The Journal of Practical Medicine >

2024 , Vol. 40 >Issue 6: 870 - 876

DOI: https://doi.org/10.3969/j.issn.1006-5725.2024.06.024

Reviews

Research progress of exosomes in distant metastasis and drug resistance of gastric cancer

  • Shu CHEN ,
  • Jinglei ZHANG ,
  • Kang RONG ,
  • Nan ZHANG ,
  • Weiyi SUN
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  • *.He′nan University of Chinese Medicine，Zhengzhou 450046，China

Received date: 2023-10-27

  Online published: 2024-04-08

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Abstract

Gastric cancer （GC） is one of the most common tumors and the fourth leading cause of cancer-related death worldwide.Due to the lack of specific signs in early GC， most cases are diagnosed at an advanced stage， often accompanied by infiltration and distant metastasis. Although chemotherapy is the most commonly used treatment for gastric cancer， due to the emergence of drug resistance， many patients will still relapse after chemotherapy， resulting in poor prognosis.Exosome （EXOs） in the Tumor micro environment （TME） can participate in intercellular communication and play an important role in GC distant metastasis and drug resistance. At present， the detailed mechanism of GC distant metastasis and drug resistance is still unclear. Identifying the exosome-induced mechanism involved in GC distant metastasis and drug resistance can help us find more reliable treatment methods for GC metastasis and drug resistance.This article reviews the mechanism of exosome in GC distant metastasis and drug resistance， in order to provide help for the diagnosis， treatment and research of GC.

Key words： gastric cancer; exosomes; metastasis; drug resistance; chemotherapy

Cite this article

Shu CHEN , Jinglei ZHANG , Kang RONG , Nan ZHANG , Weiyi SUN . Research progress of exosomes in distant metastasis and drug resistance of gastric cancer[J]. The Journal of Practical Medicine, 2024 , 40(6) : 870 -876 . DOI: 10.3969/j.issn.1006-5725.2024.06.024

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