The Journal of Practical Medicine >

2024 , Vol. 40 >Issue 1: 32 - 37

DOI: https://doi.org/10.3969/j.issn.1006-5725.2024.01.006

Feature Reports：Lung cancer

Clinical efficacy of CalliSpheres drug⁃loaded microspheres versus blank microspheres in the treatment of advanced non⁃small cell lung cancer by transarterial chemoembolization

  • Ruiwen CHENG ,
  • Ruobing HAO ,
  • Ping LI ,
  • Kun ZHANG ,
  • Liping DENG ,
  • Yaheng CAO ,
  • Lin SU ,
  • Hongrong. SHEN
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  • *.Department of Vascular and Tumor Intervention，the First Affiliated Hospital of Hunan University of Chinese Medicine，Changsha 410021，China

Received date: 2023-07-12

  Online published: 2024-01-24

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Abstract

Objective To analyze and compare the clinical efficacy of CalliSpheres drug-eluting microspheres and blank microspheres in the treatment of advanced non-small cell lung cancer by bronchial arterial chemoembolization. Methods Fifty patients with advanced non-small cell lung cancer who had failed or relapsed after radiotherapy， chemotherapy， targeting and immunotherapy were collected and treated with super-selective bronchial artery chemoembolization. A retrospective analysis was conducted to compare the tumor response rate and survival between CalliSpheres drug-eluting and blank microspheres. Results The PR， ORR and DCR in the drug-eluted microsphere group were higher than those in the blank microsphere group， and there was a statistical difference in DCR between the two groups 1 month after surgery （χ2 = 4.08， P = 0.04）. PD in the drug-eluted microsphere group was lower than that in the blank microsphere group. The CEA， CYF and SCC in the drug-eluted microsphere group after surgery were lower than those in the blank microsphere group， and the CEA， CYF and SCC in the two groups after surgery were lower than those before surgery， and there were statistical differences in CEA and CYF 1 month after surgery between the two groups. The PFS and OS in drug-eluted microsphere group were higher than those in blank microsphere group. Conclusion CalliSpheres drug-eluting microspheres could improve the effective rate of tumor treatment and prolong the survival time more effectively than the blank microspheres via arterial chemoembolization， providing reliable clinical practice basis for the treatment of advanced non-small cell lung cancer.

Key words： non-small cell lung cancer; drug-carrying microspheres; arterial chemoembolization

Cite this article

Ruiwen CHENG , Ruobing HAO , Ping LI , Kun ZHANG , Liping DENG , Yaheng CAO , Lin SU , Hongrong. SHEN . Clinical efficacy of CalliSpheres drug⁃loaded microspheres versus blank microspheres in the treatment of advanced non⁃small cell lung cancer by transarterial chemoembolization[J]. The Journal of Practical Medicine, 2024 , 40(1) : 32 -37 . DOI: 10.3969/j.issn.1006-5725.2024.01.006

References

1 WOLF J， GARON E B， GROEN H J M，et al. Patient-reported outcomes in capmatinib-treated patients with METex14-mutated advanced NSCLC： Results from the GEOMETRY mono-1 study［J］. Eur J Cancer， 2023， 183： 98-108.
2 SAAD M I， ROSE-JOHN S， JENKINS B J. ADAM17： Anemerging therapeutic target for lung cancer［J］. Cancers （Basel）， 2019，11（9 ）：1218.
3 武阳，陆翰杰，水会锋，等. 既往免疫经治的晚期非小细胞肺癌患者接受安罗替尼联合PD-1单抗的疗效及安全性［J］. 实用医学杂志， 2023， 39（5）： 572-578
4 FELICIANO J L， MCLOONE D， XU Y X， et al. Impact of the treatment crossover design on comparative efficacy in EMPOWER-Lung 1： Cemiplimab monotherapy as first-line treatment of advanced non-small cell lung cancer［J］. Front Oncol， 2022， 12： 1081729.
5 李思玲，商凯，黄鸿翔，等.放疗联合免疫治疗在非小细胞肺癌中的研究进展 ［J］. 实用医学杂志， 2022， 38 （23）： 3017-3022.
6 MOUNTZIOS G， PLANCHARD D， METRO G， et al. Molecular Epidemiology and Treatment Patterns of Patients With EGFR Exon 20-Mutant NSCLC in the Precision Oncology Era： The European EXOTIC Registry［J］. JTO Clin Res Rep， 2023， 4： 100433.
7 LI X B， YIN M P， XIE P F，et al. Bronchial Artery Chemoembolization for Hemoptysis in Advanced Primary Lung Cancer［J］. Clin Lung Cancer， 2022， 23： e203-e209.
8 JIN S Q， ZHAO H Y， BIN B， et al. Transcatheter arterial chemoembolization improves clinical efficacy and life quality of patients with lung cancer and reduces adverse reactions［J］. Am J Transl Res， 2021， 13： 10396-10403.
9 BOAS F E， KEMENY N E， SOFOCLEOUS C T，et al. Bronchial or Pulmonary Artery Chemoembolization for Unresectable and Unablatable Lung Metastases： A Phase I Clinical Trial［J］. Radiology， 2021， 301（2）： 474-484.
10 LI X B， YIN M P， XIE P F， et al. Self-Expandable Metallic Stent Implantation Combined With Bronchial Artery Infusion Chemoembolization in the Treatment of Lung Cancer With Complete Atelectasis［J］. Front Oncol， 2021， 11： 733510.
11 CHEN C， WANG W， YU Z， et al. Combination of computed tomography-guided iodine-125 brachytherapy and bronchial arterial chemoembolization for locally advanced stage Ⅲ non-small cell lung cancer after failure of concurrent chemoradiotherapy［J］. Lung Cancer， 2020， 146： 290-296.
12 BIE Z X， LI Y M， LI B，et al.The efficacy of drug-eluting beads bronchial arterial chemoembolization loaded with gemcitabine for treatment of non-small cell lung cancer［J］. Thorac Cancer，2019，10：1770-1778.
13 王革芳. 经导管动脉灌注化疗药物应用原则——中国肿瘤介入专家共识［J］. 介入放射学杂志，2017，26（11）：963-970.
14 LEE J S， CHOI H J， KIM B K， et al.The Modified Response Evaluation Criteria in Solid Tumors （RECIST） Yield a More Accurate Prognoses Than the RECIST 1.1 in Hepatocellular Carcinoma Treated with Transarterial Radioembolization［J］. Gut Liver， 2020， 14（6）：765-774.
15 郭立文，郑家平，郝伟远，等. 载药微球支气管动脉栓塞化疗治疗晚期非小细胞肺癌10例［J］. 介入放射学杂志，2021，30（1）： 24-28.：
16 ZHU J， ZHANG H P， JIANG S， et al.Neoadjuvant chemotherapy by bronchial arterial infusion in patients with unresectable stage Ⅲ squamous cell lung cancer［J］. Ther Adv Respir Dis， 2017， 11： 301-309.
17 JIN S Q， ZHAO H Y， BAI B， et al. Transcatheter arterial chemoembolization improves clinical efficacy and life quality ofpatients with lung cancer and reduces adverse reactions［J］. Am Transl Res，2021，13（9 ）：10396-10403.
18 BI Y H， REN K W， REN J Z， et al. Oxaliplatin Eluting CalliSpheres Microspheres for the Treatment of Unresectable or Recurrent Hepatocellular Carcinoma［J］. Front Pharmacol， 2022， 13： 923585.
19 WU B L， ZHOU J L， GONG H， et al. CalliSpheres drug-eluting beads versus lipiodol transarterial chemoembolization in the treatment of hepatocellular carcinoma： a short-term efficacy and safety study［J］. World J Surg Oncol， 2018， 16（1）： 69.
20 MA X， ZHENG D， ZHANG J，et al. Clinical outcomes of vinorelbine loading CalliSpheres beads in the treatment of previously treated advanced lung cancer with progressive refractory obstructive atelectasis［J］. Front Bioeng Biotechnol， 2022， 10： 1088274.
21 LIU X， LIN H， WANG Q， et al. Drug-eluting beads bronchial arterial chemoembolization plus intercostals arterial infusion chemotherapy is effective and well-tolerated in treating non-small cell lung cancer patients with refractory malignant pleural effusion ［J］. Thorac Dis，2021，13（4）：2339-2350.
22 XU S， BIE Z X， LI Y M， et al. Drug-Eluting Bead Bronchial Arterial Chemoembolization With and Without Microwave Ablation for the Treatment of Advanced and Standard Treatment-Refractory/Ineligible Non-Small Cell Lung Cancer： A Comparative Study［J］. Front Oncol， 2022，12：851830.
23 LIU J， ZHANG W， REN J， et al. Efficacy and Safety of Drug-Eluting Bead Bronchial Arterial Chemoembolization Plus Anlotinib in Patients With Advanced Non-small-Cell Lung Cancer ［J］. Front Cell Dev Biol， 2021，9：768943.
24 BIE Z X， LI Y M， LI B， et al. The efficacy of drug-eluting beads bronchial arterial chemoembolization loaded with gemcitabine for treatment of non-small cell lung cancer［J］. Thorac Cancer， 2019， 10： 1770-1778.
25 BI Y， ZHANG B， REN J， et al.Clinical outcomes of gemcitabine-loaded callispheres drug-eluting beads for patients with advanced and inoperable lung cancer： A case series study［J］. Front Pharmacol， 2022，13：992526.
26 ZHAO Y W， LIU S， QIN H， et al. Efficacy and safety of CalliSpheres drug-eluting beads for bronchial arterial chemoembolization for refractory non-small-cell lung cancer and its impact on quality of life： A multicenter prospective study［J］. Front Oncol，2023，13：1110917.
27 WANG Z， NIU H， LI Z， et al. Superselective arterial embolization with drug-loaded microspheres for the treatment of unresectable breast cancer［J］. Gland Surg， 2019， 8： 740-747.
28 LIU H， LI Y， LI Z， et al. Bevacizumab loaded CalliSpheres? bronchial arterial chemoembolization combined with immunotherapy and targeted therapy for advanced lung adenocarcinoma［J］. Front Pharmacol， 2023， 14： 1170344.
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