The Journal of Practical Medicine >

2023 , Vol. 39 >Issue 24: 3200 - 3204

DOI: https://doi.org/10.3969/j.issn.1006-5725.2023.24.009

Clinical Research

Relationship between non⁃high density lipoprotein cholesterol and leptomeningeal collaterals in patients with acute middle cerebral artery occlusion

  • Yi AN ,
  • Yanfang YUN ,
  • Guixin YANG ,
  • Haiyan CHEN ,
  • Yongming JIANG ,
  • Dongxu HUANG ,
  • Xiaorong MO ,
  • Xiaolan LI ,
  • Baoyin WEI ,
  • Yingjie ZHOU ,
  • Xuebin LI ,
  • Jianmin. HUANG
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  • Department of Neurology，Affiliated Hospital of Youjiang Medical University for Nationalities，Baise 533000，China

Received date: 2023-06-08

  Online published: 2024-01-10

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Abstract

Objective To explore the relationship between non-high density lipoprotein cholesterol （non-HDL-C） level and leptomeningeal collateral circulation in patients with acute middle cerebral artery occlusion. Methods A total of 85 patients with first-onset acute cerebral infarction with middle cerebral artery M1 segment occlusion were enrolled. According to the results of DSA， LMC circulation was assessed by American Society of Interventional and Therapeutic Neuroradiology/Society of Interventional Radiology Collateral Circulation Assessment System. All patients were assigned to better LMC circulation group （score 2 ~ 4， n = 30） and worse LMC circulation group （score 0 ~ 1， n = 55）， and the levels of non-HDL-C were compared between the two groups. Results The levels of LDL-C and non-HDL-C in worse LMC circulation group were significantly higher than those of the better LMC circulation group（P = 0.026，P = 0.010）. non-HDL-C was an independent risk factor for the worse LMC circulation （OR = 3.019，95%CI：1.053 ~ 8.658，P = 0.04）. LMC circulatory score of patients was negatively correlated with the levels of non-HDL-C level （r = -0.228，P = 0.036） . The AUC of non-HDL-C predicted for the worse LMC circulation was 0.638（95%CI：0.521 ~ 0.755，P = 0.036） . Conclusions non-HDL-C in patients with acute cerebral infarction was significantly related to worse LMC circulation， and was a risk factor for worse LMC circulation. It is suggested that the higher expression of non-HDL-C could be used to predict worse LMC circulation as a serological indicator.

Key words： acute middle cerebral artery occlusion; digital subtraction angiography; non-high density lipoprotein cholesterol; leptomeningeal collateral circulation

Cite this article

Yi AN , Yanfang YUN , Guixin YANG , Haiyan CHEN , Yongming JIANG , Dongxu HUANG , Xiaorong MO , Xiaolan LI , Baoyin WEI , Yingjie ZHOU , Xuebin LI , Jianmin. HUANG . Relationship between non⁃high density lipoprotein cholesterol and leptomeningeal collaterals in patients with acute middle cerebral artery occlusion[J]. The Journal of Practical Medicine, 2023 , 39(24) : 3200 -3204 . DOI: 10.3969/j.issn.1006-5725.2023.24.009

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