The Journal of Practical Medicine >

2024 , Vol. 40 >Issue 2: 129 - 132

DOI: https://doi.org/10.3969/j.issn.1006-5725.2024.02.001

Symposiums

Application and prospects of ctDNA detection in HPV associated cervical cancer

  • Baoni JIANG ,
  • Meiqin ZHANG ,
  • Lu YANG ,
  • Zhiyuan CHEN ,
  • Na′na HAN
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  • Obstetrics and Gynecology Medical Center of the Zhujiang Hospital of Southern Medical University，Guangzhou 510280，China

Received date: 2023-06-06

  Online published: 2024-03-06

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Abstract

Circulating tumor DNA （ctDNA） is a kind of cell-free DNA derived from tumors， which carries comprehensive tumor genetic information； Recent studies have found that ctDNA detection can play a role in the early diagnosis， targeted therapy， and prediction of recurrence in tumors. Human papillomavirus （HPV）-associated gynecological malignancies include most cervical cancer， some vulvar cancer， and vaginal cancer. High-risk HPV long-term infection and integration with cell genome are important causes of these cancers. Studies found that the use of ctDNA detection technology to dynamically monitor changes in HPV-ctDNA can provide valuable information for the clinical management and prognosis of these cancers. Thus， HPV-ctDNA is expected to become an biomarker for HPV- associated tumors.

Key words： HPV-ctDNA; HPV; cervical cancer; gynecologic malignancy; vulva cancer; vagina cancer

Cite this article

Baoni JIANG , Meiqin ZHANG , Lu YANG , Zhiyuan CHEN , Na′na HAN . Application and prospects of ctDNA detection in HPV associated cervical cancer[J]. The Journal of Practical Medicine, 2024 , 40(2) : 129 -132 . DOI: 10.3969/j.issn.1006-5725.2024.02.001

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