The Journal of Practical Medicine >
Effects of Diosmine on semen quality and sex hormone concentration in patients with spermatovenous ligation
Received date: 2023-07-31
Online published: 2024-02-22
Objective To investigate the effect of diosmine on semen quality and sex hormone concentration in patients with spermatovenous ligation. Methods Clinical data were retrospectively collected from January 2019 to January 2022 on patients with varicocele admitted to Department of Urology， General Hospital of Southern Theater Command， divided into a control group and a study group based on whether they had a history of Diosmine use after surgery. Clinical data from both groups were matched using propensity score matching. Sperm quality and sex hormone tests were then compared before surgery， three months after surgery and six months after surgery. Results There were 73 in the control group and 73 in the study group. Both groups were balanced in terms of age， BMI， seminal fluid volume and testosterone （P > 0.05）. Sperm motility， forward motility and testosterone were all increased 3 and 6 months after surgery， and sperm malformations， sperm DNA fragment index， follicle stimulating hormone and luteinizing hormone were all reduced significantly （P < 0.05）. The results were also better than those in the control group for total sperm motility， forward motility， testosterone， sperm DNA fragment index， follicle stimulating hormone and luteinizing hormone （P < 0.05）. Conclusions Diosmine can help to restore semen quality and improve sex hormone concentration in patients with varicocele after Laparoscopic varicocelectomy.
Key words： varicocele; semen quality; laparoscopic varicocelectomy; diosmine
Kaiqiang WANG , Zhi CAO , Wei WANG , Chenglin YANG , Yue YANG , Huifen ZHANG , Xaioming ZHANG . Effects of Diosmine on semen quality and sex hormone concentration in patients with spermatovenous ligation[J]. The Journal of Practical Medicine, 2024 , 40(3) : 389 -393 . DOI: 10.3969/j.issn.1006-5725.2024.03.019
| 1 | MINHAS S， BETTOCCHI C， BOERI L， et al. European Association of Urology Guidelines on Male Sexual and Reproductive Health： 2021 Update on Male Infertility［J］. Eur Urol， 2021，80（5）：603-620. doi:10.1016/j.eururo.2021.08.014 |
| 2 | VAN BATAVIA J P， LAWTON E， FRAZIER J R， et al. Total Motile Sperm Count in Adolescent Boys with Varicocele is Associated with Hormone Levels and Total Testicular Volume［J］. J Urol， 2021，205（3）：888-894. doi:10.1097/ju.0000000000001405 |
| 3 | BARATI E， NIKZAD H， KARIMIAN M. Oxidative stress and male infertility： current knowledge of pathophysiology and role of antioxidant therapy in disease management［J］. Cell Mol Life Sci，2020，77（1）：93-113. doi:10.1007/s00018-019-03253-8 |
| 4 | 黄健，钟光俊. 精索静脉曲张的手术治疗进展［J］. 国际泌尿系统杂志， 2021，41（5）：936-938. doi:10.3760/cma.j.cn431460-20200209-00045 |
| 5 | SAYLAM B， CAYAN S， AKBAY E. Effect of microsurgical varicocele repair on sexual functions and testosterone in hypogonadal infertile men with varicocele［J］. Aging Male， 2020，23（5）：1366-1373. doi:10.1080/13685538.2020.1769589 |
| 6 | FANG Y， SU Y， XU J， et al. Varicocele-Mediated Male Infertility： From the Perspective of Testicular Immunity and Inflammation［J］. Front Immunol， 2021，12：729539. doi:10.3389/fimmu.2021.729539 |
| 7 | FRANCO A， PROIETTI F， PALOMBI V， et al. Varicocele： To Treat or Not to Treat？［J］. J Clin Med， 2023，12（12）：4062. doi:10.3390/jcm12124062 |
| 8 | ZHENG Y， ZHANG R， SHI W， et al. Metabolism and pharmacological activities of the natural health-benefiting compound diosmin［J］. Food Funct， 2020，11（10）：8472-8492. doi:10.1039/d0fo01598a |
| 9 | 邓春华，商学军，孙祥宙，等. 精索静脉曲张诊断与治疗指南［J］. 中华男科学杂志，2022，28（8）：756-767. |
| 10 | GESHNIGANI S， MAHDAVINIA M， KALANTAR M， et al. Diosmin prophylaxis reduces gentamicin-induced kidney damage in rats［J］. Naunyn Schmiedebergs Arch Pharmacol， 2023，396（1）：63-71. doi:10.1007/s00210-022-02295-3 |
| 11 | ABOU-ELGHAIT A T， ELGAMAL D A， ABD E N， et al. Novel protective effect of diosmin against cisplatin-induced prostate and seminal vesicle damage： Role of oxidative stress and apoptosis［J］. Tissue Cell， 2022，79：101961. doi:10.1016/j.tice.2022.101961 |
| 12 | BAHAR O， ERASLAN G. Investigation of the efficacy of diosmin against organ damage caused by bendiocarb in male Wistar albino rats［J］. Environ Sci Pollut Res Int， 2023，30（19）：55826-55845. doi:10.1007/s11356-023-26105-2 |
| 13 | 刘心伟，李永伟，杨曦明，等. 临床实验室精液常规检验中国专家共识［J］. 中华检验医学杂志， 2022，45（8）：802-812. |
| 14 | 杨成林，王凯强，王尉，等. 经脐单孔腹腔镜下精准五步法保留睾丸动脉的精索内静脉高位结扎术治疗精索静脉曲张［J］. 实用医学杂志， 2023，39（7）：881-885. |
| 15 | MORETTI E， SIGNORINI C， CORSARO R， et al. Apelin is found in human sperm and testis and is raised in inflammatory pathological conditions［J］. Cytokine， 2023，169：156281. doi:10.1016/j.cyto.2023.156281 |
| 16 | ERFANI M N， SADEGHI N， TAVALAEE M， et al. Evaluation of Oxidative Stress in Testis and Sperm of Rat Following Induced Varicocele［J］. Urol J， 2019，16（3）：300-306. |
| 17 | AGARWAL A， CANNARELLA R， SALEH R， et al. Impact of Antioxidant Therapy on Natural Pregnancy Outcomes and Semen Parameters in Infertile Men： A Systematic Review and Meta-Analysis of Randomized Controlled Trials［J］. World J Mens Health， 2023，41（1）：14-48. doi:10.5534/wjmh.220067 |
| 18 | TSAMPOUKAS G， GKEKA K， DELLIS A， et al. Vitamins as primary or adjunctive treatment in infertile men with varicocele： A systematic review［J］. Arab J Urol， 2021，19（3）：264-273. doi:10.1080/2090598x.2021.1932124 |
| 19 | 李宏军. 精索静脉曲张手术后患者的管理策略［J］. 中华泌尿外科杂志， 2020，41（4）：247-250. doi:10.3760/cma.j.cn112330-20200311-00187 |
| 20 | MIRZAEE S， MANSOURI E， SHIRANI M， et al. Diosmin ameliorative effects on oxidative stress and fibrosis in paraquat-induced lung injury in mice［J］. Environ Sci Pollut Res Int，2019， 26（36）：36468-36477. doi:10.1007/s11356-019-06572-2 |
| 21 | ALI F， SAYED A M， EL-BAHRAWY A H， et al. Targeting KEAP1/Nrf2， AKT， and PPAR-gamma signals as a potential protective mechanism of diosmin against gentamicin-induced nephrotoxicity［J］. Life Sci， 2021，275：119349. doi:10.1016/j.lfs.2021.119349 |
| 22 | 董蓓蓓，邵松泽. 地奥司明联合七叶皂苷钠防治混合痔术后创缘水肿的临床观察［J］. 中国实用医刊， 2020，47（7）：102-104. doi:10.3760/cma.j.cn115689-20191023-07806 |
| 23 | 田汝辉，李朋，王俊龙，等. 精索静脉显微结扎术联合七叶皂苷治疗精索静脉曲张的有效性与安全性［J］. 中华医学杂志，2015，95（36）：2910-2913. doi:10.3760/cma.j.issn.0376-2491.2015.36.005 |
| 24 | 丁吉阳，蒋立城. 精索静脉曲张诊治的研究进展［J］. 国际泌尿系统杂志， 2018，38（3）：501-505. doi:10.3760/cma.j.issn.1673-4416.2018.03.041 |
| 25 | REIFFEL J A. Propensity Score Matching： The 'Devil is in the Details' Where More May Be Hidden than You Know［J］. Am J Med， 2020，133（2）：178-181. doi:10.1016/j.amjmed.2019.08.055 |
| 26 | 秦红平，莫少康，阎一鑫，等. 显微镜下精索静脉结扎术对血清睾酮/雌二醇比值的影响［J］. 生殖医学杂志，2021，30（9）：1175-1179. doi:10.3969/j.issn.1004-3845.2021.09.010 |
/
| 〈 |
|
〉 |