLOU Z， MOUTON-LIGER F， CORTI O. From dysfunctional endoplasmic reticulum-mitochondria coupling to neurodegeneration［J］. Neurochem Int， 2017，109：171-183. doi:10.1016/j.neuint.2017.03.021 |
| 8 | LIU J， YANG J. Mitochondria-associated membranes： A hub for neurodegenerative diseases［J］. Biomed Pharmacother， 2022，149：112890. doi:10.1016/j.biopha.2022.112890 |
| 9 | SILVA BSC， DIGIOVANNI L， KUMAR R， et al. Maintaining social contacts： The physiological relevance of organelle interactions［J］. Biochim Biophys Acta Mol Cell Res， 2020，1867（11）：118800. doi:10.1016/j.bbamcr.2020.118800 |
| 10 | COPELAND D E， DALTON A J. An association between mitochondria and the endoplasmic reticulum in cells of the pseudobranch gland of a teleost［J］. J Biophys Biochem Cytol， 1959，5（3）：393-396. doi:10.1083/jcb.5.3.393 |
| 11 | VANCE J E. Phospholipid synthesis in a membrane fraction associated with mitochondria［J］. J Biol Chem， 1990，265（13）：7248-7256. doi:10.1016/s0021-9258(19)39106-9 |
| 12 | POSTON C N， KRISHNAN S C， BAZEMORE-WALKER C R. In-depth proteomic analysis of mammalian mitochondria-associated membranes （MAM）［J］. J Proteomics， 2013，79：219-230. doi:10.1016/j.jprot.2012.12.018 |
| 13 | MAO H， CHEN W， CHEN L， et al. Potential role of mitochondria-associated endoplasmic reticulum membrane proteins in diseases［J］. Biochem Pharmacol， 2022，199：115011. doi:10.1016/j.bcp.2022.115011 |
| 14 | LUDHIADCH A， SHARMA R， MURIKI A， et al. Role of Calcium Homeostasis in Ischemic Stroke： A Review［J］. CNS Neurol Disord Drug Targets， 2022，21（1）：52-61. doi:10.2174/1871527320666210212141232 |
| 15 | ZHANG Y， MAO X， LIN R， et al. Electroacupuncture ameliorates cognitive impairment through inhibition of Ca2+-mediated neurotoxicity in a rat model of cerebral ischaemia-reperfusion injury［J］. Acupunct Med， 2018，36（6）：401-407. doi:10.1136/acupmed-2016-011353 |
| 16 | HUTCHINS B I， LI L， KALIL K. Wnt-induced calcium signaling mediates axon growth and guidance in the developing corpus callosum［J］. Sci Signal， 2012，5（206）：pt1. doi:10.1126/scisignal.2002523 |
| 17 | DE RIDDER I， KERKHOFS M， LEMOS F O， et al. The ER-mitochondria interface， where Ca2+ and cell death meet［J］. Cell Calcium， 2023，112：102743. doi:10.1016/j.ceca.2023.102743 |
| 18 | CHANG Y， WANG C， ZHU J， et al. SIRT3 ameliorates diabetes-associated cognitive dysfunction via regulating mitochondria-associated ER membranes［J］. J Transl Med， 2023，21（1）：494. doi:10.1186/s12967-023-04246-9 |
| 19 | SONG L L， QU Y Q， TANG Y P， et al. Hyperoside alleviates toxicity of β-amyloid via endoplasmic reticulum-mitochondrial calcium signal transduction cascade in APP/PS1 double transgenic Alzheimer's disease mice［J］. Redox Biol， 2023，61：102637. doi:10.1016/j.redox.2023.102637 |
| 20 | YOON J H， SEO Y， JO Y S， et al. Brain lipidomics： From functional landscape to clinical significance［J］. Sci Adv， 2022，8（37）：eadc9317. doi:10.1126/sciadv.adc9317 |
| 21 | SABOGAL-GUáQUETA A M， VILLAMIL-ORTIZ J G， ARIAS-LONDO?O J D， et al. Inverse Phosphatidylcholine/Phosphatidylinositol Levels as Peripheral Biomarkers and Phosphatidylcholine/Lysophosphatidylethanolamine-Phosphatidylserine as Hippocampal Indicator of Postischemic Cognitive Impairment in Rats［J］. Front Neurosci， 2018，12：989. doi:10.3389/fnins.2018.00989 |
| 22 | LIU L W， YUE H Y， ZOU J， et al. Comprehensive metabolomics and lipidomics profiling uncovering neuroprotective effects of Ginkgo biloba L. leaf extract on Alzheimer's disease［J］. Front Pharmacol， 2022，13：1076960. doi:10.3389/fphar.2022.1076960 |
| 23 | YANG Z， WANG H， EDWARDS D， et al. Association of blood lipids， atherosclerosis and statin use with dementia and cognitive impairment after stroke： A systematic review and meta-analysis［J］. Ageing Res Rev， 2020，57：100962. doi:10.1016/j.arr.2019.100962 |
| 24 | VOELKER D R. Reconstitution of phosphatidylserine import into rat liver mitochondria ［J］. J Biol Chem， 1989， 264（14）： 8019-8025. doi:10.1016/s0021-9258(18)83144-1 |
| 25 | HUTTUNEN H J， HAVAS D， PEACH C， et al. The acyl-coenzyme A： cholesterol acyltransferase inhibitor CI-1011 reverses diffuse brain amyloid pathology in aged amyloid precursor protein transgenic mice［J］. J Neuropathol Exp Neurol， 2010，69（8）：777-788. doi:10.1097/nen.0b013e3181e77ed9 |
| 26 | BRYLEVA E Y， ROGERS M A， CHANG C C， et al. ACAT1 gene ablation increases 24（S）-hydroxycholesterol content in the brain and ameliorates amyloid pathology in mice with AD［J］. Proc Natl Acad Sci U S A， 2010，107（7）：3081-3086. doi:10.1073/pnas.0913828107 |
| 27 | YANG J L， MUKDA S， CHEN S D. Diverse roles of mitochondria in ischemic stroke［J］. Redox Biol， 2018，16：263-275. doi:10.1016/j.redox.2018.03.002 |
| 28 | LAI Y， LIN P， CHEN M， et al. Restoration of L-OPA1 alleviates acute ischemic stroke injury in rats via inhibiting neuronal apoptosis and preserving mitochondrial function［J］. Redox Biol， 2020，34：101503. doi:10.1016/j.redox.2020.101503 |
| 29 | KANDIMALLA R， MANCZAK M， FRY D， et al. Correction to： Reduced dynamin-related protein 1 protects against phosphorylated Tau-induced mitochondrial dysfunction and synaptic damage in Alzheimer's disease［J］. Hum Mol Genet， 2023，32（8）：1410-1411. doi:10.1093/hmg/ddac305 |
| 30 | ZHANG Y， RUI T， LUO C， LI Q. Mdivi-1 alleviates brain damage and synaptic dysfunction after intracerebral hemorrhage in mice［J］. Exp Brain Res， 2021，239（5）：1581-1593. doi:10.1007/s00221-021-06089-6 |
| 31 | CHENG Y， BUCHAN M， VITANOVA K， et al. Neuroprotective actions of leptin facilitated through balancing mitochondrial morphology and improving mitochondrial function［J］. J Neurochem， 2020，155（2）：191-206. doi:10.1111/jnc.15003 |
| 32 | FRIEDMAN J R， LACKNER L L， WEST M， et al. ER tubules mark sites of mitochondrial division［J］. Science， 2011，334（6054）：358-362. doi:10.1126/science.1207385 |
| 33 | OUYANG M， ZHANG Q， SHU J， et al. Capsaicin Ameliorates the Loosening of Mitochondria-Associated Endoplasmic Reticulum Membranes and Improves Cognitive Function in Rats With Chronic Cerebral Hypoperfusion［J］. Front Cell Neurosci， 2022，16：822702. doi:10.3389/fncel.2022.822702 |
| 34 | JIANG S， NANDY P， WANG W， et al. Mfn2 ablation causes an oxidative stress response and eventual neuronal death in the hippocampus and cortex［J］. Mol Neurodegener， 2018，13（1）：5. doi:10.1096/fasebj.31.1_supplement.659.7 |
| 35 | LIU B， GAO J M， LI F， et al. Gastrodin Attenuates Bilateral Common Carotid Artery Occlusion-Induced Cognitive Deficits via Regulating Aβ-Related Proteins and Reducing Autophagy and Apoptosis in Rats［J］. Front Pharmacol， 2018，9：405. doi:10.3389/fphar.2018.00405 |
| 36 | SHENG R， LIU X Q， ZHANG L S， et al. Autophagy regulates endoplasmic reticulum stress in ischemic preconditioning［J］. Autophagy， 2012，8（3）：310-325. doi:10.4161/auto.18673 |
| 37 | HAMASAKI M， FURUTA N， MATSUDA A， et al. Autophagosomes form at ER-mitochondria contact sites［J］. Nature， 2013，495（7441）：389-393. doi:10.1038/nature11910 |
| 38 | CHEN L， XIA Y F， SHEN S F， et al. Syntaxin 17 inhibits ischemic neuronal injury by resuming autophagy flux and ameliorating endoplasmic reticulum stress［J］. Free Radic Biol Med， 2020，160：319-333. doi:10.1016/j.freeradbiomed.2020.08.010 |
| 39 | 吴静，聂祖琼，尹琬凌. miR-499通过Drp1介导线粒体自噬保护缺氧/复氧心肌细胞［J］.实用医学杂志， 2023，39（17）：2196-2203. doi:10.3969/j.issn.1006-5725.2023.17.008 |
| 40 | ZHAO Z， XIE L， SHI J， et al. Neuroprotective Effect of Zishen Huoxue Decoction treatment on Vascular Dementia by activating PINK1/Parkin mediated Mitophagy in the Hippocampal CA1 Region［J］. J Ethnopharmacol， 2023，319（Pt 1）：117172. doi:10.1016/j.jep.2023.117172 |
| 41 | WANG H， ZHANG S， XIE L， et al. Neuroinflammation and peripheral immunity： Focus on ischemic stroke［J］. Int Immunopharmacol， 2023，120：110332. doi:10.1016/j.intimp.2023.110332 |
| 42 | 陈虹茹，何川，黄重生，等. 电针联合重复经颅磁刺激对D-半乳糖诱导的阿尔茨海默病样模型大鼠学习记忆能力及神经炎症的影响［J］. 实用医学杂志， 2021，37（12）：1534-1538. |
| 43 | LI Y Q， CHEN J X， LI Q W， et al. Targeting NLRP3 inflammasome improved the neurogenesis and post-stroke cognition in a mouse model of photothrombotic stroke［J］. Neuroreport， 2020，31（11）：806-813. doi:10.1097/wnr.0000000000001489 |
| 44 | WANG W X， PRAJAPATI P， NELSON P T， et al. The Mitochondria-Associated ER Membranes Are Novel Subcellular Locations Enriched for Inflammatory-Responsive MicroRNAs［J］. Mol Neurobiol， 2020，57（7）：2996-3013. doi:10.1007/s12035-020-01937-y |
| 45 | SHA R， ZHANG B， HAN X， et al. Electroacupuncture Alleviates Ischemic Brain Injury by Inhibiting the miR-223/NLRP3 Pathway［J］. Med Sci Monit， 2019，25：4723-4733. doi:10.12659/msm.917213 |
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