The Journal of Practical Medicine >
The effect of Xinmailong injection on microcirculation in patients with septic shock
Received date: 2023-07-28
Online published: 2024-03-26
Objective To observe the effect of Xinmailong injection on microcirculation in patients with septic shock， so as to understand the application effect and value of Xinmailong injection in patients with septic shock. Methods A total of 82 patients with septic shock treated in the intensive care unit of our hospital were selected as the research objects and randomly divided into two groups. 41 patients in the control group were treated with conventional septic shock cluster therapy， and 41 patients in the treatment group were treated with Xinmailong injection on the basis of cluster therapy in the control group. Then hemodynamic parameters （HR， CVP， CO， MAP， SVR）， hemorheology （whole blood reducing viscosity， hematocrit， fibrinogen， platelet aggregation rate）， microcirculation perfusion indexes （oxygenation index， blood lactate level， SCVO2， Pcv-aCO2） and 28-day survival rate were detected and compared between the two groups before and after treatment. Results Before treatment， there were no significant differences in hemodynamic parameters， blood rheology and microcirculation perfusion indexes between the two groups （P > 0.05）. After treatment， the above test results of the two groups were significantly improved， and the test results of the treatment group were significantly better than those of the control group， and the 28-day survival rate was also better than that of the control group. The differences were statistically significant （P < 0.05）. Conclusion Xinmailong injection can significantly improve the hemodynamic parameters， blood rheology and microcirculation perfusion indexes， and improve the 28-day survival rate of patients with sepsis. It has a positive clinical effect in the treatment of septic shock patients.
Key words： sepsis; Xinmailong injection; microcirculation; survival rates
Guangping WU , Xin YIN , Jianzhuo HE , Liheng. GUO . The effect of Xinmailong injection on microcirculation in patients with septic shock[J]. The Journal of Practical Medicine, 2024 , 40(5) : 627 -631 . DOI: 10.3969/j.issn.1006-5725.2024.05.007
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