The Journal of Practical Medicine >

2024 , Vol. 40 >Issue 1: 53 - 58

DOI: https://doi.org/10.3969/j.issn.1006-5725.2024.01.010

Clinical Advances

Application and research progress of nanotechnology in atherosclerosis

  • Tingting WANG ,
  • Lili YU ,
  • Xiangli SHEN ,
  • Junmeng ZHENG ,
  • Yushan CHEN ,
  • Shasha SHANG ,
  • Jianru. WANG
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  • *.The First Clinical Medical College，He’nan University of Chinese Medicine，Zhengzhou 450000，China

Received date: 2023-05-18

  Online published: 2024-01-24

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Abstract

Atherosclerosis （AS） is a common cardiovascular disease， and its treatment and prevention have been the focus of medical research. AS an emerging technology， nanotechnology has unique advantages and plays an important role in the prevention， diagnosis and treatment of AS. This paper reviews the latest research on the application of nanotechnology in AS diseases， systematically discusses the role of nanotechnology in the diagnosis and treatment of AS， and comprehensively analyzes the effects of nano-drug carriers based on different surface trimmers， loading diagnostic and therapeutic drugs so as to monitordisease progression of AS and its targeted treatment. The aim is to provide new thought for the clinical treatment of AS.

Key words： atherosclerosis; nanotechnology; targeting effect; nanoprobe

Cite this article

Tingting WANG , Lili YU , Xiangli SHEN , Junmeng ZHENG , Yushan CHEN , Shasha SHANG , Jianru. WANG . Application and research progress of nanotechnology in atherosclerosis[J]. The Journal of Practical Medicine, 2024 , 40(1) : 53 -58 . DOI: 10.3969/j.issn.1006-5725.2024.01.010

References

1 LANKALA C R， YASIR M， ISHAK A， et al. Application of Nanotechnology for Diagnosis and Drug Delivery in Atherosclerosis： A New Horizon of Treatment［J］. Curr Probl Cardiol， 2023： 101671.
2 王单单. MR与多层螺旋CT对诊断颈动脉狭窄和粥样硬化斑块的临床应用价值分析［J］. 中外医学研究，2022，20（26）：78-81.
3 SINGH S B， NG S J， LAU H C， et al. Emerging PET tracers in cardiac molecular imaging［J］. Cardiol Ther， 2023， 12（1）： 85-99.
4 STOJKOVIC S， KAMPF S， HARKOT O， et al. Soluble ST2 in Patients with Carotid Artery Stenosis-Association with Plaque Morphology and Long-Term Outcome［J］. Int J Mol Sci， 2023， 24（10）： 9007.
5 LI Q， CAI M， WANG H， et al. Diagnostic Performance of Contrast‐Enhanced Ultrasound and High‐Resolution Magnetic Resonance Imaging for Carotid Atherosclerotic Plaques： A Systematic Review and Meta‐Analysis［J］. J Ultrasound Med， 2022，42（3）：739-749.
6 SONGCA S P. Combinations of Photodynamic Therapy with Other Minimally Invasive Therapeutic Technologies against Cancer and Microbial Infections［J］. Int J Mol Sci， 2023， 24（13）： 10875.
7 ZHANG X， CENTURION F， MISRA A， et al. Molecularly targeted nanomedicine enabled by inorganic nanoparticles for atherosclerosis diagnosis and treatment［J］. Adv Drug Deliv Rev， 2023，194：114709.
8 WU Q， PAN W， WU G， et al. CD40-targeting magnetic nanoparticles for MRI/optical dual-modality molecular imaging of vulnerable atherosclerotic plaques［J］. Atherosclerosis， 2023， 369： 17-26.
9 WANG Y， FENG Y， YANG X， et al. Diagnosis of Atherosclerotic Plaques Using Vascular Endothelial Growth Factor Receptor-2 Targeting Antibody Nano-microbubble as Ultrasound Contrast Agent ［J］. Comput Math Methods Med， 2022， 2022：6524592.
10 LI P， JIN L， FENG L， et al. ICAM-1-carrying targeted nano contrast agent for evaluating inflammatory injury in rabbits with atherosclerosis ［J］. Sci Rep， 2021， 11（1）： 1-10.
11 FEIL S， STOWBUR D， SCHORG B F， et al. Noninvasive Detection of Smooth Muscle Cell-Derived Hot Spots to Study Atherosclerosis by PET/MRI in Mice［J］. Circul Res， 2023， 132（6）： 747-750.
12 IMRAN M， JHA L A， HASAN N， et al. “Nanodecoys”-Future of drug delivery by encapsulating nanoparticles in natural cell membranes ［J］. Int J Pharm， 2022： 121790.
13 BONNET S， PRéVOT G， MORNET S， et al. A nano-emulsion platform functionalized with a fully human scfv-fc antibody for atheroma targeting： Towards a theranostic approach to atherosclerosis ［J］. Int J Mol Sci， 2021， 22（10）： 5188.
14 ZHANG Y， YIN Y， ZHANG W， et al. Reactive oxygen species scavenging and inflammation mitigation enabled by biomimetic prussian blue analogues boycott atherosclerosis ［J］. J Nanobiotechnology， 2021， 19（1）： 1-13.
15 CHEN W， SCHILPEROORT M， CAO Y， et al. Macrophage-targeted nanomedicine for the diagnosis and treatment of atherosclerosis ［J］. Nat Rev Cardiol， 2022， 19（4）： 228-249.
16 WU M， LI X， GUO Q， et al. Magnetic mesoporous silica nanoparticles-aided dual MR/NIRF imaging to identify macrophage enrichment in atherosclerotic plaques ［J］. Nanomedicine， 2021， 32： 102330.
17 JIANG Z， GENG X， SU L， et al. Neutrophil membrane camouflaged nanoprobes for NIR-II fluorescence imaging of inflamed， high-risk atherosclerotic plaques in mouse and rabbit models ［J］. Mat Today Chem， 2022， 26： 101062.
18 WANG Q， LOU R， YIN Q， et al. A nano-detection system based on a chemical probe for early diagnosis of atherosclerosis in situ ［J］. Analyst， 2021， 146（14）： 4674-4682.
19 LIN L， WANG L V. The emerging role of photoacoustic imaging in clinical oncology［J］. Nat Rev Clin Oncol， 2022， 19（6）： 365-384.
20 JIANG Y W， TANG W J， GAO G， et al. Lipid droplet-hitchhiking probe creates Trojan foam cells for fluorescence/photoacoustic imaging of atherosclerotic plaques［J］. Biosensors Bioelectron， 2022， 216： 114613.
21 DENG H， KONOPKA C J， PRABHU S， et al. Dextran-Mimetic Quantum Dots for Multimodal Macrophage Imaging In Vivo， Ex Vivo， and In Situ［J］. ACS Nano， 2022， 16（2）： 1999-2012.
22 WU K， YAO C， YANG D， et al. A functional DNA nanosensor for highly sensitive and selective imaging of ClO- in atherosclerotic plaques ［J］. Biosensors Bioelectron， 2022， 209： 114273.
23 OUYANG J， XIE A， ZHOU J， et al. Minimally invasive nanomedicine： nanotechnology in photo-/ultrasound-/radiation-/magnetism-mediated therapy and imaging［J］. Chem Soc Rev， 2022， 51（12）：4996-5041.
24 SULTAN D， LI W， DETERING L， et al. Assessment of ultrasmall nanocluster for early and accurate detection of atherosclerosis using positron emission tomography/computed tomography ［J］. Nanomedicine， 2021， 36： 102416.
25 LIU M， ZHANG Y， MA X， et al. Synthesis and Characterization of Fucoidan-Chitosan Nanoparticles Targeting P-Selectin for Effective Atherosclerosis Therapy［J］. Oxid Med Cell Longev， 2022， 2022： 8006642.
26 LI G， XU F， YANG B， et al. A nanotherapy responsive to the inflammatory microenvironment for the dual-targeted treatment of atherosclerosis［J］. Nanomedicine， 2022， 43： 102557.
27 HUANG X， LIU C， KONG N， et al. Synthesis of siRNA nanoparticles to silence plaque-destabilizing gene in atherosclerotic lesional macrophages［J］. Nat Protoc， 2022， 17（3）： 748-780.
28 CHIN D D， POON C， WANG J， et al. miR-145 micelles mitigate atherosclerosis by modulating vascular smooth muscle cell phenotype ［J］. Biomaterials， 2021， 273： 120810.
29 GUO L， MIAO Y， WANG Y， et al. Biomimetic Macrophage Membrane and Lipidated Peptide Hybrid Nanovesicles for Atherosclerosis Therapy ［J］. Adv Func Mat， 2022： 2204822.
30 MA X， ZHANG T， LUO Z， et al. Functional nano-vector boost anti-atherosclerosis efficacy of berberine in Apoe （-/-） mice ［J］. Acta Pharm Sin B， 2020， 10（9）： 1769-1783.
31 WANG S， ZHOU Y， LIANG X， et al. Platinum-cerium bimetallic nano-raspberry for atherosclerosis treatment via synergistic foam cell inhibition and P2Y12 targeted antiplatelet aggregation ［J］. Chem Engin J， 2022， 430： 132859.
32 SUN W， XU Y， YAO Y， et al. Self-oxygenation mesoporous MnO2 nanoparticles with ultra-high drug loading capacity for targeted arteriosclerosis therapy ［J］. J Nanobiotechnol， 2022， 20（1）： 1-17.
33 WU Z， WU R， LI X， et al. Multi‐pathway microenvironment regulation for atherosclerosis therapy based on beta‐cyclodextrin/l‐arginine/Au nanomotors with dual‐mode propulsion［J］. Small， 2022， 18（9）： 2104120.
34 ZHOU J， NIU C， BIVING H， et al. Platelet membrane biomimetic nanoparticles combined with UTMD to improve the stability of atherosclerotic plaques ［J］. Front Chem， 2022， 2022： 191.
35 YIN M， LIN J， YANG M， et al. Platelet membrane-cloaked selenium/ginsenoside Rb1 nanosystem as biomimetic reactor for atherosclerosis therapy ［J］. Colloids Surf B Biointerfaces， 2022， 214： 112464.
36 ZHOU H， YOU P， LIU H， et al. Artemisinin and Procyanidins loaded multifunctional nanocomplexes alleviate atherosclerosis via simultaneously modulating lipid influx and cholesterol efflux ［J］. J Controll Rel， 2022， 341： 828-843.
37 PU H， YAO M， WU Z， et al. Regulation of the macrophage-related inflammatory microenvironment for atherosclerosis treatment and angiogenesis via anti-cytokine agents ［J］. Nano Res， 2022， 2022： 1-13.
38 SALAHEIDIN T A， GODUGU K， BHARALI D J， et al. Novel oral nano-hepatic targeted anti-PCSK9 in hypercholesterolemia ［J］. Nanomedicine， 2022， 40： 102480.
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