The Journal of Practical Medicine >
The latest developments in nutritional therapy pathways for patients in critical condition
Received date: 2023-10-20
Online published: 2024-03-08
In the ICU, nutritional status is intimately related to the prognosis of critically ill patients and cannot be neglected; nonetheless, between 38% ~ 78% of critically ill patients are malnourished. Individualized nutritional monitoring and therapy is recommended for critically ill patients to improve prognosis. Nutritional treatment includes enteral and parenteral nutrition. Enteral nutrition can be provided by prepyloric feeding through a nasogastric tube, which is simple and generally applicable, or by retropyloric feeding through a nasojejunal tube, which can reduce the risk of reflux aspiration. Parenteral feeding can be administered by creating peripheral venous access for convenient administration or central venous access for the delivery of nutritional solutions with high osmotic pressure. In addition to the patient's condition, the choice of nutrition route should take into account the initiation time, ability to meet nutritional needs, and potential feeding related complications. Current guidelines are not united, and previous research has not fully addressed existing conflicts. In this paper, problems associated with each nutrition pathway are reviewed to provide a clinical reference。
Key words: critical illness; malnutrition; enteral nutrition; parenteral nutrition
Hanzhi DAI , Sheng ZHANG , Ronghai. LIN . The latest developments in nutritional therapy pathways for patients in critical condition[J]. The Journal of Practical Medicine, 2024 , 40(4) : 585 -590 . DOI: 10.3969/j.issn.1006-5725.2024.04.026
| 1 | GOMES F, BAUMGARTNER A, BOUNOURE L, et al. Association of Nutritional Support With Clinical Outcomes Among Medical Inpatients Who Are Malnourished or at Nutritional Risk: An Updated Systematic Review and Meta-analysis[J]. JAMA Network Open, 2019, 2(11): e1915138. doi:10.1001/jamanetworkopen.2019.15138 |
| 2 | LEW C C H, YANDELL R, FRASER R J L, et al. Association Between Malnutrition and Clinical Outcomes in the Intensive Care Unit: A Systematic Review [Formula: see text][J]. JPEN, 2017, 41(5): 744-758. doi:10.1177/0148607115625638 |
| 3 | FENG X, LIU Z, HE X, et al. Risk of Malnutrition in Hospitalized COVID-19 Patients: A Systematic Review and Meta-Analysis[J]. Nutrients, 2022, 14(24): 5267. doi:10.3390/nu14245267 |
| 4 | JAVID Z, SHADNOUSH M, KHADEM-REZAIYAN M, et al. Nutritional adequacy in critically ill patients: Result of PNSI study[J]. Clin Nutrit (Edinburgh, Scotland), 2021, 40(2): 511-517. doi:10.1016/j.clnu.2020.05.047 |
| 5 | STOPPE C, DRESEN E, WENDT S, et al. Current practices in nutrition therapy in cardiac surgery patients: An international multicenter observational study[J]. JPEN, 2023, 47(5): 604-613. doi:10.1002/jpen.2495 |
| 6 | CHAPELA S P, MANZANARES W, QUESADA E, et al. Nutrition intake in critically ill patients with coronavirus disease (COVID-19): A nationwide, multicentre, observational study in Argentina[J]. Endocrinol Diab Nutr, 2023, 70(4): 245-254. doi:10.1016/j.endinu.2022.12.006 |
| 7 | SOLANA M J, MANRIQUE G, FERNáNDEZ R, et al. Nutritional status and nutrition support in critically ill children in Spain: Results of a multicentric study[J]. Nutrition, 2021, 84: 110993. doi:10.1016/j.nut.2020.110993 |
| 8 | PREISER J C, ICHAI C, ORBAN J C, et al. Metabolic response to the stress of critical illness[J]. Br J Anaesth, 2014, 113(6): 945-954. doi:10.1093/bja/aeu187 |
| 9 | STUMPF F, KELLER B, GRESSIES C, et al. Inflammation and Nutrition: Friend or Foe?[J]. Nutrients, 2023, 15(5): 1159. doi:10.3390/nu15051159 |
| 10 | HUET O, DUPIC L, BATTEUX F, et al. Postresuscitation syndrome: potential role of hydroxyl radical-induced endothelial cell damage[J]. Crit Care Med, 2011, 39(7): 1712-1720. doi:10.1097/ccm.0b013e3182186d42 |
| 11 | GREEN P, THEILLA M, SINGER P. Lipid metabolism in critical illness[J]. Curr Opinion Clin Nutrit Metabol Care, 2016, 19(2): 111-115. doi:10.1097/mco.0000000000000253 |
| 12 | KANOVA M, KOHOUT P. Molecular Mechanisms Underlying Intensive Care Unit-Acquired Weakness and Sarcopenia[J]. Int J Mol Sci, 2022, 23(15): 8396. doi:10.3390/ijms23158396 |
| 13 | EGGMANN S, LUDER G, VERRA M L, et al. Functional ability and quality of life in critical illness survivors with intensive care unit acquired weakness: A secondary analysis of a randomised controlled trial[J]. PloS One, 2020, 15(3): e0229725. doi:10.1371/journal.pone.0229725 |
| 14 | STUPAK D P, ABDELSAYED G G, SOLOWAY G N. Motility disorders of the upper gastrointestinal tract in the intensive care unit: pathophysiology and contemporary management[J]. J Clin Gastroenterol, 2012, 46(6): 449-456. doi:10.1097/mcg.0b013e31824e14c1 |
| 15 | REINTAM BLASER A, MALBRAIN M L N G, STARKOPF J, et al. Gastrointestinal function in intensive care patients: terminology, definitions and management. Recommendations of the ESICM Working Group on Abdominal Problems[J]. Intens Care Med, 2012, 38(3): 384-394. doi:10.1007/s00134-011-2459-y |
| 16 | HU B, SUN R, WU A, et al. Severity of acute gastrointestinal injury grade is a predictor of all-cause mortality in critically ill patients: a multicenter, prospective, observational study[J]. Crit Care (London, England), 2017, 21(1): 188. doi:10.1186/s13054-017-1780-4 |
| 17 | BOURCIER S, ULMANN G, JAMME M, et al. A multicentric prospective observational study of diagnosis and prognosis features in ICU mesenteric ischemia: the DIAGOMI study[J/OL]. Ann Intens Care, 2022, 12(1): 113. doi:10.1186/s13613-022-01092-8 |
| 18 | ZHOU X, LIAO Y. Gut-Lung Crosstalk in Sepsis-Induced Acute Lung Injury[J]. Front Microbiol, 2021, 12: 779620.. doi:10.3389/fmicb.2021.779620 |
| 19 | HABES Q L M, VAN EDE L, GERRETSEN J, et al. Norepinephrine Contributes to Enterocyte Damage in Septic Shock Patients: A Prospective Cohort Study[J]. Shock, 2018, 49(2): 137-143. doi:10.1097/shk.0000000000000955 |
| 20 | PITON G, CYPRIANI B, REGNARD J, et al. Catecholamine use is associated with enterocyte damage in critically ill patients[J]. Shock (Augusta, Ga.), 2015, 43(5): 437-442. doi:10.1097/shk.0000000000000327 |
| 21 | YANG X J, LIU D, REN H Y, et al. Effects of sepsis and its treatment measures on intestinal flora structure in critical care patients[J]. World J Gastroenterol, 2021, 27(19): 2376-2393. doi:10.3748/wjg.v27.i19.2376 |
| 22 | GE X, DING C, ZHAO W, et al. Antibiotics-induced depletion of mice microbiota induces changes in host serotonin biosynthesis and intestinal motility[J]. J Translat Med, 2017, 15(1): 13. doi:10.1186/s12967-016-1105-4 |
| 23 | MA T, XUE X, TIAN H, et al. Effect of the gut microbiota and their metabolites on postoperative intestinal motility and its underlying mechanisms[J]. J Translat Med, 2023, 21(1): 349. doi:10.1186/s12967-023-04215-2 |
| 24 | YAN Y, CHEN Y, ZHANG X. The effect of opioids on gastrointestinal function in the ICU[J]. Crit Care (London, England), 2021, 25(1): 370. doi:10.1186/s13054-021-03793-1 |
| 25 | RUEDA-RUZAFA L, CRUZ F, CARDONA D, et al. Opioid system influences gut-brain axis: Dysbiosis and related alterations[J]. Pharmacol Res, 2020, 159: 104928. doi:10.1016/j.phrs.2020.104928 |
| 26 | HOFFMANN M, SCHWARZ C M, FüRST S, et al. Risks in Management of Enteral Nutrition in Intensive Care Units: A Literature Review and Narrative Synthesis[J]. Nutrients, 2020, 13(1): 82. doi:10.3390/nu13010082 |
| 27 | DRESEN E, NOTZ Q, MENGER J, et al. What the clinician needs to know about medical nutrition therapy in critically ill patients in 2023: A narrative review[J/OL]. Nutrit Clin Pract, 2023, 38(3): 479-498. doi:10.1002/ncp.10984 |
| 28 | Chinese Society of Parenteral and Enteral Nutrition(CSPEN) [Guideline for clinical application of parenteral and enteral nutrition in adults patients in China (2023 edition)][J]. Zhonghua Yi Xuxue Za Zhi, 2023, 103(13):946-974. |
| 29 | PATEL J J, RICE T, HEYLAND D K. Safety and Outcomes of Early Enteral Nutrition in Circulatory Shock[J]. JPEN, 2020, 44(5): 779-784. doi:10.1002/jpen.1793 |
| 30 | QUIROZ-OLGUíN G, GUTIéRREZ-SALMEáN G, POSADAS-CALLEJA J G, et al. The effect of enteral stimulation on the immune response of the intestinal mucosa and its application in nutritional support[J/OL]. Euro J Clin Nutrit, 2021, 75(11): 1533-1539. doi:10.1038/s41430-021-00877-7 |
| 31 | HUI L, ZANG K, WANG M, et al. Comparison of the Preference of Nutritional Support for Patients With Severe Acute Pancreatitis[J]. Gastroenterol Nurs, 2019, 42(5): 411-416. doi:10.1097/sga.0000000000000331 |
| 32 | WU T, RAYNER C K, YOUNG R L, et al. Gut motility and enteroendocrine secretion[J]. Curr Opin Pharmacol, 2013, 13(6): 928-934. doi:10.1016/j.coph.2013.09.002 |
| 33 | LIU M, GAO C. A systematic review and meta-analysis of the effect of total parenteral nutrition and enteral nutrition on the prognosis of patients with acute pancreatitis[J]. Ann Palliat Med, 2021, 10(10): 10779-10788. doi:10.21037/apm-21-2469 |
| 34 | DOLEY J. Enteral Nutrition Overview[J]. Nutrients, 2022, 14(11): 2180. doi:10.3390/nu14112180 |
| 35 | TAYLOR B E, MCCLAVE S A, MARTINDALE R G, et al. Guidelines for the Provision and Assessment of Nutrition Support Therapy in the Adult Critically Ill Patient: Society of Critical Care Medicine (SCCM) and American Society for Parenteral and Enteral Nutrition (A.S.P.E.N.)[J]. Crit Care Med, 2016, 44(2): 390-438. doi:10.1097/ccm.0000000000001525 |
| 36 | SINGER P, BLASER A R, BERGER M M, et al. ESPEN guideline on clinical nutrition in the intensive care unit[J]. Clin Nutrit (Edinburgh, Scotland), 2019, 38(1): 48-79. doi:10.1016/j.clnu.2018.08.037 |
| 37 | PARDO E, LESCOT T, PREISER J C, et al. Association between early nutrition support and 28-day mortality in critically ill patients: the FRANS prospective nutrition cohort study[J/OL]. Crit Care (London, England), 2023, 27(1): 7. doi:10.1186/s13054-022-04298-1 |
| 38 | 王晓通, 孔凡彪, 李雷, 等. 肠内营养时机对消化道瘘急诊手术患者术后恢复的影响[J]. 实用医学杂志, 2020, 36(20): 2871-2875. doi:10.3969/j.issn.1006-5725.2020.20.026 |
| 39 | BAIU I, SPAIN D A. Enteral Nutrition[J]. JAMA, 2019, 321(20): 2040. doi:10.1001/jama.2019.4407 |
| 40 | LEDEBOER M, MASCLEE A A, BIEMOND I, et al. Effect of intragastric or intraduodenal administration of a polymeric diet on gallbladder motility, small-bowel transit time, and hormone release[J/OL]. Am J Gastroenterol, 1998, 93(11): 2089-2096. doi:10.1111/j.1572-0241.1998.00599.x |
| 41 | 赛航. 鼻空肠管和鼻胃管肠内营养对危重症患者胃泌素分泌的比较[D]. 广州:暨南大学, 2013. |
| 42 | LUTTIKHOLD J, VAN NORREN K, RIJNA H, et al. Jejunal feeding is followed by a greater rise in plasma cholecystokinin, peptide YY, glucagon-like peptide 1, and glucagon-like peptide 2 concentrations compared with gastric feeding in vivo in humans: a randomized trial[J]. Am J Clin Nutrit, 2016, 103(2): 435-443. doi:10.3945/ajcn.115.116251 |
| 43 | LIU Y, WANG Y, ZHANG B, et al. Gastric-tube versus post-pyloric feeding in critical patients: a systematic review and meta-analysis of pulmonary aspiration- and nutrition-related outcomes[J]. Euro J Clin Nutri, 2021, 75(9): 1337-1348. doi:10.1038/s41430-021-00860-2 |
| 44 | DAVIES A R, MORRISON S S, BAILEY M J, et al. A multicenter, randomized controlled trial comparing early nasojejunal with nasogastric nutrition in critical illness[J]. Crit Care Med, 2012, 40(8): 2342-2348. doi:10.1097/ccm.0b013e318255d87e |
| 45 | VINER SMITH E, RIDLEY E J, RAYNER C K, et al. Nutrition Management for Critically Ill Adult Patients Requiring Non-Invasive Ventilation: A Scoping Review[J]. Nutrients, 2022, 14(7): 1446. doi:10.3390/nu14071446 |
| 46 | DUTTA A K, GOEL A, KIRUBAKARAN R, et al. Nasogastric versus nasojejunal tube feeding for severe acute pancreatitis[J]. Cochr Datab System Rev, 2020, 3: CD010582. doi:10.1002/14651858.cd010582.pub2 |
| 47 | JAB?O?SKA B, MROWIEC S. Nutritional Support in Patients with Severe Acute Pancreatitis-Current Standards[J]. Nutrients, 2021, 13(5): 1498. doi:10.3390/nu13051498 |
| 48 | BERLANA D. Parenteral Nutrition Overview[J]. Nutrients, 2022, 14(21): 4480. doi:10.3390/nu14214480 |
| 49 | RAMANATHAN M, AADAM A A. Nutrition Management in Acute Pancreatitis[J]. Nutrit Clin Pract, 2019, 34(): S7-S12. doi:10.1002/ncp.10386 |
| 50 | WANG P, SUN H, MAITIABULA G, et al. Total parenteral nutrition impairs glucose metabolism by modifying the gut microbiome[J/OL]. Nature Metabolism, 2023, 5(2): 331-348. doi:10.1038/s42255-023-00744-8 |
| 51 | HENEGHAN A F, PIERRE J F, KUDSK K A. IL-25 improves IgA levels during parenteral nutrition through the JAK-STAT pathway[J]. Ann Surg, 2013, 258(6): 1065-1071. doi:10.1097/sla.0b013e318277ea9e |
| 52 | ELKE G, HARTL W H, KREYMANN K G, et al. Clinical Nutrition in Critical Care Medicine-Guideline of the German Society for Nutritional Medicine (DGEM)[J]. Clin Nutrit ESPEN, 2019, 33: 220-275. doi:10.1016/j.clnesp.2019.05.002 |
| 53 | COMPHER C, BINGHAM A L, MCCALL M, et al. Guidelines for the provision of nutrition support therapy in the adult critically ill patient: The American Society for Parenteral and Enteral Nutrition[J]. JPEN J Parent Enter Nutrit, 2022, 46(1): 12-41. doi:10.1002/jpen.2267 |
| 54 | EVANS L, RHODES A, ALHAZZANI W, et al. Surviving sepsis campaign: international guidelines for management of sepsis and septic shock 2021[J]. Intens Care Med, 2021, 47(11): 1181-1247. |
| 55 | HARTMAN C, SHAMIR R, SIMCHOWITZ V, et al. ESPGHAN/ESPEN/ESPR/CSPEN guidelines on pediatric parenteral nutrition: Complications[J]. Clini Nutrit (Edinburgh, Scotland), 2018, 37(6 Pt B): 2418-2429. doi:10.1016/j.clnu.2018.06.956 |
| 56 | BOULLATA J I, GILBERT K, SACKS G, et al. A.S.P.E.N. clinical guidelines: parenteral nutrition ordering, order review, compounding, labeling, and dispensing[J/OL]. J Parent Ent Nutr, 2014, 38(3): 334-377. doi:10.1177/0148607114521833 |
| 57 | MARSH N, WEBSTER J, ULLMAN A J, et al. Peripheral intravenous catheter non-infectious complications in adults: A systematic review and meta-analysis[J]. J Advan Nurs, 2020, 76(12): 3346-3362. doi:10.1111/jan.14565 |
| 58 | LU H, YANG Q, TIAN B, et al. A meta-analysis of the comparison of phlebitis between midline catheters and peripherally inserted central catheters in infusion therapy[J]. Int J Nurs Pract, 2022, 28(2): e12976. doi:10.1111/ijn.12976 |
| 59 | URTECHO M, TORRES ROLDAN V D, NAYFEH T, et al. Comparing Complication Rates of Midline Catheter vs Peripherally Inserted Central Catheter. A Systematic Review and Meta-analysis[J]. Open Forum Infect Dis, 2023, 10(2): ofad024. doi:10.1093/ofid/ofad024 |
| 60 | SANTOS F K Y, FLUMIGNAN R L G, AREIAS L L, et al. Peripherally inserted central catheter versus central venous catheter for intravenous access: A protocol for systematic review and meta-analysis[J/OL]. Medicine, 2020, 99(30): e20352. doi:10.1097/md.0000000000020352 |
| 61 | PITIRIGA V, KANELLOPOULOS P, BAKALIS I, et al. Central venous catheter-related bloodstream infection and colonization: the impact of insertion site and distribution of multidrug-resistant pathogens[J]. Antimicro Resist Infect Control, 2020, 9(1): 189. doi:10.1186/s13756-020-00851-1 |
| 62 | PITIRIGA V, BAKALIS J, THEODORIDOU K, et al. Lower risk of bloodstream infections for peripherally inserted central catheters compared to central venous catheters in critically ill patients[J]. Antimicro Resist Infect Control, 2022, 11(1): 137. doi:10.1186/s13756-022-01180-1 |
| 63 | LAFUENTE CABRERO E, TERRADAS ROBLEDO R, CIVIT CU?ADO A, et al. Risk factors of catheter- associated bloodstream infection: Systematic review and meta-analysis[J]. PLoS One, 2023, 18(3): e0282290. doi:10.1371/journal.pone.0282290 |
| 64 | MILLINGTON S J, COLVIN M O, SHILOH A L, et al. How I Do It: Ultrasound-Guided Internal Jugular and Femoral Central Venous Catheter Insertion[J]. Chest, 2020, 158(6): 2425-2430. doi:10.1016/j.chest.2020.06.026 |
| 65 | SUN H, BI J, LEI Q, et al. Partial enteral nutrition increases intestinal sIgA levels in mice undergoing parenteral nutrition in a dose-dependent manner[J]. Int J Surg (London, England), 2018, 49: 74-79. doi:10.1016/j.ijsu.2017.12.011 |
| 66 | QIN Y, LIU M, GUO F, et al. The Efficacy of Parenteral Nutrition and Enteral Nutrition Supports in Traumatic Brain Injury: A Systemic Review and Network Meta-Analysis[J]. Emerg Med Int, 2023, 2023: 8867614. doi:10.1155/2023/8867614 |
| 67 | LUO Y, QIAN Y. Effect of combined parenteral and enteral nutrition for patients with a critical illness: A meta-analysis of randomized controlled trials[J]. Medicine, 2020, 99(3): e18778. doi:10.1097/md.0000000000018778 |
/
| 〈 |
|
〉 |