The Journal of Practical Medicine >
The association between vitamin intake and the progression of metabolic dysfunction⁃associated fatty liver disease
Received date: 2023-12-28
Online published: 2024-04-08
Objective There is a Few studies explored the association between vitamin intake and metabolic dysfunction?associated fatty liver disease （MAFLD）， while the existing results were still contradictory. This study aimed to investigate the association between dietary vitamins and all?cause mortality as well as fibrosis risk in patients with MAFLD. Methods The data were extracted from the third National Health and Nutrition Examination Surveys 1988-1994. Dietary vitamins was assessed using a 24 h diet recall， including vitamin A， vitamin B6， vitamin B12， vitamin C， vitamin D， thiamin， riboflavin， folic acid and α?tocopherol. The non?alcoholic fatty liver disease fibrosis score （NFS） < -1.455 was considered as non?advanced fibrosis， while NFS ≥ -1.455 was considered as advanced fibrosis. Results A total of 3844 MAFLD participants were included in this study. The median time of follow?up was 310 months. 1739 participants （45.3%） were deceased during the follow?up. The intake of thiamin， riboflavin， α?tocopherol， VB6， and VB12 were significantly higher in patients with NFS?determined non?advanced fibrosis （P < 0.05）. After adjusting， a significantly lower risk of fibrosis was found in patients with the highest quartile （> 11.5 mg/d） of α?tocopherol intake compared to the lowest intake group （P = 0.031）. Compared to the lowest quartile group， the risk of mortality was reduced by 0.34 folds in the group consuming the highest quartile amount （> 130 mg/d） of VC （HRs： 0.66， 95% CI： 0.51 ~ 0.85， P = 0.001）. Conclusions More α?tocopherol intake reduced fibrosis grade in MAFLD patients. VC intake may reduce all?cause mortality in patients with MAFLD.
Renling YAO , Yixuan ZHU , Rui HUANG , Jie LI . The association between vitamin intake and the progression of metabolic dysfunction⁃associated fatty liver disease[J]. The Journal of Practical Medicine, 2024 , 40(6) : 820 -826 . DOI: 10.3969/j.issn.1006-5725.2024.06.015
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