The Journal of Practical Medicine >
A clinicopathological analysis of cervical carcinoma with basaloid features
Received date: 2023-07-10
Online published: 2024-03-06
Objective To investigate the clinical and pathological features of adenoid basal cell carcinoma (ABC), adenoid cystic carcinoma (ACC), and basaloid squamous cell carcinoma (BSCC) with basaloid characteristics and improve the diagnostic and differential diagnostic ability of clinicians and pathologists for these lesions. Methods A retrospective study was conducted on the clinical and pathological data of 4 cases of ABC, 1 case of ACC, and 3 cases of BSCC diagnosed and treated at Shenzhen Maternal and Child Health Hospital, Southern Medical University from April 2018 to December 2022. Pathological slides were reviewed and relevant literature was analyzed and summarized. Results All three types of tumors were common in postmenopausal women and were associated with high-risk HPV infection. ABC was a low-grade cancer and patients were often clinically asymptomatic. It was usually detected incidentally during cervical screening due to cytological abnormalities, or after cervical cone biopsy or hysterectomy for HSIL. It presented as superficial cervical infiltration and clinical staging was often early. ACC and BSCC were intermediate to high-grade cancers and they often presented with postmenopausal vaginal bleeding. A visible mass was observed on the cervix. The clinical staging was intermediate to advanced. The three types of lesions could coexist. Careful observation of the morphological characteristics and immunohistochemical staining could help with differential diagnosis. None of the 8 patients experienced recurrence or metastasis during follow-up. Conclusion Cervical ABC, ACC and BSCC are rare and they originate from reserve cells. They share the similarities in clinical and pathological morphology, but differ in treatment and prognosis. So, accurate differentiation among them has important clinical significance.
Yanrui ZHANG , Xinyi HUANG , Jian SHI , Yihui YANG , Limin LIU , Haiyan HU . A clinicopathological analysis of cervical carcinoma with basaloid features[J]. The Journal of Practical Medicine, 2024 , 40(2) : 163 -168 . DOI: 10.3969/j.issn.1006-5725.2024.02.007
| 1 | BAGGISH M S, WOODRUFF J D. Adenoid-basal carcinoma of the cervix[J]. Obstet Gynecol, 1966, 28(2):213-218. doi:10.1097/00003081-196608000-00013 |
| 2 | PAALMAN R J, COUNSELLER V S. Clyindroma of the cervix with procidentia[J]. Am J Obstet Gynecol, 1949, 58(1):184-187. doi:10.1016/0002-9378(49)90024-1 |
| 3 | MCGEE J A, FLOWERS C E, TATUM B S. Adenoid Cystic Carcinoma of the Cervix:Report of a Case[J]. Obstet Gynecol,1965, 26:356-358. |
| 4 | KWON Y S, KIM Y M, CHOI G W, et al. Pure basaloid squamous cell carcinoma of the uterine cervix: a case report[J]. J Korean Med Sci,2009, 24(3):542-545. doi:10.3346/jkms.2009.24.3.542 |
| 5 | 何德明,吴饶平,秦赟娜,等. 子宫颈腺样基底细胞癌12例临床病理特征分析[J].临床与实验病理学杂志,2015,31 (5):510-513. |
| 6 | 赵月,孙平丽,何洋洋,等. 宫颈所谓的腺样囊性癌临床病理学特征及进展[J]. 中华病理学杂志,2022, 51(4):385-388. doi:10.3760/cma.j.cn112151-20210828-00623 |
| 7 | 王利群,王昀,晋薇,等. 子宫颈基底样鳞癌的临床病理分析[J]. 中华妇产科杂志, 2019,54(1):7-12. doi:10.3760/cma.j.issn.0529-567x.2019.01.003 |
| 8 | SHI H, SHAO Y, LIU Q, et al. A clinicopathological and molecular analysis of cervical carcinomas with basaloid features[J]. Histopathology,2020, 76(2): 283?295. doi:10.1111/his.13968 |
| 9 | 赵月,孙平丽,于世利,等. 宫颈腺样囊性癌5例临床病理分析[J]. 中华病理学杂志,2022,51(11):1161-1163. |
| 10 | GRAYSON W, TAYLOR L F, COOPER K. Adenoid basal carcinoma of the uterine cervix: detection of integrated human papillomavirus in a rare tumor of putative "reserve cell" origin[J]. Int J Gynecol Pathol, 1997,16(4):307-312. doi:10.1097/00004347-199710000-00003 |
| 11 | JONES M W, KOUNELIS S, PAPADAKI H,et al. The origin and molecular characterization of adenoid basal carcinoma of the uterine cervic[J]. Int J Gynecol Pathol,1997,16(4):301-306. doi:10.1097/00004347-199710000-00002 |
| 12 | XING D, SCHOO LMEESTER J K, REN Z, et al. Lower femalegenital tract tumors with adenoid cystic differentiation: p16 expression and high?risk HPV detection[J]. Am J Surg Pathol,2016, 40(4):529-536. doi:10.1097/pas.0000000000000565 |
| 13 | RUSSELL M J, FADARE O. Adenoid basal lesions of the uterine cervix: evolving terminology and clinicopathological concepts[J]. Diagn Pathol,2006,1:18. doi:10.1186/1746-1596-1-18 |
| 14 | 薛德彬,主 译. Blaustein女性生殖道病理学[M]. 6版.北京:北京科学技术出版社, 2012: 252-276. |
| 15 | 江庆萍,王昀,胡丹,主 译. 妇科病理学图谱[M]. 4版. 北京:中国科学技术出版社, 2022:129-159. |
| 16 | KURMAN R, CARCANGIU M L, HERRINGTON C S,et al .WHO classification of tumours of female reproductive organs[M]. 4 ed. Lyon:IARC Publications, 2014. |
| 17 | WHO classification of tumours: Female genital tumours[M]. Lyon (Frence): International Agency for Research on cancer, 2020. |
| 18 | 赵婧,罗荣奎,周先荣,等. 宫颈腺样基底细胞癌的临床病理学特征分析[J]. 诊断病理学杂志,2017, 24(6):450-454. doi:10.3969/j.issn.1007-8096.2017.06.012 |
| 19 | PARWANI A V, SMITH S A, KURMAN R J, et al. Cervical adenoid basal tumors comprised of adenoid basal epithelioma associated with various types of invasive carcinoma: clinicopathologic features, human papillomavirus DNA detection, and p16 expression[J]. Hum Pathol,2005,36(1):82-90. doi:10.1016/j.humpath.2004.08.015 |
| 20 | JEONG J, HA S Y, CHO H Y, et al. Comparison of cytologic characteristics between adenoid cystic carcinoma and adenoid basal carcinoma in the uterine cervix[J]. J Pathol Transl Med,2015,49(5):396-402. doi:10.4132/jptm.2015.07.08 |
| 21 | XING D, LU J. Distinctive clinicopathological features and disease?specific survival of adenoid cystic carcinoma and adenoid basal carcinoma in the lower female genital tract[J]. Oncol Rep,2019, 41(3): 1769-1778. |
| 22 | FREGNANI J H, SOARES F A, NOVIK P R, et al. Comparison of biological behavior between early?stage adenocarcinoma and squamous cell carcinoma of the uterine cervix[J]. Eur J Obstet Gynecol Reprod Biol,2008, 136(2):215-223. doi:10.1016/j.ejogrb.2006.10.021 |
| 23 | KOYFMAN S A, ABIDI A, RAVICHANDRAN P, et al. Adenoid cystic carcinoma of the cervix[J]. Gynecol Oncol,2005, 99(2):477-480. doi:10.1016/j.ygyno.2005.06.063 |
| 24 | 刘倩,王玮. 浅谈宫颈癌临床治疗新进展[J]. 实用医学杂志, 2018, 34(1):5-7. doi:10.3969/j.issn.1006-5725.2018.01.002 |
| 25 | 陈默,黄荣. 调强放射治疗条件下根治性宫颈癌的长期生存报道[J]. 实用医学杂志, 2020, 36(20):2810-2814. doi:10.3969/j.issn.1006-5725.2020.20.013 |
| 26 | 周晖,刘昀昀,罗铭,等.《2023NCCN子宫颈癌临床实践指南(第1版)》解读[J]. 中国实用妇科与产科杂志,2023, 39(2):189-196. |
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